Sale
O'BRIEN PATRICK officer: COO and General Counsel officer: COO and General Counsel
Common Stock 400 $33.41 $13,364 Sale
O'BRIEN PATRICK officer: COO and General Counsel officer: COO and General Counsel
Common Stock 1,700 $32.65 $55,505 Sale
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 4,634 $30.74 $142,449 Sale
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 5,318 $31.25 $166,188 Sale
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 12,000 $28.54 $342,480 Sale
SAN MARTIN JAVIER officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 14,758 $28.73 $423,997 Sale
SAN MARTIN JAVIER officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 4,942 $29 $143,318 Sale
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 24,338 $24.21 $589,223 Sale
VAKIENER VICTORIA director director
Common Stock 1,550 $26.33 $40,812 Option
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 57,755 $4.75 $274,336 Sale
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 31,523 $28 $882,644 Sale
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 26,232 $28.27 $741,579 Option
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Stock Option (right to buy) 57,555 $4.75 $273,386 Sale
OLIVER TRACIE officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 8,925 $35.31 $315,142 Sale
HAMILTON JAMES C
Common Stock 3,000 $35.53 $106,590 Sale
MYSZKOWSKI KENNETH ALLEN officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 15,000 $36.2 $543,000 Sale
GIVEN DOUGLAS B director director
Common Stock 6,500 $40.9 $265,850 Option
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 50,000 $2.01 $100,500 Sale
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 24,008 $38.97 $935,592 Sale
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 25,992 $40.02 $1,040,200 Option
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Stock Option (right to buy) 50,000 $2.01 $100,500 Option
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 54,928 $2.01 $110,405 Sale
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 54,928 $39.14 $2,149,882 Option
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Stock Option (right to buy) 54,928 $2.01 $110,405 Sale
OLUKOTUN ADEOYE Y director director
Common Stock 11,350 $32.65 $370,578 Sale
GIVEN DOUGLAS B director director
Common Stock 875 $32.62 $28,542 Sale
WADDILL WILLIAM D. director director
Common Stock 3,200 $30 $96,000 Sale
O'BRIEN PATRICK officer: COO and General Counsel officer: COO and General Counsel
Common Stock 7,500 $37.39 $280,425 Sale
O'BRIEN PATRICK officer: COO and General Counsel officer: COO and General Counsel
Common Stock 7,500 $37.39 $280,425 Sale
HAMILTON JAMES C other other
Common Stock 6,573 $37.4 $245,830 Sale
HAMILTON JAMES C other other
Common Stock 7,230 $37.4 $270,402 Sale
HAMILTON JAMES C other other
Common Stock 247 $40.52 $10,008 Sale
HAMILTON JAMES C other other
Common Stock 300 $39.56 $11,868 Sale
HAMILTON JAMES C other other
Common Stock 3,682 $38.52 $141,831 Sale
HAMILTON JAMES C other other
Common Stock 1,642 $37.49 $61,559 Sale
HAMILTON JAMES C other other
Common Stock 136 $40.54 $5,513 Sale
HAMILTON JAMES C other other
Common Stock 300 $39.74 $11,922 Sale
HAMILTON JAMES C other other
Common Stock 2,837 $38.53 $109,310 Sale
HAMILTON JAMES C other other
Common Stock 1,194 $37.46 $44,727 Sale
O'BRIEN PATRICK officer: COO and General Counsel officer: COO and General Counsel
Common Stock 270 $40.53 $10,943 Sale
O'BRIEN PATRICK officer: COO and General Counsel officer: COO and General Counsel
Common Stock 300 $39.55 $11,865 Sale
O'BRIEN PATRICK officer: COO and General Counsel officer: COO and General Counsel
Common Stock 5,286 $38.58 $203,934 Sale
O'BRIEN PATRICK officer: COO and General Counsel officer: COO and General Counsel
Common Stock 2,894 $37.58 $108,757 Sale
O'BRIEN PATRICK officer: COO and General Counsel officer: COO and General Counsel
Common Stock 70 $40.8 $2,856 Sale
O'BRIEN PATRICK officer: COO and General Counsel officer: COO and General Counsel
Common Stock 500 $39.74 $19,870 Sale
O'BRIEN PATRICK officer: COO and General Counsel officer: COO and General Counsel
Common Stock 5,527 $38.54 $213,011 Sale
O'BRIEN PATRICK officer: COO and General Counsel officer: COO and General Counsel
Common Stock 2,653 $37.53 $99,567 Sale
MYSZKOWSKI KENNETH ALLEN officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 30,625 $40 $1,225,000 Option
O'BRIEN PATRICK officer: General Counsel officer: General Counsel
Stock Option (right to buy Common Stock) 32,000 $6.15 $196,800 Option
O'BRIEN PATRICK officer: General Counsel officer: General Counsel
Common Stock 32,000 $6.15 $196,800 
