Sale
PERKINS ADELENE Q director director
Common Stock 410,196 $0.07 $28,714 Option
PERKINS ADELENE Q director director
Common Stock 768,133 N/A N/A Option
PERKINS ADELENE Q director director
Restricted Stock Unit 768,133 N/A N/A Option
PELUSO STEPHANE director: Chief Scientific Officer director: Chief Scientific Offi..
Restricted Stock Unit 50,000 N/A N/A Sale
PELUSO STEPHANE director: Chief Scientific Officer director: Chief Scientific Offi..
Common Stock 14,994 $0.66 $9,926 Option
PELUSO STEPHANE officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 50,000 N/A N/A Option
SELBY NORMAN C director director
Common Stock 5,000 $0.92 $4,600 Option
SELBY NORMAN C director director
Stock Option (right to buy) 5,000 $0.92 $4,600 Sale
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 2,260,085 $5.37 $12,134,396 Sale
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 2,260,085 $5.37 $12,134,396 Sale
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 5,848,520 $4.14 $24,207,024 Sale
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 5,848,520 $4.14 $24,207,024 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 175,000 $1.2 $210,000 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 100,000 $1.3 $130,000 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 4,700 $1.35 $6,345 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 1,465,126 $1.36 $1,992,571 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 1,465,126 N/A N/A Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 91,474 $1.35 $123,490 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 91,474 $1.35 $123,490 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 210,250 $1.34 $281,735 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 210,250 $1.34 $281,735 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 604,208 $1.35 $815,681 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 604,208 $1.35 $815,681 Sale
PERKINS ADELENE Q director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 5,000 $2.82 $14,100 Sale
KUTOK JEFFERY officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 6,133 $2 $12,266 Sale
KUTOK JEFFERY officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 8,180 $2.01 $16,417 Sale
KUTOK JEFFERY officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 14,313 $2.01 $28,698 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 425,531 $1.65 $702,126 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 425,531 $1.65 $702,126 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 3,516,560 $1.65 $5,802,324 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 3,516,560 $1.65 $5,802,324 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 3,516,560 $1.65 $5,802,324 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 1,010,000 $2 $2,020,000 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 500,000 $1.9 $950,000 Sale
PERKINS ADELENE Q director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 5,000 $2.78 $13,890 Purchase
BLOCH LAWRENCE E officer: President officer: President
Common Stock 500,000 $1.81 $905,000 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 653,449 $1.28 $839,029 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 946,597 $1.24 $1,169,047 Sale
VENUTI MICHAEL C director director
Common Stock 6,250 $3.48 $21,750 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 4,379 $1.34 $5,868 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 3,553 $1.34 $4,761 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 738,848 $1.34 $987,101 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 22,001 $1.36 $29,811 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 198,264 $1.36 $269,243 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 434,656 $1.28 $556,360 Sale
KANGO SUJAY officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 49,991 $1.27 $63,689 Sale
KANGO SUJAY officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 25,009 $1.3 $32,612 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 52,500 $1.19 $62,475 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Stock, $0.001 par value 148,894 $1.19 $176,439 Sale
PERKINS ADELENE Q director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 5,000 $10.93 $54,650