Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,500 $0.93 $2,325 Sale
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 1,226 N/A N/A Sale
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,619 $96 $155,424 Option
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (right to buy) 1,900 $1.39 $2,641 Option
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 1,900 $1.39 $2,641 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 2,500 $0.93 $2,325 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,500 $0.93 $2,325 Option
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 22,420 $18.07 $405,085 Option
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Non-Qualified Stock Options (right to buy) 11,210 $28.14 $315,393 Sale
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 1,102 $79.25 $87,334 Sale
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,503 $79.33 $119,233 Option
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 1,900 $1.39 $2,641 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 2,500 $0.93 $2,325 Option
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (right to buy) 1,900 N/A N/A Sale
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 883 $88.07 $77,766 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,500 N/A N/A Option
TAHIR MISBAH officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 2,750 $1.39 $3,822 Option
TAHIR MISBAH officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 2,750 $1.39 $3,822 Sale
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,618 N/A N/A Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,500 $0.93 $2,325 Option
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 2,500 $0.93 $2,325 Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Pre-funded Warrants 666,666 N/A N/A Purchase
REDMILE GROUP, LLC director, 10 percent owner director, 10 percent owner
Pre-Funded Warrants to Purchase Common Stock 667,666 $0.01 $6,677 Purchase
TOPSOE CHRISTINA TENG director, 10 percent owner director, 10 percent owner
Common Stock 111,111 $90 $9,999,990 Purchase
HALDOR TOPSOE HOLDING A/S 10 percent owner 10 percent owner
Common Stock 111,111 N/A N/A Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Pre-funded Warrants 666,666 N/A N/A Purchase
BEHRENS M KATHLEEN director director
Common Stock 33,333 $45 $1,499,985 Purchase
TOPSOE JAKOB HALDOR director, 10 percent owner director, 10 percent owner
Common Stock 111,111 N/A N/A Sale
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 1,219 $91 $110,929 Option
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (right to buy) 1,900 N/A N/A Option
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 1,900 N/A N/A Sale
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 608 N/A N/A Option
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 950 N/A N/A Option
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (right to buy) 950 $1.39 $1,321 Sale
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 605 N/A N/A Option
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (right to buy) 950 N/A N/A Option
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 950 N/A N/A Sale
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 1,830 N/A N/A Option
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (right to buy) 2,850 N/A N/A Sale
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,000 N/A N/A Option
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 2,850 N/A N/A Sale
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 609 $77.91 $47,447 Option
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 950 $1.39 $1,321 Option
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (right to buy) 950 $1.39 $1,321 Sale
KEYT BRUCE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,000 $60 $60,000 Purchase
BEHRENS M KATHLEEN director director
Common Stock 30,000 $60.74 $1,822,170 Purchase
REDMILE GROUP, LLC director, 10 percent owner director, 10 percent owner
Common Stock 23,260 $52.41 $1,219,010 Sale
CHEN DANIEL SHINYU officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 602 $50.2 $30,220 Purchase
REDMILE GROUP, LLC director, 10 percent owner director, 10 percent owner
Common Stock 47,113 $49.91 $2,351,504 Purchase
REDMILE GROUP, LLC director, 10 percent owner director, 10 percent owner
Common Stock 74,433 $50.28 $3,742,194