Sale
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 3,820 $14.86 $56,769 Sale
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 179,644 $14.86 $2,669,689 Sale
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 5,722 $14.86 $85,035 Sale
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 227,071 $14.71 $3,340,669 Sale
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 4,829 $14.71 $71,044 Sale
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 88,670 $14.71 $1,304,513 Sale
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 7,180 $14.71 $105,632 Sale
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 7,233 $14.71 $106,412 Sale
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 19,433 $14.94 $290,387 Sale
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 19,291 $14.94 $288,265 Sale
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 238,230 $14.94 $3,559,871 Sale
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 12,974 $14.94 $193,870 Sale
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 610,072 $14.94 $9,116,306 Sale
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 2,812 $14 $39,365 Sale
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 1,877 $14 $26,276 Sale
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 88,250 $14 $1,235,412 Sale
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 34,462 $14 $482,434 Sale
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 2,789 $14 $39,043 Sale
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 9,916 $14.08 $139,657 Sale
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 122,467 $14.08 $1,724,825 Sale
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 9,991 $14.08 $140,713 Sale
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 6,670 $14.08 $93,940 Sale
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 313,622 $14.08 $4,417,052 Sale
CHARDONNET LAURENT other: Vice President and Treasurer other: Vice President and Treas..
Common Stock 15,618 $14.07 $219,667 Option
SCHRECK PATRICIA A officer: EVP, General Counsel officer: EVP, General Counsel
Common Stock 94,960 $6.15 $584,004 Sale
SCHRECK PATRICIA A officer: EVP, General Counsel officer: EVP, General Counsel
Common Stock 94,960 $13.86 $1,316,146 Option
SCHRECK PATRICIA A officer: EVP, General Counsel officer: EVP, General Counsel
Non-Qualified Stock Options 94,960 $6.15 $584,004 Option
FRIEDMAN PAUL A director director
Incentive Stock Option (right to buy) 14,247 $5.46 $77,789 Option
FRIEDMAN PAUL A director director
Common Stock 25,142 $6.28 $157,766 Purchase
FRIEDMAN PAUL A director director
Common Stock 10,000 $10.43 $104,250 Purchase
HASTINGS DAVID C officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 2,000 $10.24 $20,480 Option
SWAIN PAULA J officer: EVP, Human Resources officer: EVP, Human Resources
Common Stock 97,917 $6.12 $599,252 Option
SWAIN PAULA J officer: EVP, Human Resources officer: EVP, Human Resources
Non Qualified Stock Options 25,000 $6.27 $156,750 Sale
SWAIN PAULA J officer: EVP, Human Resources officer: EVP, Human Resources
Common Stock 97,917 $13.15 $1,287,609 Option
LEVY RICHARD S officer: EVP, Chief Drug Dev Officer officer: EVP, Chief Drug Dev Of..
Incentive Stock Options 20,000 $4.19 $83,800 Sale
LEVY RICHARD S officer: EVP, Chief Drug Dev Officer officer: EVP, Chief Drug Dev Of..
Common Stock 20,000 $4.19 $83,800 Option
LEVY RICHARD S officer: EVP, Chief Drug Dev Officer officer: EVP, Chief Drug Dev Of..
Common Stock 20,000 $4.19 $83,800 Sale
FRIEDMAN STEVEN M. officer: EVP, Biology & Preclinical Dev officer: EVP, Biology & Preclin..
Common Stock 22,000 $10.9 $239,800 Purchase
FRIEDMAN PAUL A director director
Common Stock 9,400 $2.1 $19,740 Purchase
FRIEDMAN PAUL A director director
Common Stock 10,600 $2.1 $22,260 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 1,248 $2.16 $2,693 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Senior Convertible Note due 2011 2,000 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 11,232 $2.16 $24,239 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 312 $2.16 $673 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5 % Senior Convertible Note due 2011 485,000 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 97,000 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5 % Subordinated Convertible Note due 2011 388,000 N/A N/A Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 5 $2.16 $11 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
3.5% Senior Convertible Note due 2011 4,367,000 N/A N/A Purchase
FRIEDMAN PAUL A director director
Common Stock 8,840 $2.2 $19,448