Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 48,812 $27.24 $1,329,639 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 48,812 $27.24 $1,329,639 Option
GALL MATTHEW officer: Chief Financial Officer officer: Chief Financial Officer
Stock Option (right to buy) 14,429 $6.16 $88,883 Option
GALL MATTHEW officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 14,429 $6.16 $88,883 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 3,400 $27.01 $91,834 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 2,032 $27.01 $54,884 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 2,032 $27.01 $54,884 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 1,922 $27 $51,894 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 1,149 $27 $31,023 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 1,149 $27 $31,023 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 34,659 $27.06 $937,873 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 20,711 $27.06 $560,440 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 20,711 $27.06 $560,440 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 11,471 $27 $309,717 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 6,855 $27 $185,085 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 6,855 $27 $185,085 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 3,836 $27 $103,572 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 2,292 $27 $61,884 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 2,292 $27 $61,884 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 32,154 $27 $868,158 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 19,214 $27 $518,778 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 19,214 $27 $518,778 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 19,455 $27.09 $527,036 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 11,625 $27.09 $314,921 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 11,625 $27.09 $314,921 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 1,089 $28.02 $30,512 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 8,221 $27.81 $228,626 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 4,913 $27.81 $136,631 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 4,913 $27.81 $136,631 Sale
DETHEUX MICHEL officer: Chief Executive Officer officer: Chief Executive Officer
Common Stock 5,322 $28.16 $149,862 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 61,800 $28.17 $1,740,906 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 36,930 $28.17 $1,040,318 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 36,930 $28.17 $1,040,318 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 23,921 $27.54 $658,784 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 14,294 $27.54 $393,657 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 14,294 $27.54 $393,657 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 32,858 $27.47 $902,609 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 19,635 $27.47 $539,373 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 19,635 $27.47 $539,373 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 40,673 $27.44 $1,115,864 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 24,303 $27.44 $666,753 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 24,303 $27.44 $666,753 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 76,473 $28.82 $2,203,952 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 45,698 $28.82 $1,317,016 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 45,698 $28.82 $1,317,016 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 35,565 $28.47 $1,012,536 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 21,253 $28.47 $605,073 Sale
MPM BIOVENTURES 2014, L.P. 10 percent owner 10 percent owner
Common Stock 21,253 $28.47 $605,073 Sale
GADICKE ANSBERT 10 percent owner 10 percent owner
Common Stock 40,336 $27.97 $1,128,198 Sale
MPM BIOVENTURES 2018, L.P. 10 percent owner 10 percent owner
Common Stock 24,104 $27.97 $674,189