Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 144,486 $8.22 $1,188,108 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 387 $8.22 $3,182 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 318 $8.22 $2,615 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 46,836 $8.22 $385,132 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 4,566 $8.22 $37,546 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 33,157 $8.3 $275,303 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 225 $8.3 $1,868 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 274 $8.3 $2,275 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 102,285 $8.3 $849,272 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 3,232 $8.3 $26,835 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 108,405 $8.63 $934,993 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 290 $8.62 $2,501 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 382 $8.63 $3,295 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 42,843 $8.63 $369,521 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 3,426 $8.63 $29,549 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 446 $8.53 $3,806 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 50,099 $8.53 $427,545 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 126,766 $8.53 $1,081,821 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 4,006 $8.53 $34,187 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 340 $8.53 $2,902 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 145,054 $8.26 $1,197,856 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 389 $8.26 $3,212 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 511 $8.26 $4,220 Option
DE SCHUTTER RICHARD U director, other: Chairman director, other: Chairman
Common Stock 70,000 $4.25 $297,290 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 4,583 $8.26 $37,846 Option
DE SCHUTTER RICHARD U director, other: Chairman director, other: Chairman
Non-Qualified Stock Option (right to buy) 25,000 $4.44 $111,000 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 57,327 $8.26 $473,406 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 1,218 $8.18 $9,966 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 136,822 $8.18 $1,119,478 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 346,207 $8.18 $2,832,666 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 10,943 $8.18 $89,536 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 926 $8.18 $7,577 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 6,400 $7.8 $49,914 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 202,512 $7.8 $1,579,391 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 80,033 $7.8 $624,177 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 713 $7.8 $5,561 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 542 $7.8 $4,227 Purchase
FRIEDMAN PAUL A director director
Common Stock 16,665 $5.47 $91,174 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 64,003 $4.83 $308,878 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 430 $4.83 $2,075 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 5,366 $4.83 $25,896 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 168,797 $4.83 $814,614 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 46,012 $4.99 $229,738 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 1,463 $4.99 $7,305 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 17,446 $4.99 $87,108 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 117 $4.99 $584 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 237,052 $4.95 $1,172,459 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 604 $4.95 $2,987 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 89,883 $4.95 $444,561 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 7,536 $4.95 $37,273