Sale
SAN MARTIN JAVIER officer: Chief Medical Officer officer: Chief Medical Officer
COMMON STOCK 200 $30.62 $6,124 Sale
SAN MARTIN JAVIER officer: Chief Medical Officer officer: Chief Medical Officer
COMMON STOCK 19,300 $29.98 $578,614 Option
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 1,542 $31.21 $48,126 Option
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 39,082 $30.77 $1,202,553 Option
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Stock Option (right to buy Common Stock) 2,501 $14.54 $36,365 Option
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 2,501 $14.54 $36,365 Option
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Stock Option (right to buy Common Stock) 146,388 $5.19 $759,754 Sale
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 1,900 $50.51 $95,969 Sale
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 61,482 $50.9 $3,129,434 Sale
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 42,153 $52.28 $2,203,759 Sale
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 40,853 $53.11 $2,169,703 Option
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 146,388 $5.19 $759,754 Option
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Stock Option (right to buy Common Stock) 11,806 $5.19 $61,273 Option
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Common Stock 11,806 $5.19 $61,273 Sale
O'BRIEN PATRICK officer: General Counsel officer: General Counsel
Common Stock 316 $64.35 $20,335 Sale
O'BRIEN PATRICK officer: General Counsel officer: General Counsel
Common Stock 4,400 $63.75 $280,500 Sale
O'BRIEN PATRICK officer: General Counsel officer: General Counsel
Common Stock 5,000 $62.49 $312,450 Sale
O'BRIEN PATRICK officer: General Counsel officer: General Counsel
Common Stock 10,350 $61.88 $640,458 Sale
O'BRIEN PATRICK officer: General Counsel officer: General Counsel
Common Stock 12,434 $60.49 $752,133 Sale
HAMILTON JAMES C other other
Common Stock 60 $64.35 $3,861 Sale
HAMILTON JAMES C other other
Common Stock 700 $63.68 $44,576 Sale
HAMILTON JAMES C other other
Common Stock 1,100 $62.64 $68,904 Sale
HAMILTON JAMES C other other
Common Stock 2,100 $61.84 $129,864 Sale
HAMILTON JAMES C other other
Common Stock 2,290 $60.51 $138,568 Sale
MYSZKOWSKI KENNETH ALLEN officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 3,786 $63.95 $242,115 Sale
MYSZKOWSKI KENNETH ALLEN officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 3,778 $63.17 $238,656 Sale
MYSZKOWSKI KENNETH ALLEN officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 16,528 $62 $1,024,736 Sale
MYSZKOWSKI KENNETH ALLEN officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 15,908 $60.5 $962,434 Sale
HAMILTON JAMES C other other
Common Stock 500 $69.38 $34,690 Sale
HAMILTON JAMES C other other
Common Stock 649 $68.12 $44,210 Sale
HAMILTON JAMES C other other
Common Stock 802 $67.39 $54,047 Sale
HAMILTON JAMES C other other
Common Stock 7,469 $65.59 $489,892 Sale
HAMILTON JAMES C other other
Common Stock 9,955 $64.89 $645,980 Sale
PERRY MICHAEL S director director
Common Stock 272 $66.25 $18,020 Sale
PERRY MICHAEL S director director
Common Stock 1,600 $65.12 $104,192 Sale
PERRY MICHAEL S director director
Common Stock 2,628 $64.3 $168,980 Sale
DE BACKER MARIANNE director director
Common Stock 272 $66.25 $18,020 Sale
DE BACKER MARIANNE director director
Common Stock 1,984 $65.01 $128,980 Sale
DE BACKER MARIANNE director director
Common Stock 2,244 $64.25 $144,177 Sale
OLUKOTUN ADEOYE Y director director
Common Stock 244 $66.25 $16,165 Sale
OLUKOTUN ADEOYE Y director director
Common Stock 1,916 $65.04 $124,617 Sale
OLUKOTUN ADEOYE Y director director
Common Stock 1,890 $64.26 $121,451 Sale
WADDILL WILLIAM D. director director
Common Stock 272 $66.25 $18,020 Sale
WADDILL WILLIAM D. director director
Common Stock 2,128 $65.01 $138,341 Sale
WADDILL WILLIAM D. director director
Common Stock 2,100 $64.23 $134,883 Option
O'BRIEN PATRICK officer: General Counsel officer: General Counsel
Stock Option (right to buy Common Stock) 28,000 $6.15 $172,200 Option
O'BRIEN PATRICK officer: General Counsel officer: General Counsel
Common Stock 28,000 $6.15 $172,200 Purchase
GIVEN DOUGLAS B director director
Common Stock 655 $66.37 $43,472 Sale
FERRARI MAURO director director
Common Stock 3,400 $66.82 $227,188 Option
ANZALONE CHRISTOPHER RICHARD director, officer: Chief Exec.. director, officer: Chief Execut..
Stock Option (right to buy Common Stock) 11,806 $5.19 $61,273 
