| Utility: ETHERS, SECONDARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 6 Aug 2020 | 11 Sep 2019 | 6 Aug 2020 |
| Utility: Method of treating conditions related to the PGI2 receptor Filling date: 8 Sep 2025 Issue date: 23 Jun 2020 | 6 Dec 2019 | 23 Jun 2020 |
| Utility: Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto Filling date: 8 Sep 2025 Issue date: 23 Jun 2020 | 6 Nov 2018 | 23 Jun 2020 |
| Utility: Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydroc- yclo-penta [b]indol-3-yl)acetic acid(Compound 1) for use in SIPI receptor-associated disorders Filling date: 8 Sep 2025 Issue date: 9 Jun 2020 | 9 Apr 2019 | 9 Jun 2020 |
| Utility: Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto Filling date: 8 Sep 2025 Issue date: 2 Jun 2020 | 2 Mar 2017 | 2 Jun 2020 |
| Utility: Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto Filling date: 8 Sep 2025 Issue date: 26 May 2020 | 6 Sep 2019 | 26 May 2020 |
| Utility: PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO- -PHENYL)-UREA AND CRYSTALLINE FORMS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 7 May 2020 | 26 Dec 2019 | 7 May 2020 |
| Utility: COMPOUNDS AND METHODS FOR TREATMENT OF NAFLD AND NASH Filling date: 8 Sep 2025 Issue date: 30 Apr 2020 | 19 Jun 2018 | 30 Apr 2020 |
| Utility: Cannabinoid receptor modulators Filling date: 8 Sep 2025 Issue date: 28 Apr 2020 | 8 Feb 2017 | 28 Apr 2020 |
| Utility: 5-HT.sub.2C receptor agonists and compositions and methods of use Filling date: 8 Sep 2025 Issue date: 21 Apr 2020 | 12 Mar 2019 | 21 Apr 2020 |
| Utility: METHOD OF TREATING CONDITIONS RELATED TO THE PGI2 RECEPTOR Filling date: 8 Sep 2025 Issue date: 9 Apr 2020 | 6 Dec 2019 | 9 Apr 2020 |
| Utility: 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE Filling date: 8 Sep 2025 Issue date: 12 Mar 2020 | 12 Mar 2019 | 12 Mar 2020 |
| Utility: Compounds and Methods for Treatment of Visceral Pain Filling date: 8 Sep 2025 Issue date: 12 Mar 2020 | 8 May 2018 | 12 Mar 2020 |
| Utility: Composition of a 5-HT2A serotonin receptor modulator useful for the treatment of disorders related thereto Filling date: 8 Sep 2025 Issue date: 10 Mar 2020 | 27 Sep 2018 | 10 Mar 2020 |
| Utility: CANNABINOID RECEPTOR MODULATORS Filling date: 8 Sep 2025 Issue date: 5 Mar 2020 | 17 Jun 2019 | 5 Mar 2020 |
| Utility: PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 13 Feb 2020 | 18 Apr 2019 | 13 Feb 2020 |
| Utility: Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro- -phenyl)-urea and crystalline forms related thereto Filling date: 8 Sep 2025 Issue date: 28 Jan 2020 | 7 Aug 2018 | 28 Jan 2020 |
| Utility: Method of treating conditions related to the PGI2 receptor Filling date: 8 Sep 2025 Issue date: 21 Jan 2020 | 22 Oct 2015 | 21 Jan 2020 |
| Utility: CANNABINOID RECEPTOR MODULATORS Filling date: 8 Sep 2025 Issue date: 16 Jan 2020 | 24 Sep 2019 | 16 Jan 2020 |
| Utility: COMPOUNDS AND METHODS FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE WITH EXTRA-INTESTINAL MANIFESTATIONS Filling date: 8 Sep 2025 Issue date: 16 Jan 2020 | 16 Feb 2018 | 16 Jan 2020 |
| Utility: COMPOUNDS AND METHODS FOR TREATMENT OF PRIMARY BILIARY CHOLANGITIS Filling date: 8 Sep 2025 Issue date: 2 Jan 2020 | 16 Feb 2018 | 2 Jan 2020 |
| Utility: MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 26 Dec 2019 | 6 Sep 2019 | 26 Dec 2019 |
| Utility: Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto Filling date: 8 Sep 2025 Issue date: 19 Nov 2019 | 4 Jun 2019 | 19 Nov 2019 |
| Utility: Modified-release dosage forms of 5-HT.sub.2C agonists useful for weight management Filling date: 8 Sep 2025 Issue date: 5 Nov 2019 | 7 Jan 2019 | 5 Nov 2019 |
| Utility: CRYSTALLINE L-ARGININE SALT OF (R)-2-(7-(4-CYCLOPENTYL-3- (TRIFLUOROMETHYL)BENZYLOXY)-1,2,3, 4-TETRAHYDROCYCLO-PENTA [B]INDOL-3-YL)ACETIC ACID(COMPOUND1) FOR USE IN SIPI RECEPTOR-ASSOCIATED DISORDERS Filling date: 8 Sep 2025 Issue date: 31 Oct 2019 | 9 Apr 2019 | 31 Oct 2019 |
| Utility: METHODS OF TREATING PAH WITH COMBINATIONS OF RALINEPAG AND OTHER AGENTS Filling date: 8 Sep 2025 Issue date: 24 Oct 2019 | 10 Nov 2017 | 24 Oct 2019 |
| Utility: Ethers, secondary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto Filling date: 8 Sep 2025 Issue date: 22 Oct 2019 | 22 Aug 2016 | 22 Oct 2019 |
| Utility: CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF CANNABINOID RECEPTOR MODULATORS Filling date: 8 Sep 2025 Issue date: 10 Oct 2019 | 10 Dec 2018 | 10 Oct 2019 |
| Utility: MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 26 Sep 2019 | 4 Jun 2019 | 26 Sep 2019 |
| Utility: MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 19 Sep 2019 | 5 Jun 2017 | 19 Sep 2019 |
| Utility: Modified-Release Dosage Forms of 5-Ht2c Agonists Useful for Weight Management Filling date: 8 Sep 2025 Issue date: 12 Sep 2019 | 7 Jan 2019 | 12 Sep 2019 |
| Utility: PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 5 Sep 2019 | 6 Nov 2018 | 5 Sep 2019 |
| Utility: 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 29 Aug 2019 | 1 Nov 2018 | 29 Aug 2019 |
| Utility: 5-HT.sub.2C receptor agonists and compositions and methods of use Filling date: 8 Sep 2025 Issue date: 27 Aug 2019 | 26 Apr 2016 | 27 Aug 2019 |
| Utility: MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Filling date: 8 Sep 2025 Issue date: 15 Aug 2019 | 15 Oct 2018 | 15 Aug 2019 |
| Utility: COMPOSITIONS COMPRISING PGI2-RECEPTOR AGONISTS AND PROCESSES FOR THE PREPARATION THEREOF Filling date: 8 Sep 2025 Issue date: 8 Aug 2019 | 16 Apr 2019 | 8 Aug 2019 |
