Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Shares, no par value 61,156 $11.68 $714,424 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Shares, no par value 464,235 $11.68 $5,423,193 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Shares, no par value 660,654 $11.68 $7,717,760 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Shares, no par value 5,730 $8.5 $48,705 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Shares, no par value 189,882 $8.5 $1,613,997 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Shares, no par value 224,388 $8.5 $1,907,298 Sale
ZINDA MICHAEL officer: EVP, Chief Science Officer officer: EVP, Chief Science Off..
Common Shares 533 $11.3 $6,023 Option
SEGAL LLOYD MITCHELL director, officer: President and CEO director, officer: President an..
Employee Stock Option (right to buy) 300,000 $15.63 $4,689,000 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Shares, no par value 577,798 $14.1 $8,146,952 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Shares, no par value 7,899 $14.1 $111,376 Purchase
BVF PARTNERS L P/IL 10 percent owner 10 percent owner
Common Shares, no par value 412,264 $14.1 $5,812,922 Option
SEGAL LLOYD MITCHELL officer: President and CEO officer: President and CEO
Employee Stock Option (right to buy) 300,000 $15.63 $4,689,000 Option
ZINDA MICHAEL officer: EVP, Chief Science Officer officer: EVP, Chief Science Off..
Employee Stock Option (right to buy) 115,000 $15.63 $1,797,450 Option
KOEHLER MARIA officer: EVP, Chief Medical Officer officer: EVP, Chief Medical Off..
Employee Stock Option (right to buy) 115,000 $15.63 $1,797,450 Option
FORTE STEVE officer: EVP, Chief Financial Officer officer: EVP, Chief Financial O..
Employee Stock Option (right to buy) 100,000 $15.63 $1,563,000 Option
KOEHLER MARIA officer: EVP, Chief Medical Officer officer: EVP, Chief Medical Off..
Employee Stock Option (right to buy) 48,511 $2.24 $108,859 Option
KOEHLER MARIA officer: EVP, Chief Medical Officer officer: EVP, Chief Medical Off..
Common Shares 48,511 $2.24 $108,859 Option
ZINDA MICHAEL officer: EVP, Chief Science Officer officer: EVP, Chief Science Off..
Employee Stock Option (right to buy) 41,919 $2.04 $85,557 Option
ZINDA MICHAEL officer: EVP, Chief Science Officer officer: EVP, Chief Science Off..
Common Shares 46,041 $1.94 $89,320 Purchase
CIVIK THOMAS director director
Common Shares 7,500 $28.08 $210,600 Sale
ZINDA MICHAEL officer: EVP, Chief Science Officer officer: EVP, Chief Science Off..
Common Shares 20,000 $27.54 $550,700 Sale
ORBIMED ADVISORS LLC director director
Common Stock 887 $33.93 $30,096 Sale
BONITA DAVID P director director
Common Stock 887 $33.93 $30,096 Sale
ORBIMED ADVISORS LLC director director
Common Stock 7,197 $34 $244,698 Sale
BONITA DAVID P director director
Common Stock 7,197 $34 $244,698 Sale
BONITA DAVID P director director
Common Stock 16,424 $34.24 $562,358 Sale
ORBIMED ADVISORS LLC director director
Common Stock 16,424 $34.24 $562,358 Sale
BONITA DAVID P director director
Common Stock 12,968 $33.98 $440,653 Sale
ORBIMED ADVISORS LLC director director
Common Stock 12,968 $33.98 $440,653 Sale
BONITA DAVID P director director
Common Stock 8,472 $33.94 $287,540 Sale
ORBIMED ADVISORS LLC director director
Common Stock 8,472 $33.94 $287,540 Sale
BONITA DAVID P director director
Common Stock 6,697 $33.92 $227,162 Sale
ORBIMED ADVISORS LLC director director
Common Stock 6,697 $33.92 $227,162 Sale
BONITA DAVID P director director
Common Stock 7,093 $33.94 $240,736 Sale
ORBIMED ADVISORS LLC director director
Common Stock 7,093 $33.94 $240,736 Sale
BONITA DAVID P director director
Common Stock 4,283 $34.52 $147,849 Sale
ORBIMED ADVISORS LLC director director
Common Stock 4,283 $34.52 $147,849 Sale
BONITA DAVID P director director
Common Stock 7,082 $34.34 $243,196 Sale
ORBIMED ADVISORS LLC director director
Common Stock 7,082 $34.34 $243,196 Sale
BONITA DAVID P director director
Common Stock 4,039 $34.07 $137,609 Sale
ORBIMED ADVISORS LLC director director
Common Stock 4,039 $34.07 $137,609 Sale
BONITA DAVID P director director
Common Stock 7,094 $34.06 $241,622 Sale
ORBIMED ADVISORS LLC director director
Common Stock 7,094 $34.06 $241,622 Sale
BONITA DAVID P director director
Common Stock 2,930 $33.99 $99,591 Sale
ORBIMED ADVISORS LLC director director
Common Stock 2,930 $33.99 $99,591 Sale
BONITA DAVID P director director
Common Stock 17,398 $34.12 $593,620 Sale
ORBIMED ADVISORS LLC director director
Common Stock 17,398 $34.12 $593,620 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Shares 58,012 N/A N/A Sale
FOLEY TODD director director
Common Shares 25,559 N/A N/A Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Shares 58,012 $33.84 $1,963,126