Option
SHAKESPEARE WILLIAM officer: See Remarks officer: See Remarks
Common Stock 251,084 $0.32 $80,347 Option
SHAKESPEARE WILLIAM officer: See Remarks officer: See Remarks
Stock Option (right to buy) 251,084 $0.32 $80,347 Purchase
GORDON CARL L director, 10 percent owner: director, 10 percent owner:
Common Stock 328,482 $3.05 $1,001,870 Purchase
GORDON CARL L director, 10 percent owner: director, 10 percent owner:
Common Stock 151,450 $3.05 $461,923 Purchase
ORBIMED ADVISORS LLC director, 10 percent owner: director, 10 percent owner:
Common Stock 328,482 $3.05 $1,001,870 Purchase
ORBIMED ADVISORS LLC director, 10 percent owner: director, 10 percent owner:
Common Stock 151,450 $3.05 $461,923 Purchase
FORESITE CAPITAL MANAGEMENT V, LLC 10 percent owner 10 percent owner
Common Stock 523,450 $2.97 $1,554,647 Purchase
FORESITE CAPITAL MANAGEMENT V, LLC 10 percent owner 10 percent owner
Common Stock 176,550 $2.97 $524,354 Purchase
HAYDEN DONALD J JR director director
Common Stock 9,900 $5 $49,490 Purchase
FORESITE CAPITAL MANAGEMENT V, LLC 10 percent owner 10 percent owner
Common Stock 250,000 $5 $1,250,000 Purchase
FORESITE CAPITAL MANAGEMENT V, LLC 10 percent owner 10 percent owner
Common Stock 250,000 $5 $1,250,000 Purchase
HAYDEN DONALD J JR director director
Common Stock 100 $5 $500 Purchase
DAHMS BRADFORD D. officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 1,502 $6.66 $9,999 Purchase
CLACKSON TIMOTHY P director, officer: President and CEO director, officer: President an..
Common Stock 2,500 $6.8 $16,995 Purchase
GORDON CARL L director, 10 percent owner director, 10 percent owner
Common Stock 192,000 $5.21 $1,000,320 Purchase
ORBIMED ADVISORS LLC director, 10 percent owner director, 10 percent owner
Common Stock 192,000 $5.21 $1,000,320 Purchase
GORDON CARL L director, 10 percent owner director, 10 percent owner
Common Stock 111,896 $9.97 $1,115,603 Purchase
ORBIMED ADVISORS LLC director, 10 percent owner director, 10 percent owner
Common Stock 111,896 $9.97 $1,115,603 Purchase
GORDON CARL L director, 10 percent owner director, 10 percent owner
Common Stock 35,000 $9.95 $348,250 Purchase
ORBIMED ADVISORS LLC director, 10 percent owner director, 10 percent owner
Common Stock 35,000 $9.95 $348,250 Purchase
GORDON CARL L director, 10 percent owner director, 10 percent owner
Common Stock 11,521 $9.97 $114,864 Purchase
ORBIMED ADVISORS LLC director, 10 percent owner director, 10 percent owner
Common Stock 11,521 $9.97 $114,864 Purchase
GORDON CARL L director, 10 percent owner director, 10 percent owner
Common Stock 17,320 $9.43 $163,328 Purchase
ORBIMED ADVISORS LLC director, 10 percent owner director, 10 percent owner
Common Stock 17,320 $9.43 $163,328 Purchase
GORDON CARL L director, 10 percent owner director, 10 percent owner
Common Stock 18,897 $10.06 $190,104 Purchase
ORBIMED ADVISORS LLC director, 10 percent owner director, 10 percent owner
Common Stock 18,897 $10.06 $190,104 Purchase
GORDON CARL L director, 10 percent owner director, 10 percent owner
Common Stock 8,500 $10.24 $87,040 Purchase
ORBIMED ADVISORS LLC director, 10 percent owner director, 10 percent owner
Common Stock 8,500 $10.24 $87,040 Purchase
DAHMS BRADFORD D. officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 1,970 $10.15 $19,999 Purchase
CLACKSON TIMOTHY P director, officer: President and CEO director, officer: President an..
Common Stock 2,600 $9.76 $25,381 Purchase
SHAKESPEARE WILLIAM officer: President of Research and Dev.. officer: President of Research ..
Common Stock 625 $16 $10,000 Purchase
ORBIMED ADVISORS LLC director, 10 percent owner director, 10 percent owner
Common Stock 625,000 $16 $10,000,000 Purchase
ROCK SPRINGS CAPITAL MANAGEMENT LP 10 percent owner 10 percent owner
Common Stock 250,000 $16 $4,000,000 Purchase
GORDON CARL L director, 10 percent owner director, 10 percent owner
Common Stock 625,000 $16 $10,000,000 Purchase
OMEGA FUND VI, L.P. other other
Common Stock 187,500 $16 $3,000,000