Option
BOXER CAPITAL, LLC 10 percent owner 10 percent owner
Warrant (right to purchase) 425,006 $0 $425 Sale
BRASLYN LTD. 10 percent owner 10 percent owner
Common Stock 275,000 $69 $18,975,000 Option
BRASLYN LTD. 10 percent owner 10 percent owner
Warrant (right to purchase) 275,004 $0 $275 Option
BRASLYN LTD. 10 percent owner 10 percent owner
Common Stock 275,004 $0 $275 Option
BAUM CHARLES M director, officer: President & CEO director, officer: President & ..
Common Stock 103,620 $8.5 $880,770 Sale
BAUM CHARLES M director, officer: President & CEO director, officer: President & ..
Common Stock 51,810 $76.95 $3,986,728 Option
BAUM CHARLES M director, officer: President & CEO director, officer: President & ..
Common Stock 51,810 $8.5 $440,385 Option
BAUM CHARLES M director, officer: President & CEO director, officer: President & ..
Stock Option (Right to Buy) 3,623 $17.3 $62,678 Option
BAUM CHARLES M director, officer: President & CEO director, officer: President & ..
Common Stock 3,623 $17.3 $62,678 Sale
CARTER BRUCE L A director director
Common Stock 3,000 $73.58 $220,728 Option
CARTER BRUCE L A director director
Common Stock 3,000 $6.78 $20,340 Sale
VENBIO SELECT ADVISOR LLC
Common Stock, $0.001 par value per share 686,820 N/A N/A Option
CARTER BRUCE L A director director
Non-Qualified Stock Option (right to buy) 3,000 $6.78 $20,340 Sale
DONADIO JAMIE A officer: Sr. VP, CFO officer: Sr. VP, CFO
Common Stock 7,500 $5.4 $40,500 Option
DONADIO JAMIE A officer: Sr. VP, CFO officer: Sr. VP, CFO
Employee Stock Option (Right to Buy) 7,500 $5.4 $40,500 Option
DONADIO JAMIE A officer: Sr. VP, CFO officer: Sr. VP, CFO
Common Stock 7,500 $5.4 $40,500 Sale
LEMASTERS CHRISTOPHER C. officer: EVP, Chief Business Offi.. officer: EVP, Chief Business Of..
Common Stock 60,000 $71.85 $4,311,120 Option
LEMASTERS CHRISTOPHER C. officer: EVP, Chief Business Offi.. officer: EVP, Chief Business Of..
Common Stock 60,000 $6.45 $387,000 Option
JOHNSON CRAIG A director director
Non-Qualified Stock Option (Right to Buy) 7,000 $15.79 $110,530 Option
JOHNSON CRAIG A director director
Common Stock 17,000 $9.72 $165,240 Sale
JOHNSON CRAIG A director director
Common Stock 17,000 $61.46 $1,044,752 Option
CHEN ISAN officer: EVP, Chief Medical Officer officer: EVP, Chief Medical Off..
Employee Stock Option (Right to Buy) 626 $13.46 $8,423 Option
CHEN ISAN officer: EVP, Chief Medical Officer officer: EVP, Chief Medical Off..
Common Stock 870 $17.3 $15,051 Option
CHEN ISAN officer: EVP, Chief Medical Officer officer: EVP, Chief Medical Off..
Stock Options 244 $24.99 $6,098 Purchase
BOXER CAPITAL, LLC 10 percent owner 10 percent owner
Common Stock 150,000 $62 $9,300,000 Option
REISMAN NEIL 10 percent owner 10 percent owner
Employee Stock Option (right to buy) 10,000 $27 $270,000 Option
REISMAN NEIL 10 percent owner 10 percent owner
Common Stock 25,972 $15.53 $403,215 Sale
BOXER CAPITAL, LLC 10 percent owner 10 percent owner
Common Stock 150,000 $51.3 $7,695,450 Option
BOXER CAPITAL, LLC 10 percent owner 10 percent owner
Warrant (right to purchase) 150,003 $0 $150 Option
BOXER CAPITAL, LLC 10 percent owner 10 percent owner
Common Stock 150,003 $0 $150 Sale
DAVIS AARON I. director, 10 percent owner director, 10 percent owner
Common Stock 10,000 $53.4 $534,000 Option
BOXER CAPITAL, LLC 10 percent owner 10 percent owner
Common Stock 550,012 $0 $550 Option
BOXER CAPITAL, LLC 10 percent owner 10 percent owner
Warrant (right to purchase) 550,012 $0 $550 Sale
BOXER CAPITAL, LLC 10 percent owner 10 percent owner
Common Stock 550,000 $52.38 $28,806,250 Sale
DAVIS AARON I. director, 10 percent owner director, 10 percent owner
Common Stock 40,000 $46.41 $1,856,520 Option
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Employee Stock Option (Right to Buy) 5,169 $17.41 $89,992 Option
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 5,169 $17.41 $89,992 Option
BAUM CHARLES M director, officer: President & CEO director, officer: President & ..
Common Stock 11,486 $17.41 $199,971 Option
BAUM CHARLES M director, officer: President & CEO director, officer: President & ..
Common Stock 22,972 $17.41 $399,943 Option
BAUM CHARLES M director, officer: President & CEO director, officer: President & ..
Common Stock 103,620 $8.5 $880,770 Sale
BAUM CHARLES M director, officer: President & CEO director, officer: President & ..
Common Stock 51,810 $57.71 $2,990,162 Option
BAUM CHARLES M director, officer: President & CEO director, officer: President & ..
Common Stock 51,810 $8.5 $440,385 Option
CHEN ISAN officer: EVP, Chief Medical Officer officer: EVP, Chief Medical Off..
Common Stock 1,867 $19.46 $36,332 Option
CHEN ISAN officer: EVP, Chief Medical Officer officer: EVP, Chief Medical Off..
Employee Stock Option (Right to Buy) 1,867 $19.46 $36,332 Option
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 4,999 $5.5 $27,495 Option
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Employee Stock Option (Right to Buy) 4,999 $5.5 $27,495 Sale
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 4,999 $50.3 $251,450 Option
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Employee Stock Option (Right to Buy) 5,208 $5.4 $28,123 Option
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 5,208 $5.4 $28,123 Sale
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 5,208 $48.95 $254,906