Purchase
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Warrants 2,764,227 N/A N/A Purchase
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Warrants 3,039,514 N/A N/A Purchase
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 3,039,514 $1.52 $4,620,061 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 17,250 $1.77 $30,446 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 12,532 N/A N/A Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 15,000 N/A N/A Sale
KIRBY JOHN J. officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 911 $1.78 $1,622 Sale
FLETCHER ROBERT C. officer: Sr. VP, Bus. Dev. & Strategy officer: Sr. VP, Bus. Dev. & St..
Common Stock 1,615 $1.78 $2,875 Sale
LIM BRYANT DAVID officer: SVP and General Counsel officer: SVP and General Counsel
Common Stock 1,603 $1.78 $2,853 Sale
YINGLING JONATHAN MICHAEL officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,742 $1.78 $3,101 Sale
MILANO VINCENT director, officer: President & CEO director, officer: President & ..
Common Stock 3,006 $1.78 $5,351 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 9,000 $2.44 $21,960 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 10,000 $2.45 $24,500 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 100,000 $2.5 $249,600 Purchase
MILANO VINCENT director, officer: President & CEO director, officer: President & ..
Common Stock 15,000 $2.93 $43,920 Purchase
LIM BRYANT DAVID officer: SVP and General Counsel officer: SVP and General Counsel
Common Stock 4,000 $3.05 $12,200 Purchase
HOROBIN JOANNA officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 300 $3.45 $1,035 Purchase
SCHAFER CAROL director director
Common Stock 5,000 $3.33 $16,670 Purchase
GOLDBERG MARK ALAN director director
Common Stock 10,000 $3.19 $31,900 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 15,000 $6.36 $95,325 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 8,107 $5.89 $47,758 Purchase
MILANO VINCENT director, officer: President & CEO director, officer: President & ..
Common Stock 10,000 $5.51 $55,100 Purchase
GERAGHTY JAMES A director director
Common Stock 10,000 $5.58 $55,800 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 91,893 $5.55 $510,098 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 492,567 $0.86 $422,622 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 556,000 $0.88 $489,280 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 1,725,000 $0.85 $1,469,700 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 874,505 $0.99 $862,262 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 735,771 $1.01 $743,864 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 250,500 $1.05 $264,027 Option
BAKER BROS. ADVISORS LP 10 percent owner 10 percent owner
Common Stock Warrant (right to buy) 2,250,846 $0.47 $1,057,898 Option
BAKER BROS. ADVISORS LP 10 percent owner 10 percent owner
Common Stock 20,316,327 $0.47 $9,548,674 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 200,000 $2.4 $480,000 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 33,830 $1.91 $64,514 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 166,170 $2.01 $333,171 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 500,000 $1.92 $960,000 Purchase
BAKER BROS. ADVISORS LP 10 percent owner 10 percent owner
Common Stock 8,000,000 $1.5 $12,000,000 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 41,578 $2.26 $93,925 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 890,593 $2.29 $2,037,677 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 437,829 $2.29 $1,002,191 Purchase
BAKER JULIAN 10 percent owner 10 percent owner
Common Stock 3,250,000 $2 $6,500,000 Purchase
GOWEN MAXINE director director
Common Stock 4,102 $2.56 $10,501 Purchase
ZEIN YOUSSEF EL 10 percent owner 10 percent owner
Common Stock 4,228 $2.56 $10,824 Purchase
GERAGHTY JAMES A director director
Common Stock 10,000 $1.34 $13,400 Purchase
CASEY MARK J officer: Senior VP & General Counsel officer: Senior VP & General Co..
Common Stock 34,450 $1.44 $49,608 Purchase
MILANO VINCENT director, officer: President & CEO director, officer: President & ..
Common Stock 40,000 $1.97 $78,800 Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 77,586 N/A N/A Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 100,000 N/A N/A Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 676,535 N/A N/A Sale
PILLAR INVEST CORP 10 percent owner 10 percent owner
Common Stock 25,591 N/A N/A