Sale
HUBER REID M officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 8,577 $119.21 $1,022,464 Sale
TROWER PAUL officer: Principal Accounting Officer officer: Principal Accounting O..
Common Stock 3,000 $17.79 $53,370 Option
TROWER PAUL officer: Principal Accounting Officer officer: Principal Accounting O..
Non-Qualified Stock Option (right to buy) 3,000 $17.79 $53,370 Option
TROWER PAUL officer: Principal Accounting Officer officer: Principal Accounting O..
Common Stock 3,000 $17.79 $53,370 Option
FLANNELLY BARRY P officer: EVP & General Manager US officer: EVP & General Manager US
Common Stock 2,064 $48.44 $99,980 Option
FLANNELLY BARRY P officer: EVP & General Manager US officer: EVP & General Manager US
Incentive Stock Option (right to buy) 2,064 $48.44 $99,980 Option
SIEGEL ERIC H. officer: EVP, General Counsel officer: EVP, General Counsel
Non-Qualified Stock Option (right to buy) 1,820 $64.55 $117,481 Option
SIEGEL ERIC H. officer: EVP, General Counsel officer: EVP, General Counsel
Common Stock 1,820 $64.55 $117,481 Sale
FLANNELLY BARRY P officer: EVP & General Manager US officer: EVP & General Manager US
Common Stock 5,296 $124.68 $660,305 Sale
SIEGEL ERIC H. officer: EVP, General Counsel officer: EVP, General Counsel
Common Stock 1,820 $64.55 $117,481 Sale
GRYSKA DAVID W officer: Executive Vice President, CFO officer: Executive Vice Preside..
Common Stock 1,389 $67.06 $93,146 Purchase
BIENAIME JEAN JACQUES director director
Common Stock 500 $124.26 $62,130 Option
GRYSKA DAVID W officer: Executive Vice President, CFO officer: Executive Vice Preside..
Common Stock 1,389 $67.06 $93,146 Option
GRYSKA DAVID W officer: Executive Vice President, CFO officer: Executive Vice Preside..
Non-Qualified Stock Option (right to buy) 1,389 $67.06 $93,146 Option
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 60,000 $7.26 $435,600 Option
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Non-Qualified Stock Options (right 20,000 $7.26 $145,200 Purchase
BIENAIME JEAN JACQUES director director
Common Stock 1,000 N/A N/A Sale
GRYSKA DAVID W officer: Executive Vice President, CFO officer: Executive Vice Preside..
Common Stock 41,528 $102.53 $4,257,866 Option
SIEGEL ERIC H. officer: EVP, General Counsel officer: EVP, General Counsel
Non-Qualified Stock Option (right to buy) 4,043 $79.25 $320,408 Option
SIEGEL ERIC H. officer: EVP, General Counsel officer: EVP, General Counsel
Common Stock 4,043 $79.25 $320,408 Option
GRYSKA DAVID W officer: Executive Vice President, CFO officer: Executive Vice Preside..
Common Stock 41,528 $102.53 $4,257,866 Option
GRYSKA DAVID W officer: Executive Vice President, CFO officer: Executive Vice Preside..
Non-Qualified Stock Option (right to buy) 39,789 $138 $5,490,882 Option
GRYSKA DAVID W officer: Executive Vice President, CFO officer: Executive Vice Preside..
Incentive Stock Option (right to buy) 1,739 $67.06 $116,617 Sale
SIEGEL ERIC H. officer: EVP, General Counsel officer: EVP, General Counsel
Common Stock 4,043 $79.25 $320,408 Purchase
BIENAIME JEAN JACQUES director director
Common Stock 1,000 $139.48 $139,480 Option
STEIN STEVEN H officer: EVP & Chief Medical Officer officer: EVP & Chief Medical Of..
Non-Qualified Stock Option (right to buy) 32,000 $113.3 $3,625,440 Sale
STEIN STEVEN H officer: EVP & Chief Medical Officer officer: EVP & Chief Medical Of..
Common Stock 32,000 $113.3 $3,625,440 Option
STEIN STEVEN H officer: EVP & Chief Medical Officer officer: EVP & Chief Medical Of..
Common Stock 32,000 $113.3 $3,625,440 Option
FRIEDMAN PAUL A director director
Common Stock 41,693 $148.18 $6,178,069 Sale
BROOKE PAUL A director director
Common Stock 20,000 $7.26 $145,200 Option
FRIEDMAN PAUL A director director
Non-Qualified Stock Option (right to buy) 41,693 $148.18 $6,178,069 Sale
FRIEDMAN PAUL A director director
Common Stock 41,693 $148.18 $6,178,069 Option
BROOKE PAUL A director director
Common Stock 20,000 $7.26 $145,200 Option
BROOKE PAUL A director director
Non-Qualified Stock Option (right to buy) 20,000 $7.26 $145,200 Option
FRIEDMAN PAUL A director director
Common Stock 8,307 $18.32 $152,184 Option
FRIEDMAN PAUL A director director
Non-Qualified Stock Option (right to buy) 8,307 $18.32 $152,184 Sale
FRIEDMAN PAUL A director director
Common Stock 8,307 $151.45 $1,258,095 Sale
HUBER REID M officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 2,008 $131.88 $264,815 Option
FRIEDMAN PAUL A director director
Common Stock 50,000 $18.32 $916,000 Option
FRIEDMAN PAUL A director director
Non-Qualified Stock Option (right to buy) 50,000 $18.32 $916,000 Sale
FRIEDMAN PAUL A director director
Common Stock 50,000 $18.32 $916,000 Sale
HUBER REID M officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 11,739 $113.55 $1,332,963 Sale
SWAIN PAULA J officer: EVP, Human Resources officer: EVP, Human Resources
Common Stock 10,000 $103.26 $1,032,600 Option
SWAIN PAULA J officer: EVP, Human Resources officer: EVP, Human Resources
Common Stock 10,000 $14.72 $147,200 Option
SWAIN PAULA J officer: EVP, Human Resources officer: EVP, Human Resources
Non-Qualified Stock Option (right to buy) 7,683 $14.72 $113,094 Sale
HUBER REID M officer: EVP, Chief Scientific Officer officer: EVP, Chief Scientific ..
Common Stock 2,715 $109.95 $298,514 Sale
SWAIN PAULA J officer: EVP, Human Resources officer: EVP, Human Resources
Common Stock 10,000 $14.72 $147,200 Option
SWAIN PAULA J officer: EVP, Human Resources officer: EVP, Human Resources
Common Stock 10,000 $14.72 $147,200 Option
SWAIN PAULA J officer: EVP, Human Resources officer: EVP, Human Resources
Non-Qualified Stock Option (right to buy) 10,000 $14.72 $147,200 Option
FLANNELLY BARRY P officer: EVP & General Manager US officer: EVP & General Manager US
Common Stock 24,204 $48.44 $1,172,442