Purchase
GALL MATTHEW officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 5,000 $7.73 $38,635 Purchase
RA CAPITAL MANAGEMENT, L.P. other: Former 10% Owner other: Former 10% Owner
Pre- Funded Warrants (Right to Buy) 5,714,285 $0 $5,714 Purchase
GALL MATTHEW officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 5,000 $8.37 $41,850 Sale
BOXER CAPITAL, LLC
Common Stock 34,846 $14.19 $494,465 Sale
BOXER CAPITAL, LLC
Common Stock 95,516 $15.63 $1,492,915 Sale
BOXER CAPITAL, LLC
Common Stock 219,638 $16.87 $3,705,293 Option
CALL MATTHEW officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 40,226 $2.95 $118,667 Option
CALL MATTHEW officer: Chief Operating Officer officer: Chief Operating Officer
Stock Option (right to buy) 40,226 $2.95 $118,667 Option
HALLAL DAVID director director
Stock Option (Right to Buy) 10,577 $4.23 $44,741 Option
HALLAL DAVID director director
Stock Option (Right to Buy) 11,899 $2.95 $35,102 Option
HALLAL DAVID director director
Common Stock 1,171 $4.23 $4,953 Option
HALLAL DAVID director director
Stock Option (Right to Buy) 1,171 $4.23 $4,953 Option
HALLAL DAVID director director
Stock Option (Right to Buy) 5,968 $4.23 $25,245 Sale
HALLAL DAVID director director
Common Stock 1,171 $19.51 $22,846 Sale
HALLAL DAVID director director
Common Stock 10,577 $19.86 $210,059 Option
HALLAL DAVID director director
Common Stock 10,577 $4.23 $44,741 Option
HALLAL DAVID director director
Common Stock 11,899 $2.95 $35,102 Option
HALLAL DAVID director director
Common Stock 5,968 $4.23 $25,245 Sale
DAVIS AARON I. director director
Common Stock 891 $17.53 $15,621 Sale
DAVIS AARON I. director director
Common Stock 337,109 $18.25 $6,151,902 Sale
DAVIS AARON I. director director
Common Stock 4,850 $24.77 $120,110 Sale
DAVIS AARON I. director director
Common Stock 95,150 $25.18 $2,395,877 Sale
DAVIS AARON I. director director
Common Stock 200,000 $23.47 $4,693,200 Sale
DAVIS AARON I. director director
Common Stock 25,000 $22.91 $572,725 Sale
DAVIS AARON I. director director
Common Stock 92,700 $27.53 $2,552,309 Sale
DAVIS AARON I. director director
Common Stock 7,300 $26.91 $196,407 Sale
DAVIS AARON I. director director
Common Stock 115,000 $27.02 $3,106,725 Sale
DAVIS AARON I. director director
Common Stock 10,000 $28.22 $282,150 Sale
DAVIS AARON I. director director
Common Stock 150,000 $27.4 $4,110,300 Option
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Stock Option (Right to Buy) 11,500 $4.23 $48,645 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 33 $32.64 $1,077 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 11,467 $31.87 $365,453 Option
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 11,500 $4.23 $48,645 Purchase
DAVIS AARON I. director director
Common Stock 20,000 $32.85 $656,980 Purchase
DAVIS AARON I. director director
Common Stock 5,000 $33.43 $167,140 Purchase
DAVIS AARON I. director director
Common Stock 3,700 $33.09 $122,433 Purchase
DAVIS AARON I. director director
Common Stock 21,300 $31.88 $678,938 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 1,548 $36.51 $56,517 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 1,159 $35.22 $40,820 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 9,908 $34.11 $337,962 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 5,822 $33.44 $194,688 Sale
BOXER CAPITAL, LLC 10 percent owner 10 percent owner
Common Stock 575,201 $35.25 $20,275,835 Option
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (Right to Buy) 3,500 $4.3 $15,050 Sale
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,500 $36.01 $126,035 Option
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,500 $4.3 $15,050 Option
MCGRATH YVONNE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 10,000 $4.24 $42,400 Sale
MCGRATH YVONNE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 10,000 $36.76 $367,570 Option
MCGRATH YVONNE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 10,000 $4.24 $42,400 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 544 $35.32 $19,214 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 13,956 $34.3 $478,691