Sale
MICHELI FRANCESCO 10 percent owner 10 percent owner
Common Stock 318,695 $320 $101,982,400 Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Common Stock 2,000 $10.4 $20,800 Sale
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Common Stock 2,000 $284.1 $568,200 Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Option to purchase Common Stock 2,000 $10.4 $20,800 Sale
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 879 $321.95 $282,997 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 5,948 $10.4 $61,859 Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Restricted Stock Units 1,298 N/A N/A Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common stock 1,298 N/A N/A Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Restricted Stock Units 649 N/A N/A Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Common stock 649 N/A N/A Option
PRUZANSKI MARK director director
Restricted Stock Units 4,868 N/A N/A Option
PRUZANSKI MARK director director
Common stock 4,868 N/A N/A Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Options to Purchase Common Stock 4,326 $10.4 $44,990 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Restricted Stock Units 1,622 $10.4 $16,869 Sale
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 4,514 $335.52 $1,514,524 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Option to sell Common Stock 8,917 $10.4 $92,737 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 8,917 $10.4 $92,737 Sale
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 4,456 $441.03 $1,965,212 Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Options to Purchase Common Stock 2,000 $10.4 $20,800 Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Common stock 2,000 $10.4 $20,800 Sale
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Common stock 2,000 $10.4 $20,800 Option
REGAN DANIEL PAUL officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 20,000 $37.69 $753,800 Sale
REGAN DANIEL PAUL officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 20,000 $434.69 $8,693,820 Option
REGAN DANIEL PAUL officer: Chief Commercial Officer officer: Chief Commercial Officer
Options to Purchase Common Stock 20,000 $37.69 $753,800 Sale
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 5,772 $367.3 $2,120,056 Sale
FUNDARO PAOLO director, 10 percent owner director, 10 percent owner
Common Stock 324 $367.51 $119,073 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 4,327 $10.4 $45,001 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Options to Purchase Common Stock 4,327 $10.4 $45,001 Option
FUNDARO PAOLO director, 10 percent owner director, 10 percent owner
Common Stock 6,922 $8.67 $59,993 Option
FUNDARO PAOLO director, 10 percent owner director, 10 percent owner
Options to Purchase Common Stock 3,461 $8.67 $29,996 Sale
FUNDARO PAOLO director, 10 percent owner director, 10 percent owner
Common Stock 6,922 $379.65 $2,627,910 Sale
TALLARIGO LORENZO director director
Common Stock 368 N/A N/A Sale
VEITINGER KLAUS R DR director director
Common Stock 162 $382.95 $62,038 Option
TALLARIGO LORENZO director director
Restricted Stock Units 368 N/A N/A Option
TALLARIGO LORENZO director director
Common Stock 368 N/A N/A Option
WILLIAMS NICOLE director director
Common Stock 368 N/A N/A Option
ORBIMED ADVISORS LLC director director
Common Stock, par value $0.001 per share 324 N/A N/A Option
SILVERSTEIN JONATHAN director director
Common Stock 324 N/A N/A Option
WILLIAMS NICOLE director director
Restricted Stock Units 368 N/A N/A Option
VEITINGER KLAUS R DR director director
Restricted Stock Units 324 N/A N/A Option
VEITINGER KLAUS R DR director director
Common Stock 324 N/A N/A Option
ORBIMED ADVISORS LLC director director
Restricted Stock Units 324 N/A N/A Option
SILVERSTEIN JONATHAN director director
Restricted Stock Units 324 N/A N/A Option
FUNDARO PAOLO director, 10 percent owner director, 10 percent owner
Common stock 324 N/A N/A Option
FUNDARO PAOLO director, 10 percent owner director, 10 percent owner
Restricted Stock Units 324 N/A N/A Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Options to Purchase Common Stock 2,000 $10.4 $20,800 Sale
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Common stock 2,000 $307.29 $614,574 Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Common stock 2,000 $10.4 $20,800 Option
PRUZANSKI MARK director director
Options to Purchase Common Stock 10,000 $8.67 $86,670 Option
AKKARAJU SRINIVAS director director
Options to Purchase Common Stock 2,500 $21.5 $53,750