Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 10,000 N/A N/A Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Employee Stock Option (Right to Buy) 10,000 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 258,377 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 31,531 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 42,001 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 84,000 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 42,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 32,196 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Common Stock 15,000 N/A N/A Sale
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Common Stock 13,000 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Employee Stock Option (Right to Buy) 15,000 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 74,194 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 35,319 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 6,720 N/A N/A Option
LANPHIER EDWARD O II director director
Employee Stock Option (Right to Buy) 50,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 11,172 N/A N/A Sale
LANPHIER EDWARD O II director director
Common Stock 50,000 N/A N/A Option
LANPHIER EDWARD O II director director
Common Stock 50,000 N/A N/A Option
RINGO WILLIAM R director director
Stock Option (Right to Buy) 25,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 15,380 N/A N/A Sale
RINGO WILLIAM R director director
Common Stock 25,000 N/A N/A Option
RINGO WILLIAM R director director
Common Stock 25,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 15,409 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 42,000 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 42,000 N/A N/A Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Employee Stock Option (Right to Buy) 10,000 N/A N/A Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 10,000 N/A N/A Sale
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 10,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 34,688 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 7,312 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 42,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Employee Stock Option (Right to Buy) 15,000 N/A N/A Sale
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Call Option (right to buy) 8,275 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Call Option (obligation to sell) 8,275 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Employee Stock Option (Right to Buy) 15,000 N/A N/A Sale
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Common Stock 13,000 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Common Stock 15,000 N/A N/A Option
CLEVELAND PAUL B director director
Stock Option (Right to Buy) 8,333 N/A N/A Sale
LANPHIER EDWARD O II director director
Common Stock 50,000 N/A N/A Option
CLEVELAND PAUL B director director
Common Stock 8,333 N/A N/A Option
LANPHIER EDWARD O II director director
Employee Stock Option (Right to Buy) 5,281 N/A N/A Option
LANPHIER EDWARD O II director director
Common Stock 50,000 N/A N/A Sale
CLEVELAND PAUL B director director
Common Stock 8,333 N/A N/A Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Employee Stock Option (Right to Buy) 10,000 N/A N/A Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 10,000 N/A N/A Sale
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 10,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 72,440 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Employee Stock Option (Right to Buy) 15,000 N/A N/A