Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Pre-funded Warrants to Purchase Common Stock 2,213,816 $0 $2,214 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Pre-funded Warrants to Purchase Common Stock 2,100,244 $0 $2,100 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Pre-funded Warrants to Purchase Common Stock 440,489 $0 $440 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 1,031,385 $2.37 $2,444,382 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Pre-funded Warrants to Purchase Common Stock 3,173,135 $0 $3,173 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 821,121 $2.37 $1,946,057 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Pre-funded Warrants to Purchase Common Stock 2,526,238 $0 $2,526 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Pre-funded Warrants to Purchase Common Stock 232,068 $0 $232 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 75,431 $2.37 $178,771 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 1,055,445 $2.31 $2,438,078 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 837,146 $2.31 $1,933,807 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 86,341 $2.31 $199,448 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Pre-funded Warrants to Purchase Common Stock 2,028,645 $0 $2,029 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Warrants to Purchase Common Stock 2,446,209 $3 $7,338,627 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Warrants to Purchase Common Stock 252,291 $3 $756,873 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Pre-funded Warrants to Purchase Common Stock 1,609,063 $0 $1,609 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Pre-funded Warrants to Purchase Common Stock 165,950 $0 $166 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Warrants to Purchase Common Stock 3,084,090 $3 $9,252,270 Purchase
PERRIN STEVEN director, officer: President director, officer: President
Common Stock 1,000 $2.6 $2,597 Purchase
GROS DAVID-ALEXANDRE C director, officer: Chief Executive .. director, officer: Chief Execut..
Common Stock 2,000 $4.48 $8,960 Purchase
GROS DAVID-ALEXANDRE C
Common Stock 4,000 $6.21 $24,840 Purchase
LITTLE PAUL SEAN
Common Stock 10,000 $8.87 $88,700 Purchase
GROS DAVID-ALEXANDRE C
Common Stock 3,000 $8.01 $24,030 Sale
ORBIMED ISRAEL GP LTD.
Common Stock 103,200 $21.6 $2,229,120 Purchase
LOGOS GLOBAL MANAGEMENT LP
Common Stock 79,098 $25.41 $2,009,564 Sale
LOGOS GLOBAL MANAGEMENT LP
Common Stock 12,969 $26.45 $343,030 Sale
CHIMOVITS EREZ
Warrants to Purchase Common Stock 646,204 $0.2 $129,241 Sale
ORBIMED ISRAEL GP LTD.
Warrants to Purchase Common Stock 646,204 $0.2 $129,241 Sale
FLESHER GREGORY J.
Common Stock 2,937 $1.91 $5,613 Sale
KUWAHARA JON
Common Stock 1,058 $1.91 $2,022 Sale
TURKEL CATHERINE C.
Common Stock 1,914 $1.91 $3,658 Sale
FLESHER GREGORY J.
Common Stock 11,701 $1.96 $22,957 Sale
KUWAHARA JON
Common Stock 4,218 $1.96 $8,276 Sale
TURKEL CATHERINE C.
Common Stock 7,623 $1.96 $14,956 Purchase
CHIMOVITS EREZ
Warrants to Purchase Common Stock 646,204 $3.1 $2,003,232 Purchase
ORBIMED ISRAEL GP LTD.
Common Stock 646,204 $3.1 $2,003,232 Purchase
ORBIMED ISRAEL GP LTD.
Warrants to Purchase Common Stock 646,204 $3.1 $2,003,232 Purchase
CHIMOVITS EREZ
Common Stock 646,204 $3.1 $2,003,232 Sale
LIFESCI INDEX PARTNERS LLC
Common Stock, par value $0.01 per share 200 $2.7 $540 Purchase
TURKEL CATHERINE C.
Common Stock 16,632 $5.02 $83,476 Purchase
TURKEL CATHERINE C.
Common Stock 17,048 $4.56 $77,671 Purchase
TURKEL CATHERINE C.
Common Stock 805 $3.97 $3,193 
