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| Utility: DOUBLE-STRANDED NUCLEIC ACID INHIBITOR MOLECULES WITH SHORTENED SENSE STRANDS Filling date: 9 Sep 2025 Issue date: 9 Jun 2022 | 29 Apr 2020 | 9 Jun 2022 |
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| Utility: COMPOSITIONS AND METHODS FOR THE TREATMENT OF KRAS ASSOCIATED DISEASES OR DISORDERS Filling date: 9 Sep 2025 Issue date: 19 May 2022 | 27 Mar 2020 | 19 May 2022 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING HMGB1 EXPRESSION Filling date: 9 Sep 2025 Issue date: 10 Mar 2022 | 20 Dec 2019 | 10 Mar 2022 |
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| Utility: COMPOSITIONS AND METHODS FOR INHIBITING ALDH2 EXPRESSION Filling date: 9 Sep 2025 Issue date: 9 Dec 2021 | 15 Jan 2019 | 9 Dec 2021 |
| Utility: AMINE CATIONIC LIPIDS AND USES THEREOF Filling date: 9 Sep 2025 Issue date: 23 Sep 2021 | 8 Jun 2021 | 23 Sep 2021 |
| Utility: EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION Filling date: 9 Sep 2025 Issue date: 23 Sep 2021 | 4 Jun 2021 | 23 Sep 2021 |
| Utility: METHODS FOR TREATING HEPATITIS B INFECTION Filling date: 9 Sep 2025 Issue date: 16 Sep 2021 | 12 May 2021 | 16 Sep 2021 |
| Utility: BETA CATENIN NUCLEIC ACID INHIBITOR MOLECULE Filling date: 9 Sep 2025 Issue date: 5 Aug 2021 | 15 Apr 2021 | 5 Aug 2021 |
| Utility: PCSK9 TARGETING OLIGONUCLEOTIDES FOR TREATING HYPERCHOLESTEROLEMIA AND RELATED CONDITIONS Filling date: 9 Sep 2025 Issue date: 5 Aug 2021 | 1 Apr 2019 | 5 Aug 2021 |
| Utility: METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GLYCOLATE OXIDASE (HAO1) BY DOUBLE-STRANDED RNA Filling date: 9 Sep 2025 Issue date: 29 Jul 2021 | 25 Jan 2021 | 29 Jul 2021 |
| Utility: THERAPEUTIC INHIBITION OF LACTATE DEHYDROGENASE AND AGENTS THEREFOR Filling date: 9 Sep 2025 Issue date: 17 Jun 2021 | 1 Jul 2020 | 17 Jun 2021 |
| Utility: METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF ALPHA-1 ANTITRYPSIN BY DOUBLE-STRANDED RNA Filling date: 9 Sep 2025 Issue date: 17 Jun 2021 | 1 Jul 2020 | 17 Jun 2021 |
| Utility: METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF COMPLEMENT COMPONENT 5(C5) BY DOUBLE-STRANDED RNA Filling date: 9 Sep 2025 Issue date: 13 May 2021 | 17 Dec 2020 | 13 May 2021 |
| Utility: METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF ANTITHROMBIN 3 (AT3) BY DOUBLE-STRANDED RNA Filling date: 9 Sep 2025 Issue date: 1 Apr 2021 | 28 Feb 2020 | 1 Apr 2021 |
| Utility: EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION Filling date: 9 Sep 2025 Issue date: 4 Mar 2021 | 12 Nov 2020 | 4 Mar 2021 |
| Utility: METHODS AND COMPOSITIONS FOR INHIBITING EXPRESSION OF LDHA Filling date: 9 Sep 2025 Issue date: 4 Mar 2021 | 16 Sep 2020 | 4 Mar 2021 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING GYS2 EXPRESSION Filling date: 9 Sep 2025 Issue date: 4 Mar 2021 | 15 Feb 2019 | 4 Mar 2021 |
| Utility: COMPOSITIONS AND METHODS FOR THE TREATMENT OF A BETA-CATENIN-ASSOCIATED DISEASE OR DISORDER Filling date: 9 Sep 2025 Issue date: 21 Jan 2021 | 29 Sep 2020 | 21 Jan 2021 |
| Utility: METHODS AND COMPOSITIONS FOR TREATING BILE DUCT PAUCITY-ASSOCIATED CONDITIONS Filling date: 9 Sep 2025 Issue date: 14 Jan 2021 | 15 Feb 2019 | 14 Jan 2021 |
| Utility: REDUCING BETA-CATENIN EXPRESSION TO POTENTIATE IMMUNOTHERAPY Filling date: 9 Sep 2025 Issue date: 3 Dec 2020 | 28 Mar 2018 | 3 Dec 2020 |
| Utility: METHODS FOR TREATING HEPATITIS B INFECTION Filling date: 9 Sep 2025 Issue date: 29 Oct 2020 | 7 Jul 2020 | 29 Oct 2020 |
| Utility: METHODS FOR TREATING HEPATITIS B INFECTION Filling date: 9 Sep 2025 Issue date: 29 Oct 2020 | 7 Jul 2020 | 29 Oct 2020 |
| Utility: REDUCING BETA-CATENIN AND IDO EXPRESSION TO POTENTIATE IMMUNOTHERAPY Filling date: 9 Sep 2025 Issue date: 29 Oct 2020 | 3 Jan 2019 | 29 Oct 2020 |
| Utility: METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF KRAS BY ASYMMETRIC DOUBLE-STRANDED RNA Filling date: 9 Sep 2025 Issue date: 8 Oct 2020 | 22 Jun 2020 | 8 Oct 2020 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING HMGB1 EXPRESSION Filling date: 9 Sep 2025 Issue date: 24 Sep 2020 | 30 Apr 2020 | 24 Sep 2020 |
| Utility: METHODS AND COMPOSITIONS FOR INHIBITING EXPRESSION OF LDHA Filling date: 9 Sep 2025 Issue date: 10 Sep 2020 | 12 Oct 2018 | 10 Sep 2020 |
| Utility: BETA CATENIN NUCLEIC ACID INHIBITOR MOLECULE Filling date: 9 Sep 2025 Issue date: 27 Aug 2020 | 17 Oct 2018 | 27 Aug 2020 |
| Utility: METHODS FOR TREATING HEPATITIS B INFECTION Filling date: 9 Sep 2025 Issue date: 4 Jun 2020 | 14 Feb 2020 | 4 Jun 2020 |
| Utility: LIGAND-MODIFIED DOUBLE-STRANDED NUCLEIC ACIDS Filling date: 9 Sep 2025 Issue date: 30 Jan 2020 | 29 Aug 2019 | 30 Jan 2020 |
| Utility: METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GLYCOLATE OXIDASE (HAO1) BY DOUBLE-STRANDED RNA Filling date: 9 Sep 2025 Issue date: 2 Jan 2020 | 20 Aug 2019 | 2 Jan 2020 |
| Utility: METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF APLHA-1 ANTITRYPSIN BY DOUBLE-STRANDED RNA Filling date: 9 Sep 2025 Issue date: 26 Dec 2019 | 28 Jun 2019 | 26 Dec 2019 |
| Utility: THERAPEUTIC INHIBITION OF LACTATE DEHYDROGENASE AND AGENTS THEREFOR Filling date: 9 Sep 2025 Issue date: 24 Oct 2019 | 15 Mar 2019 | 24 Oct 2019 |
| Utility: DOUBLE-STRANDED NUCLEIC ACID INHIBITOR MOLECULES MODIFIED WITH TM-INCREASING NUCLEOTIDES Filling date: 9 Sep 2025 Issue date: 17 Oct 2019 | 11 Apr 2019 | 17 Oct 2019 |