Purchase
BRASLYN LTD. 10 percent owner 10 percent owner
Common Stock 21,085 $5.48 $115,546 Purchase
BRASLYN LTD. 10 percent owner 10 percent owner
Common Stock 16,200 $5.5 $89,100 Purchase
BRASLYN LTD. 10 percent owner 10 percent owner
Common Stock 17,800 $5.5 $97,900 Purchase
BRASLYN LTD. 10 percent owner 10 percent owner
Common Stock 52,311 $5.49 $287,187 Purchase
BRASLYN LTD. 10 percent owner 10 percent owner
Common Stock 49,776 $5.5 $273,768 Purchase
BOXER CAPITAL, LLC 10 percent owner 10 percent owner
Warrant (right to purchase) 2,392,833 $0 $2,393 Purchase
BOXER CAPITAL, LLC 10 percent owner 10 percent owner
Common Stock 286,163 $5.6 $1,602,513 Purchase
BRASLYN LTD. 10 percent owner 10 percent owner
Warrant (right to purchase) 4,865,430 $0 $4,865 Purchase
BRASLYN LTD. 10 percent owner 10 percent owner
Common Stock 581,870 $5.6 $3,258,472 Purchase
BAUM CHARLES M director, officer: President & CEO director, officer: President & ..
Common Stock 20,000 $7.05 $141,080 Sale
BAKER BROS. ADVISORS LP other: Former 10% Owner other: Former 10% Owner
Common Stock 545,058 $9.48 $5,166,605 Sale
BAKER BROS. ADVISORS LP other: Former 10% Owner other: Former 10% Owner
Common Stock 158,100 $9.21 $1,456,417 Sale
BAKER BROS. ADVISORS LP other: Former 10% Owner other: Former 10% Owner
Common Stock 296,200 $9.44 $2,795,536 Purchase
BRASLYN LTD. 10 percent owner 10 percent owner
Common Stock 161,751 $9.49 $1,535,017 Purchase
BRASLYN LTD. 10 percent owner 10 percent owner
Common Stock 215,151 $10.31 $2,217,346 Purchase
BRASLYN LTD. 10 percent owner 10 percent owner
Common Stock 4,500 $17.15 $77,175 Purchase
BRASLYN LTD. 10 percent owner 10 percent owner
Common Stock 61,282 $18.29 $1,120,725 Purchase
BRASLYN LTD. 10 percent owner 10 percent owner
Common Stock 3,400 $19.09 $64,906 Purchase
BRASLYN LTD. 10 percent owner 10 percent owner
Common Stock 300 $19.48 $5,844 Purchase
BRASLYN LTD. 10 percent owner 10 percent owner
Common Stock 20,548 $19.36 $397,809 Purchase
BRASLYN LTD. 10 percent owner 10 percent owner
Common Stock 1,166 $19.34 $22,550 Option
GERGEN MARK J officer: Executive VP, COO officer: Executive VP, COO
Common Stock 15,000 $17.21 $258,165 Sale
GERGEN MARK J officer: Executive VP, COO officer: Executive VP, COO
Common Stock 10,000 $25.92 $259,210 Option
GERGEN MARK J officer: Executive VP, COO officer: Executive VP, COO
Incentive Stock Option (right to buy) 5,000 $8.5 $42,500 Option
GERGEN MARK J officer: Executive VP, COO officer: Executive VP, COO
Non Qualified Stock Option (right to buy) 10,000 $25.92 $259,210 Option
CHEN ISAN officer: EVP, Chief Medical Officer officer: EVP, Chief Medical Off..
Common Stock 2,542 $15.79 $40,138 Option
CHEN ISAN officer: EVP, Chief Medical Officer officer: EVP, Chief Medical Off..
Incentive Stock Option (right to buy) 2,542 $15.79 $40,138 Sale
BOXER CAPITAL, LLC 10 percent owner 10 percent owner
Warrant (right to purchase) 1 $6.74 $7 Purchase
BAKER BROS. ADVISORS LP other: Former 10% Owner other: Former 10% Owner
Common Stock 150,000 $45 $6,750,000 Purchase
BOXER CAPITAL, LLC 10 percent owner 10 percent owner
Common Stock 45,000 $45 $2,025,000 Option
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Employee Stock Option (Right to Buy) 4,750 $17.41 $82,698 Sale
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 4,750 $28.07 $133,337 Option
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 4,750 $17.41 $82,698 Option
CHEN ISAN officer: EVP, Chief Medical Officer officer: EVP, Chief Medical Off..
Employee Stock Option (Right to Buy) 12,666 $15.79 $199,996 Option
CHEN ISAN officer: EVP, Chief Medical Officer officer: EVP, Chief Medical Off..
Common Stock 12,666 $15.79 $199,996 Option
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Employee Stock Option (Right to Buy) 6,000 $8.5 $51,000 Option
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 6,000 $8.5 $51,000 Sale
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 6,000 $25.6 $153,570 Option
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 3,100 $23.03 $71,378 Option
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Employee Stock Option (Right to Buy) 3,100 $23.03 $71,378 Sale
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 3,100 $23.03 $71,378 Option
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Employee Stock Option (Right to Buy) 400 $8.5 $3,400 Sale
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 1,250 $22.29 $27,863 Option
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 400 $8.5 $3,400 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 100,000 $20 $2,000,000 Purchase
BAKER BROS. ADVISORS LP other: Former 10% Owner other: Former 10% Owner
Common Stock 425,000 $20 $8,500,000 Purchase
BOXER CAPITAL, LLC 10 percent owner 10 percent owner
Common Stock 550,000 $20 $11,000,000 Option
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Employee Stock Option (Right to Buy) 2,500 $8.5 $21,250 Option
CHRISTENSEN JAMIE officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 2,500 $8.5 $21,250 Option
BAUM CHARLES M director, officer: President & CEO director, officer: President & ..
Stock Option (Right to Buy) 11,778 $8.49 $99,995