Sale
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 82,700 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Employee Stock Option (Right to Buy) 15,000 N/A N/A Sale
RAMASASTRY SAIRA director director
Common Stock 5,550 N/A N/A Option
RAMASASTRY SAIRA director director
Employee Stock Option (Right to Buy) 5,550 N/A N/A Option
RAMASASTRY SAIRA director director
Common Stock 5,550 N/A N/A Sale
LANPHIER EDWARD O II director director
Common Stock 25,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 250,500 N/A N/A Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 13,000 N/A N/A Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Employee Stock Option (Right to Buy) 13,000 N/A N/A Sale
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 15,000 N/A N/A Option
MENTO STEVEN J director director
Common Stock 5,834 N/A N/A Option
MENTO STEVEN J director director
Employee Stock Option (Right to Buy) 5,834 N/A N/A Sale
MENTO STEVEN J director director
Common Stock 4,328 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 83,500 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 135,101 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 1,085,463 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 70,640 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 76,833 N/A N/A Sale
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Employee Stock Option (Right to Buy) 15,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 65,884 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 155,675 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 148,689 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Employee Stock Option (Right to Buy) 15,000 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Common Stock 15,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 263,437 N/A N/A Sale
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Common Stock 13,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 51,597 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 56,396 N/A N/A Sale
LANPHIER EDWARD O II director director
Common Stock 25,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 56,060 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 29,659 N/A N/A Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 13,000 N/A N/A Option
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Employee Stock Option (Right to Buy) 13,000 N/A N/A Sale
WOLFF HENRY WARD officer: Exec VP & CFO officer: Exec VP & CFO
Common Stock 15,000 N/A N/A Sale
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 83,300 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 83,300 N/A N/A Sale
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Common Stock 15,000 N/A N/A Option
GREGORY PHILIP D officer: SVP of Research & CSO officer: SVP of Research & CSO
Employee Stock Option (Right to Buy) 15,000 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 124,500 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Employee Stock Option (Right to Buy) 15,000 N/A N/A Option
LARSON JOHN WILLIAM director director
Common Stock 10,000 N/A N/A Option
LARSON JOHN WILLIAM director director
Stock Option (Right to Buy) 10,000 N/A N/A Option
ANDO DALE G officer: VP, Therapeutic Dev. & CMO officer: VP, Therapeutic Dev. &..
Common Stock 15,000 N/A N/A Sale
LARSON JOHN WILLIAM director director
Common Stock 10,000 N/A N/A Purchase
RA CAPITAL MANAGEMENT, LLC 10 percent owner 10 percent owner
Common Stock 74,844 N/A N/A