Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 74,844 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 166,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 352,750 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 41,500 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 21,829 N/A N/A Sale
LANPHIER EDWARD O II director director
Common Stock 25,000 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 21,829 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 3,055 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 116,992 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 83,000 N/A N/A Sale
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 15,000 N/A N/A Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 13,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 3,403 N/A N/A Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Employee Stock Option (Right to Buy) 13,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 69,856 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 121,876 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 33,667 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 179,031 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 195,126 N/A N/A Sale
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 250,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Employee Stock Option (Right to Buy) 15,000 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 84,000 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 256,187 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Employee Stock Option (Right to Buy) 15,000 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 210,013 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Common Stock 15,000 N/A N/A Sale
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Common Stock 13,000 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 84,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Employee Stock Option (Right to Buy) 15,000 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 101,808 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Sale
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 17,808 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 34,440 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 52,161 N/A N/A Option
LANPHIER EDWARD O II director director
Common Stock 50,000 N/A N/A Sale
RAMASASTRY SAIRA director director
Common Stock 10,000 N/A N/A Option
RAMASASTRY SAIRA director director
Employee Stock Option (Right to Buy) 10,000 N/A N/A Option
RAMASASTRY SAIRA director director
Common Stock 10,000 N/A N/A Sale
LANPHIER EDWARD O II director director
Common Stock 50,000 N/A N/A Option
LANPHIER EDWARD O II director director
Employee Stock Option (Right to Buy) 50,000 N/A N/A Option
MENTO STEVEN J director director
Common Stock 9,722 N/A N/A Option
MENTO STEVEN J director director
Employee Stock Option (Right to Buy) 9,722 N/A N/A Sale
MENTO STEVEN J director director
Common Stock 6,103 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 71,319 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 123,480 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 12,522 N/A N/A Sale
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 10,000 N/A N/A