| Utility: ANGIOTENSINOGEN (AGT) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 7 Oct 2021 | 7 Apr 2021 | 7 Oct 2021 |
| Utility: Ketohexokinase (KHK) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 5 Oct 2021 | 19 Jun 2019 | 5 Oct 2021 |
| Utility: Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 28 Sep 2021 | 26 Jan 2021 | 28 Sep 2021 |
| Utility: APOLIPOPROTEIN C3 (APOC3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 23 Sep 2021 | 22 Feb 2021 | 23 Sep 2021 |
| Utility: Compositions and methods for inhibition of expression of protein C (PROC) genes Filling date: 8 Sep 2025 Issue date: 14 Sep 2021 | 11 Nov 2019 | 14 Sep 2021 |
| Utility: Carbohydrate conjugates as delivery agents for oligonucleotides Filling date: 8 Sep 2025 Issue date: 7 Sep 2021 | 29 Apr 2020 | 7 Sep 2021 |
| Utility: SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 2 Sep 2021 | 8 Mar 2021 | 2 Sep 2021 |
| Utility: COMPLEMENT COMPONENT C3 IRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 26 Aug 2021 | 1 Nov 2018 | 26 Aug 2021 |
| Utility: iRNA AGENTS WITH BIOCLEAVABLE TETHERS Filling date: 8 Sep 2025 Issue date: 19 Aug 2021 | 28 Apr 2021 | 19 Aug 2021 |
| Utility: TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 19 Aug 2021 | 15 Dec 2020 | 19 Aug 2021 |
| Utility: Factor XII (Hageman Factor) (F12), KALLIKREIN B, PLASMA (FLETCHER FACTOR) 1 (KLKB1), and Kininogen 1 (KNG1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 12 Aug 2021 | 15 Dec 2020 | 12 Aug 2021 |
| Utility: MODIFIED RNA AGENTS WITH REDUCED OFF-TARGET EFFECT Filling date: 8 Sep 2025 Issue date: 5 Aug 2021 | 16 May 2019 | 5 Aug 2021 |
| Utility: COMPOSITIONS AND METHODS FOR IMPROVING STRAND BIASED Filling date: 8 Sep 2025 Issue date: 5 Aug 2021 | 7 May 2019 | 5 Aug 2021 |
| Utility: Methods of treating transthyretin (TTR) mediated amyloidosis Filling date: 8 Sep 2025 Issue date: 3 Aug 2021 | 3 Aug 2018 | 3 Aug 2021 |
| Utility: Biodegradable lipids for the delivery of active agents Filling date: 8 Sep 2025 Issue date: 27 Jul 2021 | 23 Jul 2019 | 27 Jul 2021 |
| Utility: POLYNUCLEOTIDE AGENTS TARGETING FACTOR XII (HAGEMAN FACTOR) (F12) AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 22 Jul 2021 | 24 Nov 2020 | 22 Jul 2021 |
| Utility: Insulin-like growth factor binding protein, acid labile subunit (IGFALS) and insulin-like growth factor 1 (IGF-1) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 20 Jul 2021 | 15 Oct 2019 | 20 Jul 2021 |
| Utility: Hepatitis B virus (HBV) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 13 Jul 2021 | 4 Nov 2019 | 13 Jul 2021 |
| Utility: CHIRALLY-ENRICHED DOUBLE-STRANDED RNA AGENTS Filling date: 8 Sep 2025 Issue date: 8 Jul 2021 | 21 Dec 2018 | 8 Jul 2021 |
| Utility: Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 6 Jul 2021 | 5 Feb 2019 | 6 Jul 2021 |
| Utility: Multi-targeted single entity conjugates Filling date: 8 Sep 2025 Issue date: 6 Jul 2021 | 15 Jul 2016 | 6 Jul 2021 |
| Utility: PATATIN-LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 (PNPLA3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 24 Jun 2021 | 23 Feb 2021 | 24 Jun 2021 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF FACTOR V Filling date: 8 Sep 2025 Issue date: 24 Jun 2021 | 23 Feb 2021 | 24 Jun 2021 |
| Utility: PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 24 Jun 2021 | 6 Nov 2020 | 24 Jun 2021 |
| Utility: COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 17 Jun 2021 | 14 Oct 2020 | 17 Jun 2021 |
| Utility: Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 15 Jun 2021 | 21 Dec 2020 | 15 Jun 2021 |
| Utility: Amyloid precursor protein (APP) RNAi agent compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 15 Jun 2021 | 9 Jul 2020 | 15 Jun 2021 |
| Utility: ANGIOPOIETIN-LIKE 3 (ANGPTL3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 10 Jun 2021 | 26 Jan 2021 | 10 Jun 2021 |
| Utility: ANGIOPOIETIN-LIKE 3 (ANGPTL3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 10 Jun 2021 | 5 Nov 2020 | 10 Jun 2021 |
| Utility: GLUCOKINASE (GCK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 10 Jun 2021 | 14 Oct 2020 | 10 Jun 2021 |
| Utility: COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) Filling date: 8 Sep 2025 Issue date: 10 Jun 2021 | 14 Oct 2020 | 10 Jun 2021 |
| Utility: POLYNUCLEOTIDE AGENTS TARGETING ANGIOTENSINOGEN (AGT) AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 10 Jun 2021 | 3 Jun 2020 | 10 Jun 2021 |
| Utility: Compositions and methods for inhibiting expression of the ALAS1 gene Filling date: 8 Sep 2025 Issue date: 8 Jun 2021 | 20 Sep 2018 | 8 Jun 2021 |
| Utility: TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 3 Jun 2021 | 5 Oct 2020 | 3 Jun 2021 |
| Utility: METHODS AND COMPOSITIONS FOR TREATING A PROPROTEIN CONVERTASE SUBTILISIN KEXIN (PCSK9) GENE-ASSOCIATED DISORDER Filling date: 8 Sep 2025 Issue date: 3 Jun 2021 | 15 Jul 2020 | 3 Jun 2021 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF CD274/PD-L1 GENE Filling date: 8 Sep 2025 Issue date: 27 May 2021 | 7 Jul 2020 | 27 May 2021 |
| Utility: Angiotensinogen (AGT) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 25 May 2021 | 10 Nov 2020 | 25 May 2021 |
| Utility: iRNA agents with biocleavable tethers Filling date: 8 Sep 2025 Issue date: 25 May 2021 | 23 Jul 2018 | 25 May 2021 |
| Utility: Serpina1 iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 4 May 2021 | 23 May 2019 | 4 May 2021 |
| Utility: TMPRSS6 iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 27 Apr 2021 | 18 Aug 2020 | 27 Apr 2021 |
| Utility: Conserved HBV and HCV sequences useful for gene silencing Filling date: 8 Sep 2025 Issue date: 20 Apr 2021 | 27 Apr 2018 | 20 Apr 2021 |
| Utility: Polynucleotide agents targeting programmed cell death 1 ligand 1 (PD-L1) and methods of use thereof Filling date: 8 Sep 2025 Issue date: 20 Apr 2021 | 9 Dec 2016 | 20 Apr 2021 |
| Utility: APOLIPOPROTEIN C3 (APOC3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 15 Apr 2021 | 21 Dec 2020 | 15 Apr 2021 |
| Utility: Polynucleotide agents targeting aminolevulinic acid synthase-1 (ALAS1) and uses thereof Filling date: 8 Sep 2025 Issue date: 6 Apr 2021 | 30 Mar 2017 | 6 Apr 2021 |
| Utility: ANGIOTENSINOGEN (AGT) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 1 Apr 2021 | 10 Nov 2020 | 1 Apr 2021 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE LECT2 GENE Filling date: 8 Sep 2025 Issue date: 1 Apr 2021 | 13 Jul 2020 | 1 Apr 2021 |
| Utility: OLIGONUCLEOTIDES COMPRISING ACYCLIC AND ABASIC NUCLEOSIDES AND ANALOGS Filling date: 8 Sep 2025 Issue date: 25 Mar 2021 | 3 Dec 2020 | 25 Mar 2021 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE Filling date: 8 Sep 2025 Issue date: 25 Mar 2021 | 4 Jun 2020 | 25 Mar 2021 |
| Utility: COMPOSITIONS AND METHODS DIRECTED TO TREATING LIVER FIBROSIS Filling date: 8 Sep 2025 Issue date: 25 Mar 2021 | 6 May 2020 | 25 Mar 2021 |
| Utility: GNAQ targeted dsRNA compositions and methods for inhibiting expression Filling date: 8 Sep 2025 Issue date: 23 Mar 2021 | 3 Apr 2018 | 23 Mar 2021 |
