Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 762,380 $5.25 $4,002,495 Sale
5AM PARTNERS IV, LLC 10 percent owner 10 percent owner
Common Stock 19,017 $4.09 $77,780 Sale
5AM PARTNERS IV, LLC 10 percent owner 10 percent owner
Common Stock 456,413 $4.09 $1,866,729 Sale
5AM PARTNERS IV, LLC 10 percent owner 10 percent owner
Common Stock 87,036 $4.09 $355,977 Option
TUCKER JOHN H director, officer: President and CEO director, officer: President an..
Restricted Stock Units 42,250 N/A N/A Option
TUCKER JOHN H director, officer: President and CEO director, officer: President an..
Common Stock 42,250 N/A N/A Sale
5AM PARTNERS IV, LLC 10 percent owner 10 percent owner
Common Stock 30,173 $4.75 $143,322 Sale
5AM PARTNERS IV, LLC 10 percent owner 10 percent owner
Common Stock 6,793 $4.75 $32,267 Sale
5AM PARTNERS IV, LLC 10 percent owner 10 percent owner
Common Stock 163,034 $4.75 $774,412 Sale
5AM PARTNERS IV, LLC 10 percent owner 10 percent owner
Common Stock 4,016 $5.52 $22,168 Sale
5AM PARTNERS IV, LLC 10 percent owner 10 percent owner
Common Stock 904 $5.52 $4,990 Sale
5AM PARTNERS IV, LLC 10 percent owner 10 percent owner
Common Stock 21,702 $5.52 $119,795 Sale
5AM PARTNERS IV, LLC 10 percent owner 10 percent owner
Common Stock 40,733 $5 $203,665 Sale
5AM PARTNERS IV, LLC 10 percent owner 10 percent owner
Common Stock 9,171 $5 $45,855 Sale
5AM PARTNERS IV, LLC 10 percent owner 10 percent owner
Common Stock 220,096 $5 $1,100,480 Purchase
KHATTAR JACK A. director director
Common Stock 5,000 $3.91 $19,570 Purchase
TUCKER JOHN H director, officer: President and CEO director, officer: President an..
Common Stock 10,000 $3.96 $39,550 Sale
RA CAPITAL MANAGEMENT, L.P. 10 percent owner 10 percent owner
Common Stock 110,588 N/A N/A Sale
RA CAPITAL MANAGEMENT, L.P. 10 percent owner 10 percent owner
Common Stock 39,469 N/A N/A Option
TUCKER JOHN H director, officer: President and CEO director, officer: President an..
Restricted Stock Units 42,250 N/A N/A Option
TUCKER JOHN H director, officer: President and CEO director, officer: President an..
Common Stock 42,250 N/A N/A Purchase
SCHWAB ANDREW J. 10 percent owner 10 percent owner
Common Stock 578,034 N/A N/A Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 1,387,283 N/A N/A Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 1,387,283 $8.65 $11,999,998 Purchase
RA CAPITAL MANAGEMENT, L.P. 10 percent owner 10 percent owner
Common Stock 543,986 N/A N/A Purchase
RA CAPITAL MANAGEMENT, L.P. 10 percent owner 10 percent owner
Common Stock 543,986 $8.2 $4,460,685 Purchase
TUCKER JOHN H director, officer: President and CEO director, officer: President an..
Common Stock 5,000 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC
Common Stock 389,862 N/A N/A Option
SCHAEFFER LEONARD D director director
Stock Option (Right to Buy) 22,631 N/A N/A Option
SCHAEFFER LEONARD D director director
Common Stock 22,631 N/A N/A Purchase
LUNDBECKFOND INVEST A/S 10 percent owner 10 percent owner
Common Stock 654,762 N/A N/A Purchase
AGGER METTE KIRSTINE director director
Common Stock 654,762 N/A N/A Purchase
SUN PHARMACEUTICAL INDUSTRIES LTD 10 percent owner 10 percent owner
Common Stock 357,143 N/A N/A Purchase
5AM PARTNERS IV, LLC 10 percent owner 10 percent owner
Common Stock 654,762 N/A N/A Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 833,333 N/A N/A