Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 25,000 $0.93 $23,250 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 25,000 $0.93 $23,250 Sale
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 25,000 $22.84 $570,975 Purchase
LOBERG MICHAEL D director director
Common Stock 5,821 $19.62 $114,214 Purchase
LOBERG MICHAEL D director director
Common Stock 6,172 $20.97 $129,402 Purchase
LOBERG MICHAEL D director director
Common Stock 507 $19.99 $10,137 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 10,000 $0.93 $9,300 Sale
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,735 $20.34 $55,633 Sale
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 7,265 $19.57 $142,198 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 10,000 $0.93 $9,300 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 10,000 $0.93 $9,300 Sale
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 10,000 $19.04 $190,390 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 10,000 $0.93 $9,300 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 5,000 $0.93 $4,650 Sale
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 5,000 $19.06 $95,320 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 5,000 $0.93 $4,650 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 6,300 $0.93 $5,859 Sale
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 6,300 $20.71 $130,454 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 6,300 $0.93 $5,859 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 8,700 $0.93 $8,091 Sale
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 8,700 $22.82 $198,543 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 8,700 $0.93 $8,091 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 10,000 $0.93 $9,300 Sale
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 10,000 $22.54 $225,350 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 10,000 $0.93 $9,300 Sale
TAHIR MISBAH officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 950 $17.1 $16,248 Sale
SCHWARZER FRED director, officer: CEO and President director, officer: CEO and Pres..
Common Stock 1,362 $17.1 $23,294 Sale
GAUTHIER GEORGE officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 1,340 $17.1 $22,917 Sale
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 939 $17.1 $16,059 Sale
TAKIMOTO CHRIS H officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 938 $17.1 $16,044 Sale
DECKER LISA LYNN officer: Chief Business Officer officer: Chief Business Officer
Common Stock 1,362 $17.1 $23,293 Purchase
TOPSOE JAKOB HALDOR director, 10 percent owner director, 10 percent owner
Common Stock 1,481 $16 $23,696 Purchase
TOPSOE CHRISTINA TENG director, 10 percent owner director, 10 percent owner
Common Stock 4,510 $14.99 $67,591 Purchase
TOPSOE JAKOB HALDOR director, 10 percent owner director, 10 percent owner
Common Stock 7,850 $14.86 $116,682 Purchase
TOPSOE CHRISTINA TENG director, 10 percent owner director, 10 percent owner
Common Stock 2,290 $14.08 $32,248 Purchase
TOPSOE JAKOB HALDOR director, 10 percent owner director, 10 percent owner
Common Stock 8,254 $14.17 $116,992 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 2,500 $0.93 $2,325 Sale
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,500 $25 $62,500 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,500 $0.93 $2,325 Purchase
TOPSOE HOLDING A/S 10 percent owner 10 percent owner
Non-Voting Common Stock 1,086,957 $23 $25,000,011 Purchase
TOPSOE CHRISTINA TENG director, 10 percent owner director, 10 percent owner
Non-Voting Common Stock 1,086,957 $23 $25,000,011 Purchase
TOPSOE JAKOB HALDOR director, 10 percent owner director, 10 percent owner
Non-Voting Common Stock 1,086,957 $23 $25,000,011 Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Non-Voting Common Stock 2,592,497 $23 $59,627,431 Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Non-Voting Common Stock 233,590 $23 $5,372,570 Purchase
REDMILE GROUP, LLC director, 10 percent owner director, 10 percent owner
Non-Voting Common Stock 2,608,695 $23 $59,999,985 Purchase
BEHRENS M KATHLEEN director director
Common Stock 8,695 $23 $199,985 Purchase
BEHRENS M KATHLEEN director director
Common Stock 8,696 $23 $200,008 Purchase
BEHRENS M KATHLEEN director director
Common Stock 43,478 $23 $999,994 Purchase
LOBERG MICHAEL D director director
Common Stock 21,739 $23 $499,997 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 7,500 $0.93 $6,975