Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 617 $8.76 $5,405 Sale
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 617 $32.06 $19,778 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 617 $8.76 $5,405 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 5,521 $35.06 $193,539 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 5,521 $35.06 $193,539 Sale
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 4,473 $35.07 $156,859 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 4,473 $10.13 $45,311 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 4,473 $10.13 $45,311 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (Right to Buy) 5,521 $35.06 $193,539 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 1,103 $8.04 $8,868 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 1,103 $8.04 $8,868 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (Right to Buy) 1,103 $8.04 $8,868 Sale
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 1,500 $11.5 $17,250 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 1,500 $11.5 $17,250 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 1,500 $11.5 $17,250 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 8,642 $35.04 $302,816 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 8,642 $35.04 $302,816 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 7,212 $35.04 $252,708 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 8,550 $35.03 $299,507 Sale
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 8,550 $35.03 $299,507 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 17,100 $35.03 $599,013 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 200 $7.6 $1,520 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 200 $7.6 $1,520 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 200 $7.6 $1,520 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 15,946 $10.13 $161,533 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 26,342 $11.5 $302,933 Sale
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 14,096 $11.5 $162,104 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Stock Option (right to buy) 1,850 $8.76 $16,206 Purchase
VENROCK HEALTHCARE CAPITAL PARTNERS III, L.P. 10 percent o.. 10 percent owner
Common Stock 400,000 $34.5 $13,800,000 Purchase
EVNIN ANTHONY B director director
Common Stock 400,000 $34.5 $13,800,000 Sale
REGENTS OF THE UNIVERSITY OF CALIFORNIA 10 percent owner 10 percent owner
Common Stock 25,600 $32.77 $838,912 Sale
REGENTS OF THE UNIVERSITY OF CALIFORNIA 10 percent owner 10 percent owner
Common Stock 12,800 $32.77 $419,456 Sale
REGENTS OF THE UNIVERSITY OF CALIFORNIA 10 percent owner 10 percent owner
Common Stock 1,148,632 $30.38 $34,891,994 Sale
REGENTS OF THE UNIVERSITY OF CALIFORNIA 10 percent owner 10 percent owner
Common Stock 1,074,316 $30.35 $32,600,119 Option
RAYTHATHA JIGAR director, officer: See Remarks director, officer: See Remarks
Common Stock 102,750 $5.51 $566,153 Sale
RAYTHATHA JIGAR director, officer: See Remarks director, officer: See Remarks
Common Stock 102,750 $28.45 $2,923,546 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 65,626 $21.73 $1,426,053 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 65,626 $7.11 $466,273 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 65,626 $7.11 $466,273 Option
SENDEROWICZ ADRIAN officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (Right to Buy) 27,232 $5.51 $150,048 Option
SENDEROWICZ ADRIAN officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 27,232 $5.51 $150,048 Sale
SENDEROWICZ ADRIAN officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 27,232 $30.09 $819,520 Option
TROJER PATRICK officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 37,920 $6.28 $238,138 Option
TROJER PATRICK officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 37,920 $6.28 $238,138 Sale
TROJER PATRICK officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 46,142 $28.46 $1,313,063 Option
RAYTHATHA JIGAR director, officer: See Remarks director, officer: See Remarks
Stock Option (Right to Buy) 102,750 $5.51 $566,153 Sale
AUDIA JAMES E director director
Common Stock 22,500 $18.42 $414,338 Option
TROJER PATRICK officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,150 $15.01 $17,256 Sale
TROJER PATRICK officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,150 $15.01 $17,256 Option
TROJER PATRICK officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 619 N/A N/A