Option
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Common Stock 15,000 $4.03 $60,450 Sale
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Common Stock 15,000 N/A N/A Option
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Stock Option (Right to Buy) 15,000 N/A N/A Option
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 26,000 $5.5 $143,000 Sale
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 26,000 $20.58 $534,950 Option
NEAL JAMES R director, officer: CEO director, officer: CEO
Stock Option (Right to Buy) 26,000 N/A N/A Sale
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 26,000 $41.6 $1,081,522 Sale
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Common Stock 15,000 $41.54 $623,025 Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
8.625% Series A Cumulative Perpetual Preferred Stock 200,000 $25 $5,000,000 Purchase
PERRY MATTHEW D director, other: See Explanation of Respon.. director, other: See Explanatio..
8.625% Series A Cumulative Perpetual Preferred Stock 200,000 $25 $5,000,000 Option
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Common Stock 5,125 $32.93 $168,751 Sale
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Common Stock 5,125 N/A N/A Option
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Stock Option (Right to Buy) 5,125 $32.93 $168,751 Option
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 13,126 $32.96 $432,659 Sale
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 13,126 $32.96 $432,659 Option
NEAL JAMES R director, officer: CEO director, officer: CEO
Stock Option (Right to Buy) 13,126 $32.96 $432,659 Option
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Common Stock 6,875 $4.03 $27,706 Sale
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Common Stock 6,875 $32.91 $226,243 Option
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Stock Option (Right to Buy) 6,875 N/A N/A Option
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 6,874 N/A N/A Sale
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 6,874 $32.91 $226,203 Option
NEAL JAMES R director, officer: CEO director, officer: CEO
Stock Option (Right to Buy) 6,874 N/A N/A Sale
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 6,874 $32.91 $226,203 Sale
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Common Stock 8,000 $26.74 $213,904 Option
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Stock Option (Right to Buy) 8,000 N/A N/A Option
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 10,000 N/A N/A Sale
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 10,000 $26.7 $267,020 Option
NEAL JAMES R director, officer: CEO director, officer: CEO
Stock Option (Right to Buy) 10,000 $5.5 $55,000 Option
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Common Stock 8,000 $4.03 $32,240 Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 17,089 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 11,951 $18.45 $220,448 Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 11,951 $18.45 $220,448 Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 22,328 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 7,737 $18.77 $145,231 Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 7,737 $18.77 $145,231 Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 17,572 $9.43 $165,757 Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 16,005 $18.48 $295,788 Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 2,044 $9.59 $19,594 Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 5,687 $9.87 $56,148 Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 11,683 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 10,805 $9.66 $104,387 Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 1,772 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 3,496 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 895 $19.27 $17,246 Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 21,922 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 1,050 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 4,050 $17.34 $70,235 Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 8,264 N/A N/A Purchase
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Shares 1,000 N/A N/A Purchase
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Shares 1,000 N/A N/A