Option
WALLACE OWEN B. officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 2,232 $7.84 $17,499 Sale
GOULD ROBERT J director, officer: See Remarks director, officer: See Remarks
Common Stock 1,919 $20.01 $38,392 Option
CADAVID DIEGO officer: SVP Clinical Development officer: SVP Clinical Development
Common Stock 600 $4.83 $2,898 Sale
CADAVID DIEGO officer: SVP Clinical Development officer: SVP Clinical Development
Common Stock 600 $4.83 $2,898 Option
CADAVID DIEGO officer: SVP Clinical Development officer: SVP Clinical Development
Stock Option (right to buy) 600 $4.83 $2,898 Option
WALLACE OWEN B. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 448 $7.84 $3,512 Sale
WALLACE OWEN B. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 448 $7.84 $3,512 Option
WALLACE OWEN B. officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 448 $7.84 $3,512 Sale
GOULD ROBERT J director, officer: See Remarks director, officer: See Remarks
Common Stock 2,500 $20 $50,000 Option
WALLACE OWEN B. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 412 $7.84 $3,230 Sale
WALLACE OWEN B. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 412 $7.84 $3,230 Option
WALLACE OWEN B. officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 412 $7.84 $3,230 Option
CADAVID DIEGO officer: SVP Clinical Development officer: SVP Clinical Development
Common Stock 1,860 $4.83 $8,984 Sale
CADAVID DIEGO officer: SVP Clinical Development officer: SVP Clinical Development
Common Stock 1,860 $4.83 $8,984 Option
CADAVID DIEGO officer: SVP Clinical Development officer: SVP Clinical Development
Stock Option (right to buy) 1,860 $4.83 $8,984 Sale
THOMSON PETER G. officer: VP Finance & Accounting officer: VP Finance & Accounting
Common Stock 7,500 $16 $120,000 Sale
CADAVID DIEGO officer: SVP Clinical Development officer: SVP Clinical Development
Common Stock 2,143 $17.69 $37,912 Sale
THOMSON PETER G. officer: VP Finance & Accounting officer: VP Finance & Accounting
Common Stock 5,000 $6.2 $31,020 Option
WALLACE OWEN B. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 6,088 N/A N/A Sale
GOULD ROBERT J director, officer: See Remarks director, officer: See Remarks
Common Stock 2,500 N/A N/A Option
WALLACE OWEN B. officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 6,088 N/A N/A Sale
WALLACE OWEN B. officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 6,088 N/A N/A Sale
CADAVID DIEGO officer: SVP Clinical Development officer: SVP Clinical Development
Common Stock 2,143 N/A N/A Sale
THOMSON PETER G. officer: VP Finance & Accounting officer: VP Finance & Accounting
Common Stock 5,000 N/A N/A Purchase
CASDIN CAPITAL, LLC 10 percent owner 10 percent owner
Common Stock 140,000 $15 $2,100,000 Purchase
SANOFI 10 percent owner 10 percent owner
Common Stock (par value $0.001) 93,750 $16 $1,500,000 Purchase
THIRD ROCK VENTURES III, L.P. 10 percent owner 10 percent owner
Common Stock 81,250 $16 $1,300,000 Purchase
THIRD ROCK VENTURES IV, L.P. 10 percent owner 10 percent owner
Common Stock 81,250 $16 $1,300,000 Purchase
6 DIMENSIONS CAPITAL, L.P. 10 percent owner 10 percent owner
Common Stock 118,750 $16 $1,900,000 Purchase
LEVIN MARK J director, 10 percent owner director, 10 percent owner
Common Stock 81,250 N/A N/A