Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Option to Purchase Common Stock 3,500 $8.67 $30,335 Option
VEITINGER KLAUS R DR director director
Common Stock 1,000 $21.5 $21,500 Sale
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,500 $8.67 $30,335 Sale
MCMINN RACHEL officer: Chief Strategy Officer officer: Chief Strategy Officer
Common Stock 125 $160.24 $20,029 Option
AKKARAJU SRINIVAS director director
Common Stock 1,250 $21.5 $26,875 Option
AKKARAJU SRINIVAS director director
Options to Purchase Common Stock 1,250 $21.5 $26,875 Option
WILLIAMS NICOLE director director
Options to Purchase Common Stock 974 $9.82 $9,567 Option
WILLIAMS NICOLE director director
Common Stock 974 $9.82 $9,567 Sale
WILLIAMS NICOLE director director
Common Stock 974 $9.82 $9,567 Sale
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 858 $159.04 $136,455 Sale
PRUZANSKI MARK director director
Common Stock 167 $159.04 $26,560 Sale
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common Stock 54 $159.04 $8,588 Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Common Stock 649 N/A N/A Option
PRUZANSKI MARK director director
Common Stock 4,867 N/A N/A Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Restricted Stock Unit 1,622 N/A N/A Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Restricted Stock Units 649 N/A N/A Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common Stock 2,298 $81.7 $187,735 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 1,622 N/A N/A Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Option to Purchase Common Stock 1,000 $163.39 $163,390 Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Restricted Stock Units 1,298 N/A N/A Option
PRUZANSKI MARK director director
Restricted Stock Unit 4,867 N/A N/A Sale
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 282 $163.39 $46,076 Sale
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common Stock 1,000 $163.39 $163,390 Option
WILLIAMS NICOLE director director
Options to Purchase Common Stock 973 $9.82 $9,557 Option
WILLIAMS NICOLE director director
Common Stock 973 $9.82 $9,557 Sale
WILLIAMS NICOLE director director
Common Stock 973 $9.82 $9,557 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Option to Purchase Common Stock 8,794 $8.67 $76,218 Sale
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,500 $191.65 $670,761 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 8,794 $8.67 $76,218 Option
VEITINGER KLAUS R DR director director
Options to Purchase Common Stock 500 $21.5 $10,750 Sale
VEITINGER KLAUS R DR director director
Common Stock 500 $21.5 $10,750 Option
VEITINGER KLAUS R DR director director
Common Stock 500 $21.5 $10,750 Option
WILLIAMS NICOLE director director
Options to Purchase Common Stock 974 $9.82 $9,567 Sale
WILLIAMS NICOLE director director
Common Stock 974 $206.85 $201,472 Option
WILLIAMS NICOLE director director
Common Stock 974 $9.82 $9,567 Sale
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 4,272 $209.37 $894,429 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Option to Purchase Common Stock 3,500 $8.67 $30,335 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,500 $8.67 $30,335 Sale
VEITINGER KLAUS R DR director director
Common Stock 500 $21.5 $10,750 Option
VEITINGER KLAUS R DR director director
Options to Purchase Common Stock 500 $21.5 $10,750 Option
VEITINGER KLAUS R DR director director
Common Stock 500 $21.5 $10,750 Sale
MCMINN RACHEL officer: Chief Strategy Officer officer: Chief Strategy Officer
Common Stock 127 $262.09 $33,286 Sale
FUNDARO PAOLO director, 10 percent owner director, 10 percent owner
Common Stock 582 $285 $165,870 Sale
WILLIAMS NICOLE director director
Common Stock 973 $9.82 $9,557 Option
WILLIAMS NICOLE director director
Common Stock 973 $9.82 $9,557 Option
WILLIAMS NICOLE director director
Options to Purchase Common Stock 973 $9.82 $9,557 Option
PRUZANSKI MARK director director
Common Stock 12,500 $8.67 $108,338 Sale
PRUZANSKI MARK director director
Common Stock 12,500 $8.67 $108,338 Option
PRUZANSKI MARK director director
Options to Purchase Common Stock 12,500 $8.67 $108,338 Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Common Stock 4,067 $15.08 $61,343