| Utility: Method of producing alkaline phosphatase Filling date: 8 Sep 2025 Issue date: 27 Apr 2021 | 6 Jun 2017 | 27 Apr 2021 |
| Utility: LIQUID FORMULATIONS OF ANTI-CD200 ANTIBODIES Filling date: 8 Sep 2025 Issue date: 25 Mar 2021 | 18 Dec 2018 | 25 Mar 2021 |
| Utility: Preparation of factor Xa derivatives Filling date: 8 Sep 2025 Issue date: 23 Mar 2021 | 10 Jan 2020 | 23 Mar 2021 |
| Utility: Antidotes for factor Xa inhibitors and methods of using the same Filling date: 8 Sep 2025 Issue date: 23 Mar 2021 | 17 Jan 2019 | 23 Mar 2021 |
| Utility: METHODS OF SHIFTING AN ISOELECTRIC PROFILE OF A PROTEIN PRODUCT AND USES THEREOF Filling date: 8 Sep 2025 Issue date: 4 Mar 2021 | 11 Jun 2020 | 4 Mar 2021 |
| Utility: Compositions comprising an anti-C5 antibody Filling date: 8 Sep 2025 Issue date: 23 Feb 2021 | 9 Oct 2019 | 23 Feb 2021 |
| Utility: HIGH THROUGHPUT METHOD FOR MEASURING THE PROTEASE ACTIVITY OF COMPLEMENT C3 CONVERTASE Filling date: 8 Sep 2025 Issue date: 28 Jan 2021 | 21 Mar 2019 | 28 Jan 2021 |
| Utility: Methods for treating hypophosphatasia in adolescents and adults Filling date: 8 Sep 2025 Issue date: 26 Jan 2021 | 31 Mar 2017 | 26 Jan 2021 |
| Utility: POLYPEPTIDES THAT BIND COMPLEMENT COMPONENT C5 OR SERUM ALBUMIN AND FUSION PROTEINS THEREOF Filling date: 8 Sep 2025 Issue date: 24 Dec 2020 | 11 Jul 2018 | 24 Dec 2020 |
| Utility: TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA PATIENTS BY AN INHIBITOR OF COMPLEMENT Filling date: 8 Sep 2025 Issue date: 17 Dec 2020 | 23 Jan 2020 | 17 Dec 2020 |
| Utility: Lysosomal storage disease enzymes Filling date: 8 Sep 2025 Issue date: 8 Dec 2020 | 9 Jul 2019 | 8 Dec 2020 |
| Utility: HIGH CONCENTRATION ANTI-C5 ANTIBODY FORMULATIONS Filling date: 8 Sep 2025 Issue date: 26 Nov 2020 | 27 Jul 2018 | 26 Nov 2020 |
| Utility: Compositions and methods for treating craniosynostosis Filling date: 8 Sep 2025 Issue date: 3 Nov 2020 | 10 Jul 2015 | 3 Nov 2020 |
| Utility: DOSAGE AND ADMINISTRATION OF ANTI-C5 ANTIBODIES FOR TREATMENT OF GENERALIZED MYASTHENIA GRAVIS Filling date: 8 Sep 2025 Issue date: 22 Oct 2020 | 14 Feb 2020 | 22 Oct 2020 |
| Utility: METHODS OF TREATING MYOINTIMAL PROLIFERATION Filling date: 8 Sep 2025 Issue date: 1 Oct 2020 | 15 Jun 2017 | 1 Oct 2020 |
| Utility: METHODS FOR TREATING HYPOPHOSPHATASIA IN CHILDREN AND ADOLESCENTS Filling date: 8 Sep 2025 Issue date: 1 Oct 2020 | 27 Jun 2016 | 1 Oct 2020 |
| Utility: DOSAGE AND ADMINISTRATION OF ANTI-C5 ANTIBODIES FOR TREATMENT OF PATIENTS WITH MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS Filling date: 8 Sep 2025 Issue date: 20 Aug 2020 | 2 Oct 2018 | 20 Aug 2020 |
| Utility: METHODS OF IMPROVING CARDIOVASCULAR FUNCTION AND TREATING CARDIOVASCULAR DISEASE USING A RECOMBINANT ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE (NPP1) Filling date: 8 Sep 2025 Issue date: 20 Aug 2020 | 26 Sep 2018 | 20 Aug 2020 |
| Utility: DOSAGE AND ADMINISTRATION OF ANTI-C5 ANTIBODIES FOR TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) AND ATYPICAL HEMOLYTIC UREMIC SYNDROME (AHUS) Filling date: 8 Sep 2025 Issue date: 13 Aug 2020 | 26 Oct 2018 | 13 Aug 2020 |
| Utility: BIOMARKER SIGNATURE FOR PREDICTING TUMOR RESPONSE TO ANTI-CD200 THERAPY Filling date: 8 Sep 2025 Issue date: 23 Jul 2020 | 26 Sep 2018 | 23 Jul 2020 |
| Utility: METAL IMPACT ON MANUFACTURING OF ALKALINE PHOSPHATASES Filling date: 8 Sep 2025 Issue date: 16 Jul 2020 | 6 Jun 2017 | 16 Jul 2020 |
| Utility: Methods of shifting an isoelectric profile of a protein product and uses thereof Filling date: 8 Sep 2025 Issue date: 14 Jul 2020 | 19 Jan 2018 | 14 Jul 2020 |
| Utility: Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement Filling date: 8 Sep 2025 Issue date: 7 Jul 2020 | 28 Feb 2020 | 7 Jul 2020 |
| Utility: ANTI-C5A ANTIBODIES Filling date: 8 Sep 2025 Issue date: 2 Jul 2020 | 12 Sep 2019 | 2 Jul 2020 |
| Utility: TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA PATIENTS BY AN INHIBITOR OF COMPLEMENT Filling date: 8 Sep 2025 Issue date: 25 Jun 2020 | 28 Feb 2020 | 25 Jun 2020 |
| Utility: METHODS OF TREATING A SUBJECT WITH AN ALKALINE PHOSPHATASE DEFICIENCY Filling date: 8 Sep 2025 Issue date: 11 Jun 2020 | 19 Feb 2020 | 11 Jun 2020 |
| Utility: METHODS OF REPLICATING A LARGE SCALE ECULIZUMAB PRODUCTION CELL CULTURE Filling date: 8 Sep 2025 Issue date: 4 Jun 2020 | 10 Dec 2019 | 4 Jun 2020 |
| Utility: DOSAGE AND ADMINISTRATION OF ANTI-C5 ANTIBODIES FOR TREATMENT OF PROTEIN-LOSING ENTEROPATHY IN PATIENTS Filling date: 8 Sep 2025 Issue date: 4 Jun 2020 | 21 May 2018 | 4 Jun 2020 |
| Utility: ANTI-C5 ANTIBODIES HAVING IMPROVED PHARMACOKINETICS Filling date: 8 Sep 2025 Issue date: 21 May 2020 | 23 Jan 2020 | 21 May 2020 |
| Utility: METHODS FOR TREATING COMPLEMENT-ASSOCIATED DISORDERS Filling date: 8 Sep 2025 Issue date: 7 May 2020 | 11 Oct 2019 | 7 May 2020 |
| Utility: N-acetyl-alpha-D-glucosaminidase deficiency compositions and methods Filling date: 8 Sep 2025 Issue date: 28 Apr 2020 | 11 Oct 2017 | 28 Apr 2020 |
| Utility: EFFICACY OF AN ANTI-C5 ANTIBODY IN THE PREVENTION OF ANTIBODY MEDIATED REJECTION IN SENSITIZED RECIPIENTS OF A KIDNEY TRANSPLANT Filling date: 8 Sep 2025 Issue date: 23 Apr 2020 | 17 Apr 2018 | 23 Apr 2020 |
| Utility: METHODS FOR IDENTIFYING THE HEALTH STATE OF HYPOPHOSPHATASIA (HPP) PATIENTS Filling date: 8 Sep 2025 Issue date: 23 Apr 2020 | 10 Apr 2018 | 23 Apr 2020 |
| Utility: COMPOSITIONS COMPRISING AN ANTI-C5 ANTIBODY Filling date: 8 Sep 2025 Issue date: 2 Apr 2020 | 9 Oct 2019 | 2 Apr 2020 |
| Utility: METHODS FOR TREATING HYPOPHOSPHATASIA (HPP) IN ADULTS AND ADOLESCENTS Filling date: 8 Sep 2025 Issue date: 2 Apr 2020 | 29 Mar 2018 | 2 Apr 2020 |
| Utility: Methods of treating a subject with an alkaline phosphatase deficiency Filling date: 8 Sep 2025 Issue date: 31 Mar 2020 | 28 Jan 2016 | 31 Mar 2020 |
| Utility: TREATING SEIZURE WITH RECOMBINANT ALKALINE PHOSPHATASE Filling date: 8 Sep 2025 Issue date: 26 Mar 2020 | 18 Oct 2019 | 26 Mar 2020 |
| Utility: COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROMYELITIS OPTICA Filling date: 8 Sep 2025 Issue date: 26 Mar 2020 | 20 Sep 2019 | 26 Mar 2020 |
| Utility: Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement Filling date: 8 Sep 2025 Issue date: 17 Mar 2020 | 5 Jul 2017 | 17 Mar 2020 |
| Utility: Methods of treating atypical hemolytic uremic syndrome and paroxysmal nocturnal hemoglobinuria with anti-C5 antibodies Filling date: 8 Sep 2025 Issue date: 10 Mar 2020 | 14 Jan 2019 | 10 Mar 2020 |
| Utility: METHODS AND COMPOSITIONS FOR TREATING COMPLEMENT-ASSOCIATED DISORDERS Filling date: 8 Sep 2025 Issue date: 5 Mar 2020 | 20 Mar 2019 | 5 Mar 2020 |
| Utility: Compositions and methods relating to genomic modifications in avian primordial germ cells Filling date: 8 Sep 2025 Issue date: 3 Mar 2020 | 9 Aug 2017 | 3 Mar 2020 |
| Utility: LYSOSOMAL STORAGE DISEASE ENZYMES Filling date: 8 Sep 2025 Issue date: 27 Feb 2020 | 9 Jul 2019 | 27 Feb 2020 |
| Utility: ASSAY FOR C5B-9 DEPOSITION IN COMPLEMENT-ASSOCIATED DISORDERS Filling date: 8 Sep 2025 Issue date: 20 Feb 2020 | 26 Oct 2017 | 20 Feb 2020 |
| Utility: Recombinant human ADA2 and ADA2 fusion proteins and methods for treating ADA2 deficiencies Filling date: 8 Sep 2025 Issue date: 11 Feb 2020 | 17 Nov 2015 | 11 Feb 2020 |
| Utility: METHODS FOR REDUCING LIVER FIBROSIS AND TREATING LYSOSOMAL ACID LIPASE DEFICIENCY IN PATIENTS BASED ON ISHAK FIBROSIS STAGE Filling date: 8 Sep 2025 Issue date: 6 Feb 2020 | 28 Sep 2017 | 6 Feb 2020 |
| Utility: METHOD FOR SIMULTANEOUS QUANTIFICATION OF ALXN1210 AND ECULIZUMAB IN HUMAN SERUM OR URINE Filling date: 8 Sep 2025 Issue date: 30 Jan 2020 | 28 Mar 2018 | 30 Jan 2020 |
| Utility: Methods of replicating a large scale eculizumab production cell culture Filling date: 8 Sep 2025 Issue date: 28 Jan 2020 | 13 Oct 2015 | 28 Jan 2020 |
| Utility: COMPOSITIONS AND METHODS FOR INCREASING THE SERUM HALF-LIFE OF A THERAPEUTIC AGENT TARGETING COMPLEMENT C5 Filling date: 8 Sep 2025 Issue date: 23 Jan 2020 | 29 May 2019 | 23 Jan 2020 |
| Utility: Methods of treating tissue calcification Filling date: 8 Sep 2025 Issue date: 3 Dec 2019 | 18 Dec 2015 | 3 Dec 2019 |
