Option
SCHRECK PATRICIA A officer: EVP, General Counsel officer: EVP, General Counsel
Common Stock 50,000 $6.15 $307,500 Sale
SCHRECK PATRICIA A officer: EVP, General Counsel officer: EVP, General Counsel
Common Stock 50,000 $20.67 $1,033,500 Option
SCHRECK PATRICIA A officer: EVP, General Counsel officer: EVP, General Counsel
Non-Qualified Stock Options 50,000 $6.15 $307,500 Sale
SCHRECK PATRICIA A officer: EVP, General Counsel officer: EVP, General Counsel
Common Stock 50,000 $6.15 $307,500 Option
SCHRECK PATRICIA A officer: EVP, General Counsel officer: EVP, General Counsel
Common Stock 50,000 $6.15 $307,500 Sale
WHITFIELD ROY A director director
Common Stock 10,000 $19.78 $197,800 Option
SCHRECK PATRICIA A officer: EVP, General Counsel officer: EVP, General Counsel
Incentive Stock Options 50,000 $6.15 $307,500 Sale
CHARDONNET LAURENT other: Vice President and Treasurer other: Vice President and Treas..
Common Stock 5,343 $19.55 $104,456 Sale
WHITFIELD ROY A director director
Common Stock 10,000 $19.31 $193,140 Option
METCALF BRIAN W officer: Chief Drug Discovery Scientist officer: Chief Drug Discovery S..
Common Stock 100,000 $5.46 $546,000 Sale
METCALF BRIAN W officer: Chief Drug Discovery Scientist officer: Chief Drug Discovery S..
Common Stock 100,000 $17.42 $1,742,000 Option
METCALF BRIAN W officer: Chief Drug Discovery Scientist officer: Chief Drug Discovery S..
Non Qualified Stock Option (right to buy) 82,688 $5.46 $451,476 Option
CHARDONNET LAURENT other: Vice President and Treasurer other: Vice President and Treas..
Incentive Stock Option (right to buy) 3,335 $3.11 $10,372 Sale
CHARDONNET LAURENT other: Vice President and Treasurer other: Vice President and Treas..
Common Stock 25,000 $17.04 $425,925 Option
CHARDONNET LAURENT other: Vice President and Treasurer other: Vice President and Treas..
Common Stock 25,000 $3.11 $77,750 Option
CHARDONNET LAURENT other: Vice President and Treasurer other: Vice President and Treas..
Non Qualified Stock Option (right to buy) 21,665 $3.11 $67,378 Option
SCHRECK PATRICIA A officer: EVP, General Counsel officer: EVP, General Counsel
Non Qualified Stock Option (right to buy) 100,000 $4.29 $428,500 Option
SCHRECK PATRICIA A officer: EVP, General Counsel officer: EVP, General Counsel
Common Stock 100,000 $4.29 $428,500 Sale
SCHRECK PATRICIA A officer: EVP, General Counsel officer: EVP, General Counsel
Common Stock 100,000 $16.5 $1,650,000 Sale
WHITFIELD ROY A director director
Common Stock 10,000 $16.03 $160,260 Option
ARIKO BARRY A director director
Non Qualified Stock Option (right to buy) 834 $14.13 $11,784 Option
ARIKO BARRY A director director
Common Stock 20,834 $14.13 $294,384 Sale
WHITFIELD ROY A director director
Common Stock 10,000 $14.71 $147,050 Option
METCALF BRIAN W officer: Chief Drug Discovery Scientist officer: Chief Drug Discovery S..
Common Stock 160,000 $10.59 $1,693,600 Sale
METCALF BRIAN W officer: Chief Drug Discovery Scientist officer: Chief Drug Discovery S..
Common Stock 159,800 $14.27 $2,279,867 Option
METCALF BRIAN W officer: Chief Drug Discovery Scientist officer: Chief Drug Discovery S..
Non-Qualified Stock Options 50,000 $14.25 $712,500 Sale
METCALF BRIAN W officer: Chief Drug Discovery Scientist officer: Chief Drug Discovery S..
Common Stock 50,000 $14.25 $712,500 Option
METCALF BRIAN W officer: Chief Drug Discovery Scientist officer: Chief Drug Discovery S..
Common Stock 50,000 $5.97 $298,500 Option
METCALF BRIAN W officer: Chief Drug Discovery Scientist officer: Chief Drug Discovery S..
Non-Qualified Stock Options 47,223 $5.97 $281,921 Purchase
DE SCHUTTER RICHARD U director, other: Chairman director, other: Chairman
4.75% Convertible Senior Notes due 2015 150,000 $8.78 $1,317,000 Option
FRIEDMAN PAUL A director director
Common Stock 20,000 $8.64 $172,800 Option
FRIEDMAN PAUL A director director
Incentive Stock Option (right to buy) 20,000 $8.64 $172,800 Option
METCALF BRIAN W officer: Chief Drug Discovery Scientist officer: Chief Drug Discovery S..
Common Stock 50,000 $5.97 $298,500 Option
METCALF BRIAN W officer: Chief Drug Discovery Scientist officer: Chief Drug Discovery S..
Non-Qualified Stock Options 50,000 $5.97 $298,500 Sale
METCALF BRIAN W officer: Chief Drug Discovery Scientist officer: Chief Drug Discovery S..
Common Stock 50,000 $5.97 $298,500 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
3.5% Senior Convertible Note due 2011 7,598,000 $11.22 $85,249,560 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 4,534,000 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 124,000 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Senior Convertible Note due 2011 206,000 $11.22 $2,311,320 Option
LEVY RICHARD S officer: EVP, Chief Drug Dev Officer officer: EVP, Chief Drug Dev Of..
Common Stock 40,310 $6.19 $249,519 Option
LEVY RICHARD S officer: EVP, Chief Drug Dev Officer officer: EVP, Chief Drug Dev Of..
Incentive Stock Options 15,000 $4.19 $62,850 Sale
LEVY RICHARD S officer: EVP, Chief Drug Dev Officer officer: EVP, Chief Drug Dev Of..
Common Stock 40,310 $15.83 $638,228 Sale
WHITFIELD ROY A director director
Common Stock 10,000 $17.14 $171,370 Sale
WHITFIELD ROY A director director
Common Stock 10,000 $17 $170,000 Sale
WHITFIELD ROY A director director
Common Stock 1,000 $15.9 $15,900 Sale
WHITFIELD ROY A director director
Common Stock 10,000 $16.01 $160,100 Sale
WHITFIELD ROY A director director
Common Stock 29,523 $16.99 $501,537 Sale
WHITFIELD ROY A director director
Common Stock 4,730 $16.95 $80,174 Sale
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 70,150 $14.86 $1,042,499 Sale
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 5,681 $14.86 $84,425 
