Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 16,062 $8.62 $138,422 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 12,741 $9.77 $124,480 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 12,741 $9.77 $124,480 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 12,741 $49.53 $631,062 Sale
GOLDSMITH MARK A director director
Common Stock 11,463 $45.06 $516,546 Option
GOLDSMITH MARK A director director
Common Stock 11,463 $6.88 $78,900 Option
GOLDSMITH MARK A director director
Stock Option (right to buy) 11,463 $6.88 $78,900 Sale
AUDIA JAMES E director director
Common Stock 7,500 $45.15 $338,603 Sale
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 12,566 $40.1 $503,897 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 12,566 $10.13 $127,294 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Stock Option (right to buy) 2,467 $8.76 $21,611 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 10,099 $11.5 $116,139 Option
TROJER PATRICK officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 10,000 $6.61 $66,100 Option
TROJER PATRICK officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 10,000 $6.61 $66,100 Sale
TROJER PATRICK officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 10,000 $45.16 $451,550 Option
GOLDSMITH MARK A director director
Common Stock 3,145 $6.88 $21,647 Option
GOLDSMITH MARK A director director
Stock Option (right to buy) 3,145 $6.88 $21,647 Sale
GOLDSMITH MARK A director director
Common Stock 3,145 $40.01 $125,825 Sale
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 4,744 $11.5 $54,556 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 4,744 $11.5 $54,556 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 4,744 $11.5 $54,556 Option
GOLDSMITH MARK A director director
Common Stock 400 $1.55 $620 Sale
GOLDSMITH MARK A director director
Common Stock 400 $1.55 $620 Option
GOLDSMITH MARK A director director
Stock Option (Right to Buy) 400 $1.55 $620 Sale
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 400 $11.5 $4,600 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 400 $11.5 $4,600 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 400 $11.5 $4,600 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 789 $11.5 $9,074 Sale
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 789 $11.5 $9,074 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 789 $11.5 $9,074 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 2,300 $35.19 $80,939 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 2,300 $35.19 $80,939 Sale
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 2,300 $35.19 $80,939 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 760 $6.61 $5,024 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 760 $6.61 $5,024 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 760 $6.61 $5,024 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 2,998 $11.5 $34,477 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Stock Option (Right to Buy) 2,998 $11.5 $34,477 Sale
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 2,998 $33.69 $101,000 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 1,225 $8.76 $10,731 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 1,225 $8.76 $10,731 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 1,225 $8.76 $10,731 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 700 $21.89 $15,322 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Stock Option (right to buy) 635 $8.76 $5,563 Sale
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 635 $8.76 $5,563 Option
VALENTINE KAREN officer: See Remarks officer: See Remarks
Common Stock 635 $8.76 $5,563 Sale
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 111 $8.76 $972 Option
REEVE EMMA officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 700 $21.89 $15,322 Purchase
COLUMN GROUP L P 10 percent owner 10 percent owner
Common Stock 5,539 $23.15 $128,228 Purchase
COLUMN GROUP L P 10 percent owner 10 percent owner
Common Stock 36,135 $22.38 $808,701