| Utility: Polynucleotide agents targeting hydroxyacid oxidase (glycolate oxidase, HAO1) and methods of use thereof Filling date: 8 Sep 2025 Issue date: 16 Mar 2021 | 14 Dec 2017 | 16 Mar 2021 |
| Utility: Serpina1 siRNAs: compositions of matter and methods of treatment Filling date: 8 Sep 2025 Issue date: 2 Mar 2021 | 17 Jul 2019 | 2 Mar 2021 |
| Utility: Factor XII (hageman factor) (F12), kallikrein B, plasma (fletcher factor) 1 (KLKB1), and kininogen 1 (KNG1) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 2 Mar 2021 | 24 May 2019 | 2 Mar 2021 |
| Utility: Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 2 Mar 2021 | 14 May 2019 | 2 Mar 2021 |
| Utility: Myostatin iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 2 Mar 2021 | 20 Sep 2017 | 2 Mar 2021 |
| Utility: ANGIOTENSINOGEN (AGT) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 18 Feb 2021 | 15 Sep 2020 | 18 Feb 2021 |
| Utility: Serpina1 iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 16 Feb 2021 | 14 Jun 2018 | 16 Feb 2021 |
| Utility: SERPINA1 SIRNAS: COMPOSITIONS OF MATTER AND METHODS OF TREATMENT Filling date: 8 Sep 2025 Issue date: 11 Feb 2021 | 26 Oct 2020 | 11 Feb 2021 |
| Utility: TMPRSS6 iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 9 Feb 2021 | 15 Nov 2018 | 9 Feb 2021 |
| Utility: MODIFIED DOUBLE-STRANDED RNA AGENTS Filling date: 8 Sep 2025 Issue date: 21 Jan 2021 | 25 Nov 2019 | 21 Jan 2021 |
| Utility: Programmed cell death 1 ligand 1 (PD-L1) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 12 Jan 2021 | 22 Aug 2016 | 12 Jan 2021 |
| Utility: STEROL REGULATORY ELEMENT BINDING PROTEIN (SREBP) CHAPERONE (SCAP) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 7 Jan 2021 | 27 Jul 2020 | 7 Jan 2021 |
| Utility: Polynucleotide agents targeting factor XII (hageman factor) (F12) and methods of use thereof Filling date: 8 Sep 2025 Issue date: 5 Jan 2021 | 6 Jan 2017 | 5 Jan 2021 |
| Utility: TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 17 Dec 2020 | 18 Aug 2020 | 17 Dec 2020 |
| Utility: POLYNUCLEOTIDE AGENTS TARGETING ANGIOTENSINOGEN (AGT) AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 10 Dec 2020 | 20 Aug 2020 | 10 Dec 2020 |
| Utility: KISSPEPTIN 1 (KISS1) IRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 10 Dec 2020 | 15 Nov 2018 | 10 Dec 2020 |
| Utility: TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES Filling date: 8 Sep 2025 Issue date: 3 Dec 2020 | 1 May 2020 | 3 Dec 2020 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MUTANT EGFR GENE Filling date: 8 Sep 2025 Issue date: 3 Dec 2020 | 3 Mar 2020 | 3 Dec 2020 |
| Utility: Methods and compositions for treating a proprotein convertase subtilisin kexin (PCSK9) gene-associated disorder Filling date: 8 Sep 2025 Issue date: 1 Dec 2020 | 16 Jan 2020 | 1 Dec 2020 |
| Utility: Glucokinase (GCK) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 24 Nov 2020 | 21 Dec 2017 | 24 Nov 2020 |
| Utility: MODIFIED RNAi AGENTS Filling date: 8 Sep 2025 Issue date: 12 Nov 2020 | 16 Apr 2020 | 12 Nov 2020 |
| Utility: TMPRSS6 iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 10 Nov 2020 | 7 Feb 2019 | 10 Nov 2020 |
| Utility: SERUM AMYLOID P COMPONENT (APCS) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 5 Nov 2020 | 19 May 2020 | 5 Nov 2020 |
| Utility: COMPLEMENT COMPONENT iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 29 Oct 2020 | 10 Jul 2020 | 29 Oct 2020 |
| Utility: AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENT COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 29 Oct 2020 | 9 Jul 2020 | 29 Oct 2020 |
| Utility: ASSAYS AND METHODS FOR DETERMINING EXPRESSION OF THE LECT2 GENE Filling date: 8 Sep 2025 Issue date: 29 Oct 2020 | 8 Nov 2018 | 29 Oct 2020 |
| Utility: Angiotensinogen (AGT) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 27 Oct 2020 | 13 Feb 2019 | 27 Oct 2020 |
| Utility: Dual Targeting siRNA Agents Filling date: 8 Sep 2025 Issue date: 22 Oct 2020 | 27 Feb 2020 | 22 Oct 2020 |
| Utility: Carbohydrate conjugates as delivery agents for oligonucleotides Filling date: 8 Sep 2025 Issue date: 20 Oct 2020 | 20 Nov 2018 | 20 Oct 2020 |
| Utility: Oligonucleotide-ligand conjugates and process for their preparation Filling date: 8 Sep 2025 Issue date: 20 Oct 2020 | 11 Jul 2014 | 20 Oct 2020 |
| Utility: RNAI AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING TRANSTHYRETIN (TTR) ASSOCIATED DISEASES Filling date: 8 Sep 2025 Issue date: 8 Oct 2020 | 9 Jan 2020 | 8 Oct 2020 |
| Utility: Compositions and Methods for Inhibiting Expression of the PCSK9 Gene Filling date: 8 Sep 2025 Issue date: 8 Oct 2020 | 5 Nov 2019 | 8 Oct 2020 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITION OF HAO1 (HYDROXYACID OXIDASE 1 (GLYCOLATE OXIDASE)) GENE EXPRESSION Filling date: 8 Sep 2025 Issue date: 8 Oct 2020 | 4 Nov 2019 | 8 Oct 2020 |
| Utility: HIGH MOBILITY GROUP BOX-1 (HMGB1) IRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 1 Oct 2020 | 18 Dec 2018 | 1 Oct 2020 |
| Utility: CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES Filling date: 8 Sep 2025 Issue date: 24 Sep 2020 | 29 Apr 2020 | 24 Sep 2020 |
| Utility: XANTHINE DEHYDROGENASE (XDH) IRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 24 Sep 2020 | 27 Jan 2020 | 24 Sep 2020 |
| Utility: METHODS AND COMPOSITIONS FOR DETECTING ANTI-DRUG ANTIBODIES Filling date: 8 Sep 2025 Issue date: 17 Sep 2020 | 28 Feb 2020 | 17 Sep 2020 |
| Utility: HEPATITIS D VIRUS (HDV) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 17 Sep 2020 | 26 Feb 2020 | 17 Sep 2020 |
| Utility: Compositions and Methods for Inhibiting Expression of Transthyretin Filling date: 8 Sep 2025 Issue date: 10 Sep 2020 | 23 Jan 2020 | 10 Sep 2020 |
| Utility: Sterol regulatory element binding protein (SREBP) chaperone (SCAP) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 8 Sep 2020 | 7 Jun 2018 | 8 Sep 2020 |
| Utility: INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN, ACID LABILE SUBUNIT (IGFALS) AND INSULIN-LIKE GROWTH FACTOR 1 (IGF-1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 3 Sep 2020 | 15 Oct 2019 | 3 Sep 2020 |
| Utility: Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes Filling date: 8 Sep 2025 Issue date: 20 Aug 2020 | 2 Dec 2019 | 20 Aug 2020 |
| Utility: COMPLEMENT COMPONENT iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 20 Aug 2020 | 18 Sep 2019 | 20 Aug 2020 |
| Utility: Compositions and methods for inhibiting expression of CD274/PD-L1 gene Filling date: 8 Sep 2025 Issue date: 18 Aug 2020 | 27 Feb 2018 | 18 Aug 2020 |
| Utility: Compositions and methods for inhibiting expression of the LECT2 gene Filling date: 8 Sep 2025 Issue date: 18 Aug 2020 | 8 Apr 2016 | 18 Aug 2020 |
| Utility: THERAPEUTIC COMPOSITIONS Filling date: 8 Sep 2025 Issue date: 13 Aug 2020 | 22 Apr 2020 | 13 Aug 2020 |
| Utility: POLYNUCLEOTIDE AGENTS TARGETING PATATIN-LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 (PNPLA3) AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 6 Aug 2020 | 14 Feb 2020 | 6 Aug 2020 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITIION OF EXPRESSION OF PROTEIN C (PROC) GENES Filling date: 8 Sep 2025 Issue date: 30 Jul 2020 | 11 Nov 2019 | 30 Jul 2020 |
| Utility: LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF SERUM AMYLOID A GENE Filling date: 8 Sep 2025 Issue date: 30 Jul 2020 | 3 Oct 2019 | 30 Jul 2020 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF FACTOR V Filling date: 8 Sep 2025 Issue date: 23 Jul 2020 | 4 Nov 2019 | 23 Jul 2020 |
