Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 2,600 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 3,150 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 3,150 N/A N/A Sale
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 3,505 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Stock Option (Right to Buy) 3,505 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 3,505 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 2,600 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 2,600 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,750 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,750 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,000 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,000 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,700 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,700 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,850 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,850 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,700 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,700 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 5,000 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 5,000 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 5,000 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 5,000 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 3,500 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 3,500 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,750 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,750 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 4,500 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 4,500 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,800 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,800 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,200 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,200 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 3,100 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 3,100 N/A N/A Sale
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 3,505 N/A N/A Option
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 2,500 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 3,505 N/A N/A Sale
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,500 N/A N/A Option
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,500 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Stock Option (Right to Buy) 3,505 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 3,150 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 3,150 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,700 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,700 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 2,750 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 2,750 N/A N/A Sale
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 5,000 N/A N/A Option
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 5,000 N/A N/A Option
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 5,000 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Stock Option (Right to Buy) 3,505 N/A N/A