Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 4,439 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 8,113 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 10,164 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 100,000 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 373,195 N/A N/A Option
NEAL JAMES R director, officer: CEO director, officer: CEO
Stock Option (Right to Buy) 4,348 N/A N/A Sale
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 4,348 N/A N/A Option
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 4,348 N/A N/A Option
NEAL JAMES R director, officer: CEO director, officer: CEO
Stock Option (right to buy) 5,452 N/A N/A Sale
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 5,452 N/A N/A Option
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 5,452 N/A N/A Option
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Stock Option (right to buy) 4,171 N/A N/A Sale
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Common Stock 4,171 N/A N/A Option
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Common Stock 4,171 N/A N/A Option
NEAL JAMES R director, officer: CEO director, officer: CEO
Stock Option (right to buy) 6,370 N/A N/A Sale
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 6,370 N/A N/A Option
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 6,370 N/A N/A Option
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Stock Option (right to buy) 3,829 N/A N/A Sale
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Common Stock 3,829 N/A N/A Option
BURNS THOMAS M. officer: SVP, Finance & CFO officer: SVP, Finance & CFO
Common Stock 3,829 N/A N/A Option
NEAL JAMES R director, officer: CEO director, officer: CEO
Stock Option (right to buy) 3,830 N/A N/A Sale
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 3,830 N/A N/A Option
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Stock 3,830 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 13,816 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 3,797 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 10,300 N/A N/A Sale
VAN NESS W DENMAN director director
Common Stock 130 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 25,000 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 24,253 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 2,810 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 9,400 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 18,081 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 32,015 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 10,927 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 4,171 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 806 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 4,823 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 10,016 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 8,288 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 11,396 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 25,000 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 37,482 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 9,771 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 10,849 N/A N/A Purchase
BVF PARTNERS L P/IL director, 10 percent owner, other: See.. director, 10 percent owner, oth..
Common Stock, $0.0075 par value per share 21,141 N/A N/A Option
VAN NESS W DENMAN director director
Non-Qualified Share Option (right to buy) 7,693 N/A N/A Sale
VAN NESS W DENMAN director director
Common Shares 5,528 N/A N/A Option
VAN NESS W DENMAN director director
Common Shares 7,693 N/A N/A Option
VAN NESS W DENMAN director director
Common Shares 7,693 $7.62 $58,582 Purchase
NEAL JAMES R director, officer: CEO director, officer: CEO
Common Shares 4,000 N/A N/A