Option
PRUZANSKI MARK director director
Common stock 200 $9.82 $1,964 Sale
PRUZANSKI MARK director director
Common stock 200 $9.82 $1,964 Sale
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Common stock 2,000 $37.06 $74,120 Option
PRUZANSKI MARK director director
Common stock 16,000 $38.35 $613,600 Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Options to Purchase Common Stock 2,000 $10.4 $20,800 Sale
PRUZANSKI MARK director director
Common stock 16,000 $38.35 $613,600 Option
PRUZANSKI MARK director director
Options to Purchase Common Stock 16,000 $38.35 $613,600 Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Common stock 2,000 $10.4 $20,800 Option
PRUZANSKI MARK director director
Common stock 9,000 $9.82 $88,398 Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Options to Purchase Common Stock 50,575 $9.25 $467,566 Sale
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common stock 50,575 $34.5 $1,744,838 Sale
PRUZANSKI MARK director director
Common stock 9,000 $9.82 $88,398 Option
PRUZANSKI MARK director director
Options to Purchase Common Stock 9,000 $9.82 $88,398 Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common stock 50,575 $9.25 $467,566 Sale
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 5,016 $32.7 $164,023 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Options to Purchase Common Stock 3,750 $10.4 $39,000 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,750 $10.4 $39,000 Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common stock 4,915 $34.5 $169,568 Sale
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common stock 4,915 $34.5 $169,568 Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Options to Purchase Common Stock 4,915 $34.5 $169,568 Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Options to Purchase Common Stock 1,200 $34.5 $41,400 Sale
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common stock 1,200 $34.5 $41,400 Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common stock 1,200 $34.5 $41,400 Sale
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common stock 110 $8.67 $953 Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common stock 110 $8.67 $953 Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Options to Purchase Common Stock 110 $8.67 $953 Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common stock 28,200 $15.08 $425,341 Sale
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common stock 28,200 $34.5 $972,900 Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Options to Purchase Common Stock 28,200 $15.08 $425,341 Sale
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 1,762 $31.25 $55,059 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 496 $10.4 $5,158 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Options to Purchase Common Stock 496 $10.4 $5,158 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Options to Purchase Common Stock 3,254 $10.4 $33,842 Sale
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 3,254 $31.29 $101,805 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 3,254 $10.4 $33,842 Option
VEITINGER KLAUS R DR director director
Common Stock 324 $31.9 $10,336 Option
ORBIMED ADVISORS LLC director director
Restricted Stock Units 649 N/A N/A Option
FUNDARO PAOLO director, 10 percent owner director, 10 percent owner
Common Stock 324 $31.9 $10,336 Option
WILLIAMS NICOLE director director
Restricted Stock Units 368 $31.9 $11,739 Option
WILLIAMS NICOLE director director
Common Stock 368 $31.9 $11,739 Option
FUNDARO PAOLO director, 10 percent owner director, 10 percent owner
Restricted Stock Units 324 $31.9 $10,336 Option
SILVERSTEIN JONATHAN director director
Common Stock 324 $31.9 $10,336 Option
VEITINGER KLAUS R DR director director
Restricted Stock Units 324 $31.9 $10,336 Option
ORBIMED ADVISORS LLC director director
Common Stock, par value $0.001 per share 324 N/A N/A Option
SILVERSTEIN JONATHAN director director
Restricted Stock Units 324 $31.9 $10,336 Option
ORBIMED ADVISORS LLC director director
Restricted Stock Units 1,330 N/A N/A Option
AKKARAJU SRINIVAS director director
Common stock 324 N/A N/A Option
AKKARAJU SRINIVAS director director
Restricted Stock Units 324 N/A N/A Sale
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 3,750 $34.33 $128,738 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 11,863 $10.4 $123,375