Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 10,000 N/A N/A Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Employee Stock Option (Right to Buy) 10,000 N/A N/A Sale
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Option
CLEVELAND PAUL B director director
Common Stock 7,278 N/A N/A Sale
CLEVELAND PAUL B director director
Common Stock 7,278 N/A N/A Option
CLEVELAND PAUL B director director
Stock Option (Right to Buy) 7,278 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Employee Stock Option (Right to Buy) 15,000 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Employee Stock Option (Right to Buy) 13,000 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Common Stock 13,000 N/A N/A Sale
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Common Stock 13,000 N/A N/A Sale
LANPHIER EDWARD O II director director
Common Stock 25,000 N/A N/A Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 10,000 N/A N/A Sale
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 10,000 N/A N/A Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Employee Stock Option (Right to Buy) 10,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Sale
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Employee Stock Option (Right to Buy) 15,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Employee Stock Option (Right to Buy) 15,000 N/A N/A Sale
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 7,000 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Common Stock 13,000 N/A N/A Sale
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Common Stock 13,000 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Employee Stock Option (Right to Buy) 13,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 368,870 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 5,012 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 111,363 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 23,040 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 74,035 N/A N/A Sale
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 10,000 N/A N/A Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Employee Stock Option (Right to Buy) 10,000 N/A N/A Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 10,000 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 19,200 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 19,200 N/A N/A Sale
LANPHIER EDWARD O II director director
Common Stock 25,000 N/A N/A Option
CLEVELAND PAUL B director director
Stock Option (Right to Buy) 8,000 N/A N/A Sale
CLEVELAND PAUL B director director
Common Stock 8,000 N/A N/A Option
CLEVELAND PAUL B director director
Common Stock 8,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 3,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Employee Stock Option (Right to Buy) 3,000 N/A N/A Sale
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 3,000 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Common Stock 15,000 N/A N/A Sale
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Common Stock 15,000 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Employee Stock Option (Right to Buy) 15,000 N/A N/A Option
LARSON JOHN WILLIAM director director
Stock Options (Right to purchase) 10,000 N/A N/A Option
LARSON JOHN WILLIAM director director
Common Stock 10,000 N/A N/A Sale
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 6,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 6,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Employee Stock Option (Right to Buy) 6,000 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Common Stock 15,000 N/A N/A