Sale
NSV PARTNERS III LP 10 percent owner 10 percent owner
Common Stock 146,825 $32.94 $4,836,856 Sale
SUBRAMANIAM SOMU director, 10 percent owner director, 10 percent owner
Common Stock 153,175 $33.61 $5,148,212 Sale
NSV PARTNERS III LP 10 percent owner 10 percent owner
Common Stock 153,175 $33.61 $5,148,212 Option
SANDBORN WILLIAM J. officer: President and Chief Medical O.. officer: President and Chief Me..
Common Stock 20,922 $0.2 $4,184 Sale
SANDBORN WILLIAM J. officer: President and Chief Medical O.. officer: President and Chief Me..
Common Stock 20,922 $33.87 $708,628 Option
SANDBORN WILLIAM J. officer: President and Chief Medical O.. officer: President and Chief Me..
Stock Option (right to buy) 3,189 $1.73 $5,517 Option
SANDBORN WILLIAM J. officer: President and Chief Medical O.. officer: President and Chief Me..
Stock Option (right to buy) 20,922 $0.2 $4,184 Sale
SANDBORN WILLIAM J. officer: President and Chief Medical O.. officer: President and Chief Me..
Common Stock 21,760 $33.87 $737,076 Option
SANDBORN WILLIAM J. officer: President and Chief Medical O.. officer: President and Chief Me..
Common Stock 16,180 $0.2 $3,236 Option
SANDBORN WILLIAM J. officer: President and Chief Medical O.. officer: President and Chief Me..
Common Stock 2,391 $3.54 $8,464 Option
SANDBORN WILLIAM J. officer: President and Chief Medical O.. officer: President and Chief Me..
Common Stock 3,189 $1.73 $5,517 Option
SANDBORN WILLIAM J. officer: President and Chief Medical O.. officer: President and Chief Me..
Stock Option (right to buy) 16,180 $0.2 $3,236 Sale
NUSS JOHN officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 35,000 $34.32 $1,201,095 Sale
KRUEGER CHRISTOPHER W officer: Chief Business Officer officer: Chief Business Officer
Common Stock 30,000 $34.46 $1,033,680 Sale
NUSS JOHN officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 46,706 $28.16 $1,315,334 Sale
NUSS JOHN officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 3,294 $29.14 $95,997 Sale
MOHAN RAJU director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 3,107 $29.15 $90,569 Sale
MOHAN RAJU director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 19,896 $28.33 $563,554 Sale
MOHAN RAJU director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 276,997 $29.02 $8,037,068 Option
AUSTER MARTIN officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 50,000 $3.45 $172,500 Sale
AUSTER MARTIN officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 97,647 $29.01 $2,832,642 Option
AUSTER MARTIN officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 50,000 $3.45 $172,500 Sale
KRUEGER CHRISTOPHER W officer: Chief Business Officer officer: Chief Business Officer
Common Stock 50,000 $29.02 $1,450,750 Sale
SUBRAMANIAM SOMU director, 10 percent owner director, 10 percent owner
Common Stock 129,317 $29.01 $3,751,098 Sale
NSV PARTNERS III LP 10 percent owner 10 percent owner
Common Stock 129,317 $29.01 $3,751,098 Sale
NSV PARTNERS III LP 10 percent owner 10 percent owner
Common Stock 143,228 $29.02 $4,155,760 Sale
SUBRAMANIAM SOMU director, 10 percent owner director, 10 percent owner
Common Stock 143,228 $29.02 $4,155,760 Sale
SUBRAMANIAM SOMU director, 10 percent owner director, 10 percent owner
Common Stock 3,935 $29.08 $114,426 Sale
NSV PARTNERS III LP 10 percent owner 10 percent owner
Common Stock 3,935 $29.08 $114,426 Option
KRUEGER CHRISTOPHER W officer: Chief Business Officer officer: Chief Business Officer
Stock Option (right to buy) 96,778 $0.2 $19,356 Option
KRUEGER CHRISTOPHER W officer: Chief Business Officer officer: Chief Business Officer
Stock Option (right to buy) 72,583 $0.2 $14,517 Option
KRUEGER CHRISTOPHER W officer: Chief Business Officer officer: Chief Business Officer
Common Stock 96,778 $0.2 $19,356 Option
KRUEGER CHRISTOPHER W officer: Chief Business Officer officer: Chief Business Officer
Common Stock 72,583 $0.2 $14,517 Purchase
VENBIO GLOBAL STRATEGIC FUND III, L.P. other: See Remarks other: See Remarks
Common Stock 312,500 $16 $5,000,000 Purchase
CORMORANT ASSET MANAGEMENT, LP other: Former 10% Owner other: Former 10% Owner
Common Stock 625,000 $16 $10,000,000 Purchase
ROYSTON AARON director, 10 percent owner director, 10 percent owner
Common Stock 312,500 $16 $5,000,000