Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,000,000 N/A N/A Purchase
FOLETTA MARK G director director
Common Stock 10,000 N/A N/A Option
PAPADOPOULOS STELIOS director director
Stock Option (Right to Buy) 33,177 N/A N/A Option
PAPADOPOULOS STELIOS director director
Common Stock 50,677 N/A N/A Purchase
RASTETTER WILLIAM H director director
Common Stock 61,235 N/A N/A Purchase
RASTETTER WILLIAM H director director
Common Stock 38,765 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 111,000 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 167,000 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 65,133 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 13,248 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Stock Option (Right to Buy) 60,000 N/A N/A Sale
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 60,000 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 60,000 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Stock Option (Right to Buy) 66,071 N/A N/A Sale
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 66,071 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 66,071 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Stock Option (Right to Buy) 73,929 N/A N/A Sale
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 73,929 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 73,929 N/A N/A Option
CARTER BRUCE L A director director
Stock Option (Right to Buy) 20,000 N/A N/A Sale
CARTER BRUCE L A director director
Common Stock 20,000 N/A N/A Option
CARTER BRUCE L A director director
Common Stock 20,000 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Stock Option (Right to Buy) 89,230 N/A N/A Sale
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 89,230 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 89,230 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Stock Option (Right to Buy) 70 N/A N/A Sale
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 70 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 70 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Stock Option (Right to Buy) 2,400 N/A N/A Sale
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 2,400 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 2,400 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Stock Option (Right to Buy) 3,300 N/A N/A Sale
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 3,300 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 3,300 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Stock Option (Right to Buy) 60,000 N/A N/A Sale
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 60,000 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 60,000 N/A N/A Sale
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 80,000 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Stock Option (Right to Buy) 85,000 N/A N/A Sale
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 85,000 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 85,000 N/A N/A Option
PAPADOPOULOS STELIOS director director
Stock Option (Right to Buy) 150,000 N/A N/A Option
PAPADOPOULOS STELIOS director director
Common Stock 150,000 N/A N/A Option
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 2,500 N/A N/A Sale
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,500 N/A N/A Option
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,500 N/A N/A Sale
ASTRAZENECA PLC 10 percent owner 10 percent owner
COMMON STOCK 2,000,000 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,279,411 N/A N/A Option
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 2,500 N/A N/A Sale
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,500 N/A N/A