Option
JACOBS BRUCE N. officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (Right to Buy) 10,000 $2.08 $20,800 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 27,117 $26 $705,042 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 233,362 $26 $6,067,412 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 285,046 $26 $7,411,196 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 26,353 $14.78 $389,576 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 3,223 $14.78 $47,646 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 35,793 $14.78 $529,128 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 10,642 $14.21 $151,233 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 123,043 $14.21 $1,748,564 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 90,372 $14.21 $1,284,276 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 37 $14 $518 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 5,883 $14 $82,356 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 4,180 $14 $58,516 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 55,210 $19.26 $1,063,069 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 40,659 $19.26 $782,889 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 4,131 $19.26 $79,542 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 75,495 $19.6 $1,479,627 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 4,066 $19.6 $79,690 Purchase
BVF PARTNERS L P/IL other: See Remarks and Footnotes other: See Remarks and Footnotes
Common Stock, $0.0001 par value 70,439 $19.6 $1,380,534 Option
GOLLOB JARED officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 10,208 $1.31 $13,372 Option
GOLLOB JARED officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (Right to Buy) 10,208 $1.31 $13,372 Option
GOLLOB JARED officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (Right to Buy) 9,792 $2.08 $20,367 Option
GOLLOB JARED officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 9,792 $2.08 $20,367 Option
JACOBS BRUCE N. officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 20,000 $2.08 $41,600 Option
JACOBS BRUCE N. officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (Right to Buy) 20,000 $2.08 $41,600 Option
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Stock Option (Right to Buy) 20,000 $2.08 $41,600 Option
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 20,000 $2.08 $41,600 Purchase
BVF PARTNERS L P/IL other: See Remarks other: See Remarks
Common Stock, $0.0001 par value 14,323 $40.7 $582,946 Purchase
BVF PARTNERS L P/IL other: See Remarks other: See Remarks
Common Stock, $0.0001 par value 20,085 $40.7 $817,460 Purchase
BVF PARTNERS L P/IL other: See Remarks other: See Remarks
Common Stock, $0.0001 par value 95,901 $38.33 $3,676,077 Purchase
BVF PARTNERS L P/IL other: See Remarks other: See Remarks
Common Stock, $0.0001 par value 272,767 $37.76 $10,300,773 Option
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Stock Option (Right to Buy) 10,000 $2.08 $20,800 Option
JACOBS BRUCE N. officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (Right to Buy) 10,000 $2.08 $20,800 Option
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 10,000 $2.08 $20,800 Option
JACOBS BRUCE N. officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 10,000 $2.08 $20,800 Sale
JACOBS BRUCE N. officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 15,000 $52.2 $783,060 Option
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 8,612 $2.08 $17,913 Option
JACOBS BRUCE N. officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (Right to Buy) 15,000 $2.08 $31,200 Option
JACOBS BRUCE N. officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 15,000 $2.08 $31,200 Sale
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 8,612 $52.64 $453,353 Option
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Stock Option (Right to Buy) 48,000 $2.08 $99,840 Option
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 16,923 $2.08 $35,200 Sale
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 16,923 $54.38 $920,340 Option
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 22,465 $2.08 $46,727 Sale
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 22,465 $53.8 $1,208,595 Option
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Stock Option (Right to Buy) 8,000 $2.08 $16,640 Option
MAINOLFI NELLO director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 8,000 $2.08 $16,640 Option
JACOBS BRUCE N. officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 10,000 $2.08 $20,800 Option
JACOBS BRUCE N. officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (Right to Buy) 10,000 $2.08 $20,800 Sale
JACOBS BRUCE N. officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 10,000 $54.23 $542,320