Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 62,230 $34.29 $2,133,556 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 37,187 $34.29 $1,274,956 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 12,395 $34.59 $428,743 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 20,742 $34.59 $717,466 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 12,395 $34.59 $428,743 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 33,937 $34.91 $1,184,571 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 56,801 $34.91 $1,982,639 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 33,937 $34.91 $1,184,571 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 10,371 $34.92 $362,103 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 10,371 $34.92 $362,103 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 17,356 $34.92 $605,985 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 12,674 $35.76 $453,222 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 12,674 $35.76 $453,222 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 21,210 $35.76 $758,470 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 60,808 $36.09 $2,194,561 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 36,337 $36.09 $1,311,402 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 36,337 $36.09 $1,311,402 Option
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Stock Option (right to buy) 16,263 $12.45 $202,474 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 14,500 $36.08 $523,160 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 33,476 $36.36 $1,217,020 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 20,004 $36.36 $727,245 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 20,004 $36.36 $727,245 Option
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 16,263 $12.45 $202,474 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 35,333 $37.49 $1,324,458 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 21,114 $37.49 $791,458 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 21,114 $37.49 $791,458 Option
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (right to buy) 28,000 $4.3 $120,400 Sale
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 28,000 $34.5 $966,000 Option
LAGER JOANNE JENKINS officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 28,000 $4.3 $120,400 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 6,085 $28.89 $175,777 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 14,391 $28.42 $408,920 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 81 $28 $2,268 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 196 $28 $5,488 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 201 $28 $5,628 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 6,167 $27.14 $167,372 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 10,320 $27.14 $280,085 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 6,167 $27.14 $167,372 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 10,932 $27.77 $303,582 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 18,295 $27.77 $508,052 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 10,932 $27.77 $303,582 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 45,719 $27.3 $1,248,129 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 27,320 $27.3 $745,836 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 27,320 $27.3 $745,836 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 35,023 $27.13 $950,174 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 20,929 $27.13 $567,804 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 20,929 $27.13 $567,804 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 14,260 $27.09 $386,303 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 8,521 $27.09 $230,834 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 8,521 $27.09 $230,834 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 81,684 $27.24 $2,225,072