Option
VARIAN JOHN director director
Common Shares 10,000 N/A N/A Option
VARIAN JOHN director director
Incentive Share Option (right to buy) 10,000 N/A N/A Option
VARIAN JOHN director director
Incentive Share Option (right to buy) 10,000 N/A N/A Option
VARIAN JOHN director director
Common Shares 10,000 N/A N/A Sale
VARIAN JOHN director director
Common Shares 10,000 N/A N/A Option
KURLAND FRED officer: CFO & VP Finance officer: CFO & VP Finance
Restricted Stock Units 4,656 N/A N/A Option
KURLAND FRED officer: CFO & VP Finance officer: CFO & VP Finance
Common Shares 29,938 N/A N/A Sale
RUBIN PAUL D officer: Sr. VP Clinical Dev. & CMO officer: Sr. VP Clinical Dev. &..
Common Shares 32,742 N/A N/A Option
KURLAND FRED officer: CFO & VP Finance officer: CFO & VP Finance
Restricted Stock Units 10,875 N/A N/A Option
SCANNON PATRICK J MD PHD officer: Exec. VP & CSO, other: E.. officer: Exec. VP & CSO, other:..
Restricted Stock Units 9,500 N/A N/A Option
SCANNON PATRICK J MD PHD officer: Exec. VP & CSO, other: E.. officer: Exec. VP & CSO, other:..
Common Shares 9,500 N/A N/A Option
RUBIN PAUL D officer: Sr. VP Clinical Dev. & CMO officer: Sr. VP Clinical Dev. &..
Restricted Stock Units 30,346 N/A N/A Option
VARIAN JOHN director director
Restricted Stock Units 36,907 N/A N/A Option
VARIAN JOHN director director
Common Shares 36,907 N/A N/A Option
KLEIN THOMAS officer: Chief Commercial Officer officer: Chief Commercial Officer
Restricted Stock Units 80,667 N/A N/A Option
KLEIN THOMAS officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Shares 80,667 N/A N/A Option
KURLAND FRED officer: CFO & VP Finance officer: CFO & VP Finance
Common Shares 10,875 N/A N/A Option
RUBIN PAUL D officer: Sr. VP Clinical Dev. & CMO officer: Sr. VP Clinical Dev. &..
Common Shares 30,346 N/A N/A Sale
VARIAN JOHN director director
Common Shares 10,000 N/A N/A Option
VARIAN JOHN director director
Common Shares 10,000 N/A N/A Option
VARIAN JOHN director director
Incentive Share Option (right to buy) 10,000 N/A N/A Option
VARIAN JOHN director director
Common Shares 10,000 N/A N/A Sale
VARIAN JOHN director director
Common Shares 10,000 N/A N/A Option
VARIAN JOHN director director
Incentive Share Option (right to buy) 10,000 N/A N/A Sale
SCANNON PATRICK J MD PHD officer: Exec. VP & CSO, other: E.. officer: Exec. VP & CSO, other:..
Common Shares 5,000 N/A N/A Sale
VARIAN JOHN director director
Common Shares 10,000 N/A N/A Option
VARIAN JOHN director director
Common Shares 10,000 N/A N/A Option
VARIAN JOHN director director
Incentive Share Option (right to buy) 10,000 N/A N/A Sale
BAKER BROS. ADVISORS LP other: Former 10% owner other: Former 10% owner
Common Stock 1,000,000 N/A N/A Sale
BAKER BROS. ADVISORS LP other: Former 10% owner other: Former 10% owner
Common Stock 1,003,300 N/A N/A Sale
SCANNON PATRICK J MD PHD officer: Exec. VP & CSO, other: E.. officer: Exec. VP & CSO, other:..
Common Shares 5,000 N/A N/A Sale
BAKER BROS. ADVISORS LP other: Former 10% owner other: Former 10% owner
Common Stock 212,100 N/A N/A Sale
BAKER BROS. ADVISORS LP other: Former 10% owner other: Former 10% owner
Common Stock 391,900 N/A N/A Sale
BAKER BROS. ADVISORS LP other: Former 10% owner other: Former 10% owner
Common Stock 221,000 N/A N/A Sale
BAKER BROS. ADVISORS LP other: Former 10% owner other: Former 10% owner
Common Stock 131,100 N/A N/A Sale
BAKER BROS. ADVISORS LP other: Former 10% owner other: Former 10% owner
Common Stock 752,900 N/A N/A Sale
BAKER BROS. ADVISORS LP other: Former 10% owner other: Former 10% owner
Common Stock 165,700 N/A N/A Sale
BAKER BROS. ADVISORS LP other: Former 10% owner other: Former 10% owner
Common Stock 686,500 N/A N/A Sale
BAKER BROS. ADVISORS LP other: Former 10% owner other: Former 10% owner
Common Stock 319,200 N/A N/A Option
RUBIN PAUL D officer: Sr. VP Clinical Dev. & CMO officer: Sr. VP Clinical Dev. &..
Incentive Share Option (right to buy) 1,600 N/A N/A Option
RUBIN PAUL D officer: Sr. VP Clinical Dev. & CMO officer: Sr. VP Clinical Dev. &..
Common Shares 1,600 N/A N/A Sale
BAKER BROS. ADVISORS LP other: Former 10% owner other: Former 10% owner
Common Stock 460,800 N/A N/A Sale
VARIAN JOHN director director
Common Shares 10,000 N/A N/A Option
VARIAN JOHN director director
Incentive Share Option (right to buy) 10,000 N/A N/A Sale
RUBIN PAUL D officer: Sr. VP Clinical Dev. & CMO officer: Sr. VP Clinical Dev. &..
Common Shares 1,600 N/A N/A Option
VARIAN JOHN director director
Common Shares 10,000 N/A N/A Option
LIMBER JOSEPH M director director
Restricted Stock Units 5,600 N/A N/A Sale
BAKER BROS. ADVISORS LP other: Former 10% owner other: Former 10% owner
Common Stock 253,800 N/A N/A Option
LIMBER JOSEPH M director director
Common Shares 5,600 N/A N/A Sale
BAKER BROS. ADVISORS LP other: Former 10% owner other: Former 10% owner
Common Stock 392,353 N/A N/A