Option
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (right to buy) 3,500 $4.3 $15,050 Sale
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 1,518 $36.27 $55,058 Sale
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 1,982 $35.52 $70,401 Option
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,500 $4.3 $15,050 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 4,412 $36.21 $159,759 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 10,088 $35.45 $357,620 Option
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (Right to Buy) 3,500 $4.3 $15,050 Sale
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,500 $39.42 $137,953 Option
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,500 $4.3 $15,050 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 30,347 $42.03 $1,275,484 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 18,135 $42.03 $762,214 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 18,135 $42.03 $762,214 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 215,122 $44.26 $9,521,300 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 128,550 $44.26 $5,689,623 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 128,550 $44.26 $5,689,623 Sale
BOXER CAPITAL, LLC director, 10 percent owner director, 10 percent owner
Common Stock 184,677 $43.78 $8,085,159 Sale
BOXER CAPITAL, LLC director, 10 percent owner director, 10 percent owner
Common Stock 515,323 $49.22 $25,361,621 Option
BINISZKIEWICZ DETLEV director director
Stock Option (Right to Buy) 3,500 $19 $66,500 Sale
BINISZKIEWICZ DETLEV director director
Common Stock 3,500 $51.9 $181,650 Option
BINISZKIEWICZ DETLEV director director
Common Stock 3,500 $19 $66,500 Option
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (Right to Buy) 7,000 $4.3 $30,100 Sale
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 7,000 $51.9 $363,300 Option
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 7,000 $4.3 $30,100 Sale
GALL MATTHEW officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 5,000 $46.45 $232,250 Option
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Stock Option (Right to Buy) 30,000 $4.3 $129,000 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 16,163 $44.81 $724,183 Option
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 1,663 $4.3 $7,151 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 19,226 $44.61 $857,576 Option
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 19,226 $4.3 $82,672 Option
HALLAL DAVID director director
Stock Option (Right to Buy) 50,000 $3.63 $181,250 Sale
HALLAL DAVID director director
Common Stock 50,000 $43.57 $2,178,500 Option
HALLAL DAVID director director
Common Stock 50,000 $3.63 $181,250 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 9,111 $43.94 $400,337 Option
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 9,111 $4.3 $39,177 Sale
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 7,000 $41 $287,000 Option
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (right to buy) 7,000 $4.3 $30,100 Option
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 7,000 $4.3 $30,100 Option
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (right to buy) 3,500 $4.3 $15,050 Sale
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,500 $34.5 $120,750 Option
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,500 $4.3 $15,050 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 19,456 $33.63 $654,305 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 32,558 $33.63 $1,094,926 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 19,456 $33.63 $654,305 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 10,208 $33.76 $344,622 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 17,083 $33.76 $576,722 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 10,208 $33.76 $344,622 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 20,167 $35.46 $715,122 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 33,749 $35.46 $1,196,740 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 20,167 $35.46 $715,122 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 37,187 $34.29 $1,274,956