Option
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Employee Stock Option (right to buy) 27,308 $9.15 $249,868 Option
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 27,308 $9.15 $249,868 Option
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 27,308 $5.07 $138,452 Option
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Employee Stock Option (right to buy) 27,308 $4.08 $111,417 Sale
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 27,308 $18 $491,544 Option
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 30,000 $9.15 $274,500 Option
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 30,000 $9.15 $274,500 Option
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Employee Stock Option (right to buy) 30,000 $9.15 $274,500 Sale
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 30,000 $18.01 $540,240 Option
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Employee Stock Option (right to buy) 8,567 $9.15 $78,388 Option
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 8,567 $9.15 $78,388 Option
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 8,567 N/A N/A Sale
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 8,567 N/A N/A Option
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Employee Stock Option (right to buy) 8,567 $9.15 $78,388 Option
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Employee Stock Option (right to buy) 30,000 $9.15 $274,500 Option
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 30,000 N/A N/A Sale
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 30,000 N/A N/A Option
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Employee Stock Option (right to buy) 30,000 $9.15 $274,500 Sale
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 10,000 $11.47 $114,700 Sale
MCGUIRE TERRANCE director, 10 percent owner director, 10 percent owner
Common Stock 4,377 $31.54 $138,064 Sale
POLARIS VENTURE MANAGEMENT CO. VI, L.L.C. 10 percent owner 10 percent owner
Common Stock 4,377 N/A N/A Sale
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 10,000 $29.67 $296,650 Sale
YU CALVIN officer: Vice President, Finance officer: Vice President, Finance
Common Stock 1,343 $31.53 $42,345 Sale
YU CALVIN officer: Vice President, Finance officer: Vice President, Finance
Common Stock 1,343 N/A N/A Sale
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 10,000 $26.98 $269,770 Sale
KING ROBERT officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 15,000 N/A N/A Sale
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 10,000 $18.26 $182,600 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 62,183 $23.53 $1,463,166 Sale
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 10,000 N/A N/A Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 23,231 $23.52 $546,393 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 288,101 $11.9 $3,426,961 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 82,614 $11.83 $976,911 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 9,170 $23.1 $211,827 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 9,170 $23.1 $211,827 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 250,000 $24.5 $6,125,000 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 56,411 $24.66 $1,391,095 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 67,644 $24.45 $1,653,896 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 14,598 $26.05 $380,278 Sale
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 10,000 $23 $229,980 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 1,874,203 $26 $48,729,278 Sale
PAUL ROBERT officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 10,000 $29.41 $294,050 Sale
KING ROBERT officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 15,000 $29.43 $441,450 Option
YU CALVIN officer: Vice President, Finance officer: Vice President, Finance
Stock Option (right to buy) 10,225 $9.15 $93,559 Option
YU CALVIN officer: Vice President, Finance officer: Vice President, Finance
Common Stock 10,225 $9.15 $93,559 Sale
YU CALVIN officer: Vice President, Finance officer: Vice President, Finance
Common Stock 24,033 $35.02 $841,636 Sale
ONEY SABAH officer: Chief Business Officer officer: Chief Business Officer
Common Stock 19,900 $35.03 $697,097 Option
YU CALVIN officer: Vice President, Finance officer: Vice President, Finance
Stock Option (right to buy) 1,821 $9.15 $16,662 Option
YU CALVIN officer: Vice President, Finance officer: Vice President, Finance
Common Stock 1,821 $9.15 $16,662 Sale
YU CALVIN officer: Vice President, Finance officer: Vice President, Finance
Common Stock 2,621 $35 $91,735 Sale
ONEY SABAH officer: Chief Business Officer officer: Chief Business Officer
Common Stock 100 $35 $3,500