Sale
AKKARAJU SRINIVAS director director
Common stock 3,250 $267.94 $870,805 Option
AKKARAJU SRINIVAS director director
Common stock 2,825 $21.5 $60,738 Sale
PRUZANSKI MARK director director
Common stock 10,000 $8.67 $86,670 Option
AKKARAJU SRINIVAS director director
Restricted Stock Units 325 $21.5 $6,988 Option
PRUZANSKI MARK director director
Common stock 10,000 $8.67 $86,670 Sale
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common stock 5,625 $269.71 $1,517,124 Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common stock 5,625 $31.9 $179,438 Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Options to Purchase Common Stock 5,625 $31.9 $179,438 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 8,968 $9.53 $85,492 Sale
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 4,928 $72.32 $356,413 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Options to Purchase Common Stock 8,968 $9.53 $85,492 Sale
TALLARIGO LORENZO director director
Common Stock 1,839 $67.41 $123,967 Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Options to Purchase Common Stock 1,634 $10.4 $16,994 Sale
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Common stock 1,634 $10.4 $16,994 Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Common stock 1,634 $10.4 $16,994 Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Common stock 1,298 N/A N/A Option
PRUZANSKI MARK director director
Common stock 4,868 N/A N/A Option
PRUZANSKI MARK director director
Restricted Stock Units 4,868 N/A N/A Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Restricted Stock Units 649 N/A N/A Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Restricted Stock Units 1,623 N/A N/A Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 1,623 N/A N/A Option
DUNCAN BARBARA GAYLE officer: Chief Accounting Officer officer: Chief Accounting Officer
Restricted Stock Units 1,298 N/A N/A Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Common stock 649 N/A N/A Option
PRUZANSKI MARK director director
Options to Purchase Common Stock 21,503 $2.89 $62,122 Option
PRUZANSKI MARK director director
Common stock 21,503 $2.89 $62,122 Sale
AKKARAJU SRINIVAS director director
Common stock 260 N/A N/A Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Options to Purchase Common Stock 3,750 $10.4 $39,000 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 3,750 $10.4 $39,000 Sale
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 5,016 $62.11 $311,549 Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Options to Purchase Common Stock 2,000 $10.4 $20,800 Sale
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Common stock 2,000 $50.88 $101,754 Option
ADORINI LUCIANO officer: See Remarks officer: See Remarks
Common stock 2,000 $10.4 $20,800 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Options to Purchase Common Stock 3,750 $10.4 $39,000 Sale
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 4,730 $48.08 $227,414 Option
SHAPIRO DAVID officer: Chief Medical Officer officer: Chief Medical Officer
Common stock 3,750 $10.4 $39,000 Sale
VEITINGER KLAUS R DR director director
Common Stock 162 $48.91 $7,923 Option
TALLARIGO LORENZO director director
Restricted Stock Units 368 N/A N/A Option
WILLIAMS NICOLE director director
Common Stock 368 N/A N/A Option
WILLIAMS NICOLE director director
Restricted Stock Units 368 N/A N/A Option
SILVERSTEIN JONATHAN director director
Common Stock 325 N/A N/A Option
FUNDARO PAOLO director, 10 percent owner director, 10 percent owner
Restricted Stock Units 325 N/A N/A Option
FUNDARO PAOLO director, 10 percent owner director, 10 percent owner
Common stock 325 N/A N/A Option
SILVERSTEIN JONATHAN director director
Restricted Stock Units 325 N/A N/A Option
ORBIMED ADVISORS LLC director director
Common Stock, par value $0.001 per share 325 N/A N/A Option
ORBIMED ADVISORS LLC director director
Restricted Stock Units 325 N/A N/A Option
VEITINGER KLAUS R DR director director
Common Stock 325 N/A N/A Option
TALLARIGO LORENZO director director
Common Stock 368 N/A N/A Option
VEITINGER KLAUS R DR director director
Restricted Stock Units 325 N/A N/A Sale
MICHELI FRANCESCO 10 percent owner 10 percent owner
Common Stock, par value $0.001 per share 124,912 $62.5 $7,807,000 Sale
ORBIMED ADVISORS LLC director director
Common Stock, par value $0.001 per share 40,088 $62.5 $2,505,500