| Utility: ANGIOPOIETIN-LIKE 3 (ANGPTL3) IRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 16 Jul 2020 | 12 Dec 2019 | 16 Jul 2020 |
| Utility: Polynucleotide agents targeting angiotensinogen (AGT) and methods of use thereof Filling date: 8 Sep 2025 Issue date: 14 Jul 2020 | 25 May 2016 | 14 Jul 2020 |
| Utility: LACTATE DEHYDROGENASE A (LDHA) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 2 Jul 2020 | 6 Mar 2020 | 2 Jul 2020 |
| Utility: METHODS FOR TREATING OR PREVENTING CONTACT-ACTIVATION PATHWAY-ASSOCIATED DISEASES USING iRNA COMPOSITIONS TARGETING FACTOR XII (HAGEMAN FACTOR) (F12) Filling date: 8 Sep 2025 Issue date: 2 Jul 2020 | 6 Jul 2018 | 2 Jul 2020 |
| Utility: siRNA Therapy for Transthyretin (TTR) Related Ocular Amyloidosis Filling date: 8 Sep 2025 Issue date: 25 Jun 2020 | 9 Sep 2019 | 25 Jun 2020 |
| Utility: APOLIPOPROTEIN C3 (APOC3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 25 Jun 2020 | 7 Aug 2019 | 25 Jun 2020 |
| Utility: Serpina1 iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 16 Jun 2020 | 11 Nov 2019 | 16 Jun 2020 |
| Utility: Transthyretin (TTR) iRNA compositions and methods of use thereof for treating or preventing TTR-associated diseases Filling date: 8 Sep 2025 Issue date: 16 Jun 2020 | 18 Dec 2018 | 16 Jun 2020 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE Filling date: 8 Sep 2025 Issue date: 11 Jun 2020 | 17 Jul 2019 | 11 Jun 2020 |
| Utility: Modified iRNA agents Filling date: 8 Sep 2025 Issue date: 9 Jun 2020 | 27 Feb 2018 | 9 Jun 2020 |
| Utility: KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 4 Jun 2020 | 19 Jun 2019 | 4 Jun 2020 |
| Utility: Therapeutic compositions Filling date: 8 Sep 2025 Issue date: 2 Jun 2020 | 14 Mar 2019 | 2 Jun 2020 |
| Utility: Modified RNAi agents Filling date: 8 Sep 2025 Issue date: 2 Jun 2020 | 19 Oct 2018 | 2 Jun 2020 |
| Utility: Compositions and methods directed to treating liver fibrosis Filling date: 8 Sep 2025 Issue date: 2 Jun 2020 | 26 Feb 2018 | 2 Jun 2020 |
| Utility: Methods For Inhibition Of HAO1 (Hydroxyacid Oxidase 1 (Glycolate Oxidase)) Gene Expression Filling date: 8 Sep 2025 Issue date: 28 May 2020 | 12 Jul 2018 | 28 May 2020 |
| Utility: METHODS AND COMPOSITIONS FOR TREATING A PROPROTEIN CONVERTASE SUBTILISIN KEXIN (PCSK9) GENE-ASSOCIATED DISORDER Filling date: 8 Sep 2025 Issue date: 7 May 2020 | 16 Jan 2020 | 7 May 2020 |
| Utility: HEPATITIS B VIRUS (HBV) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 7 May 2020 | 4 Nov 2019 | 7 May 2020 |
| Utility: ANGIOPOIETIN-LIKE 3 (ANGPTL3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 7 May 2020 | 14 May 2019 | 7 May 2020 |
| Utility: MYOSTATIN IRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 7 May 2020 | 20 Sep 2017 | 7 May 2020 |
| Utility: Hepatitis D virus (HDV) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 5 May 2020 | 10 May 2017 | 5 May 2020 |
| Utility: FACTOR XII (HAGEMAN FACTOR) (F12), KALLIKREIN B, PLASMA (FLETCHER FACTOR) 1 (KLKB1), AND KININOGEN 1 (KNG1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 30 Apr 2020 | 24 May 2019 | 30 Apr 2020 |
| Utility: LACTATE DEHYDROGENASE A (LDHA) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 16 Apr 2020 | 17 Dec 2019 | 16 Apr 2020 |
| Utility: Modified double-stranded RNA agents Filling date: 8 Sep 2025 Issue date: 7 Apr 2020 | 15 Apr 2019 | 7 Apr 2020 |
| Utility: Modified double-stranded RNA agents Filling date: 8 Sep 2025 Issue date: 7 Apr 2020 | 11 Feb 2019 | 7 Apr 2020 |
| Utility: POLYNUCLEOTIDE AGENTS TARGETING COMPLEMENT COMPONENT C5 AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 26 Mar 2020 | 2 Jul 2019 | 26 Mar 2020 |
| Utility: Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (PNPLA3) and methods of use thereof Filling date: 8 Sep 2025 Issue date: 24 Mar 2020 | 12 Mar 2018 | 24 Mar 2020 |
| Utility: QUANTIFICATION OF TRANSTHYRETIN AND ITS ISOFORMS Filling date: 8 Sep 2025 Issue date: 19 Mar 2020 | 25 Apr 2019 | 19 Mar 2020 |
| Utility: APOLIPOPROTEIN C3 (APOC3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 12 Mar 2020 | 25 Nov 2019 | 12 Mar 2020 |
| Utility: SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 12 Mar 2020 | 11 Nov 2019 | 12 Mar 2020 |
| Utility: COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 5 Mar 2020 | 20 May 2019 | 5 Mar 2020 |
| Utility: Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 25 Feb 2020 | 12 Oct 2017 | 25 Feb 2020 |
| Utility: RNAi agents, compositions and methods of use thereof for treating transthyretin (TTR) associated diseases Filling date: 8 Sep 2025 Issue date: 25 Feb 2020 | 21 Jun 2016 | 25 Feb 2020 |
| Utility: Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 11 Feb 2020 | 18 Jun 2019 | 11 Feb 2020 |
| Utility: METHODS FOR THE TREATMENT OF SUBJECTS HAVING A HEPATITIS B VIRUS (HBV) INFECTION Filling date: 8 Sep 2025 Issue date: 6 Feb 2020 | 18 Apr 2018 | 6 Feb 2020 |
| Utility: Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 4 Feb 2020 | 18 Jun 2019 | 4 Feb 2020 |
| Utility: Monomers and oligonucleotides comprising cycloaddition adduct(s) Filling date: 8 Sep 2025 Issue date: 4 Feb 2020 | 30 Dec 2016 | 4 Feb 2020 |
| Utility: COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 30 Jan 2020 | 7 May 2019 | 30 Jan 2020 |
| Utility: COMPLEMENT COMPONENT C5 IRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 30 Jan 2020 | 9 Apr 2019 | 30 Jan 2020 |
| Utility: Hepatitis B virus (HBV) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 24 Dec 2019 | 10 May 2017 | 24 Dec 2019 |
| Utility: BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS Filling date: 8 Sep 2025 Issue date: 12 Dec 2019 | 23 Jul 2019 | 12 Dec 2019 |
| Utility: Compositions and methods for inhibiting expression of the PCSK9 gene Filling date: 8 Sep 2025 Issue date: 10 Dec 2019 | 8 Nov 2017 | 10 Dec 2019 |
| Utility: Compositions and methods for inhibiting expression of factor V Filling date: 8 Sep 2025 Issue date: 10 Dec 2019 | 14 Aug 2017 | 10 Dec 2019 |
| Utility: Insulin-like growth factor binding protein, acid labile subunit (IGFALS) compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 3 Dec 2019 | 8 Jul 2016 | 3 Dec 2019 |
| Utility: SERPINA1 SIRNAS: COMPOSITIONS OF MATTER AND METHODS OF TREATMENT Filling date: 8 Sep 2025 Issue date: 21 Nov 2019 | 17 Jul 2019 | 21 Nov 2019 |
| Utility: ANGIOPOIETIN-LIKE 3 (ANGPTL3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 21 Nov 2019 | 18 Jun 2019 | 21 Nov 2019 |
| Utility: METHODS FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES USING TRANSTHYRETIN (TTR) iRNA COMPOSITIONS Filling date: 8 Sep 2025 Issue date: 21 Nov 2019 | 15 Dec 2017 | 21 Nov 2019 |
| Utility: Compositions and methods for inhibition of HAO1 (Hydroxyacid Oxidase 1 (Glycolate Oxidase)) gene expression Filling date: 8 Sep 2025 Issue date: 19 Nov 2019 | 9 Oct 2015 | 19 Nov 2019 |
| Utility: MODIFIED iRNA AGENTS Filling date: 8 Sep 2025 Issue date: 14 Nov 2019 | 26 Jul 2019 | 14 Nov 2019 |
| Utility: TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES Filling date: 8 Sep 2025 Issue date: 14 Nov 2019 | 18 Dec 2018 | 14 Nov 2019 |
| Utility: Lipid formulated compositions and methods for inhibiting expression of Serum Amyloid A gene Filling date: 8 Sep 2025 Issue date: 12 Nov 2019 | 19 Dec 2017 | 12 Nov 2019 |
