Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 3,750 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 3,750 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 4,100 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 4,100 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,500 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,500 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 2,100 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 2,100 N/A N/A Option
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,200 N/A N/A Sale
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,200 N/A N/A Option
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 2,200 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 3,500 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 3,500 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 3,400 N/A N/A Option
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Stock Option (Right to Buy) 2,000 N/A N/A Option
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,000 N/A N/A Sale
GIBSON NEIL W officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 2,000 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 3,400 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 2,000 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 2,000 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 2,400 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 2,400 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 6,000 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 6,000 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,650 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,650 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,500 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,500 N/A N/A Sale
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 3,505 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Common Stock 3,505 N/A N/A Option
XANTHOPOULOS KLEANTHIS G director, officer: President and .. director, officer: President an..
Stock Option (Right to Buy) 3,505 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 2,000 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 2,000 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,500 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,500 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 5,250 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 5,250 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 2,500 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 2,500 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 3,000 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 3,000 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,450 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,450 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,750 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,750 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 2,250 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 2,250 N/A N/A Sale
ISIS PHARMACEUTICALS INC 10 percent owner 10 percent owner
Common Stock 1,850 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 1,850 N/A N/A Sale
ALNYLAM PHARMACEUTICALS, INC. 10 percent owner 10 percent owner
Common Stock 2,600 N/A N/A