Sale
BRAZZELL ROMULUS K officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,034 N/A N/A Sale
REUMUTH MARY officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 2,452 $5.77 $14,148 Sale
TRACHTENBERG ERIC officer: See Remarks officer: See Remarks
Common Stock 2,452 N/A N/A Sale
CHEN HONGMING officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,452 $5.77 $14,148 Option
CHEN HONGMING officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy 9,500 $2.3 $21,850 Option
CHEN HONGMING officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 9,500 $2.3 $21,850 Option
CHEN HONGMING officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 47,000 $2.3 $108,100 Option
CHEN HONGMING officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 47,000 $2.3 $108,100 Purchase
BAZEMORE TODD officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 40 $7.6 $304 Option
TRACHTENBERG ERIC officer: See Remarks officer: See Remarks
Stock Option (right to buy) 28,901 $5.19 $149,996 Option
TRACHTENBERG ERIC officer: See Remarks officer: See Remarks
Common Stock 28,901 $5.19 $149,996 Option
REUMUTH MARY officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 43,477 $3.03 $131,648 Option
REUMUTH MARY officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 11,520 $2.3 $26,496 Purchase
BAZEMORE TODD officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 2 $13.39 $27 Option
BRAZZELL ROMULUS K officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (right to buy) 49,524 $2.01 $99,543 Option
BRAZZELL ROMULUS K officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 67,771 $2.11 $142,793 Option
BRAZZELL ROMULUS K officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 67,771 N/A N/A Option
BRAZZELL ROMULUS K officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (right to buy) 49,524 N/A N/A Option
CHEN HONGMING officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 31,000 $2.3 $71,300 Option
CHEN HONGMING officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 31,000 $2.3 $71,300 Purchase
BAZEMORE TODD officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 10,000 $5.75 $57,500 Purchase
RA CAPITAL MANAGEMENT, L.P. director, 10 percent owner director, 10 percent owner
Common Stock 6,337,135 $7.89 $49,999,995 Purchase
SHAH RAJEEV M. director, 10 percent owner director, 10 percent owner
Common Stock 6,337,135 $7.89 $49,999,995 Purchase
GRUNBERG GREGORY director director
Common Stock 2,534,854 $7.89 $19,999,998 Option
ROSEN HOWARD B director director
Stock Option (right to buy) 2,880 $0.68 $1,958 Option
ROSEN HOWARD B director director
Common Stock 4,824 $0.58 $2,774 Option
ROSEN HOWARD B director director
Common Stock 4,824 $0.58 $2,774 Purchase
ROSEN HOWARD B director director
Common stock 5,000 $5.42 $27,100 Purchase
GRUNBERG GREGORY director director
Common Stock 606,060 $8.25 $4,999,995 Purchase
SHAH RAJEEV M. director, 10 percent owner director, 10 percent owner
Common Stock 2,424,242 $8.25 $19,999,997 Purchase
RA CAPITAL MANAGEMENT, LLC
Common Stock 2,424,242 $8.25 $19,999,997 Option
CHEN HONGMING officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (right to buy) 9,769 $2.27 $22,176 Option
CHEN HONGMING officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 9,769 $2.27 $22,176 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 25,000 $12.93 $323,250 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 37,840 $14.73 $557,383 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 22,840 $14.99 $342,372 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 339,400 $15 $5,091,000 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 50,000 $14.99 $749,500 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 22,760 $14.93 $339,807 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 64,637 $14.91 $963,738 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 4,363 $14.99 $65,401 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 75,000 $14.98 $1,123,500 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 74,931 $14.95 $1,120,218 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 66,800 $14.95 $998,660 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 41,700 $13.65 $569,205 Purchase
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 170,338 $12.83 $2,185,437 Option
BRAZZELL ROMULUS K officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (right to buy) 108,725 $1.75 $190,269 Option
BRAZZELL ROMULUS K officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 108,725 $1.75 $190,269 Purchase
GRUNBERG GREGORY director director
Common Stock 215,000 $15 $3,225,000 Purchase
RA CAPITAL MANAGEMENT, LLC
Common Stock 533,333 $15 $7,999,995