Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5 % Subordinated Convertible Note due 2011 1,422,000 N/A N/A Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 1,851 $3.61 $6,675 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 89,241 $3.61 $321,803 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 1,927 $3.61 $6,949 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Senior Convertible Note due 2011 22,000 $5.61 $123,420 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 7,772 $3.61 $28,026 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Senior Convertible Note due 2011 412,000 $5.61 $2,311,320 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 248,000 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 9,068,000 N/A N/A Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Senior Convertible Note due 2011 1,000 $11.22 $11,219 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Senior Convertible Note due 2011 66,000 $11.22 $740,454 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 228,972 $3.58 $819,720 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Senior Convertible Note due 2011 18,000 $11.22 $201,942 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 6,252 $3.58 $22,382 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
3.5% Senior Convertible Note due 2011 2,436,000 $11.22 $27,329,484 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 68,463 $3.58 $245,098 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 1,628 $3.58 $5,828 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 133 $3.58 $476 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Senior Convertible Note due 2011 729,000 $11.22 $8,178,651 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 1,501 $3.27 $4,911 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 69,566 $3.27 $227,620 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 221,814 $3.27 $725,775 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 6,061 $3.27 $19,832 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 309 $3.27 $1,011 Purchase
METCALF BRIAN W officer: Chief Drug Discovery Scientist officer: Chief Drug Discovery S..
Common Stock 5,000 $2.19 $10,925 Purchase
SCHRECK PATRICIA A officer: EVP, General Counsel officer: EVP, General Counsel
Common Stock 2,500 $2.44 $6,100 Purchase
FRIEDMAN PAUL A director director
Common Stock 13,000 $2.55 $33,124 Purchase
CHARDONNET LAURENT other: Vice President and Treasurer other: Vice President and Treas..
Common Stock 8,000 $2.71 $21,640 Purchase
HASTINGS DAVID C officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 4,000 $2.36 $9,440 Purchase
FRIEDMAN PAUL A director director
Common Stock 5,300 $4.6 $24,380 Purchase
FRIEDMAN PAUL A director director
Common Stock 4,700 $5.35 $25,122 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 864,092 $9 $7,776,828 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 4,997 $9 $44,973 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 1,539 $9 $13,851 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 201,648 $9 $1,814,832 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 27,724 $9 $249,516 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Convertible Subordinated Notes due 2011 50,000 $5.61 $280,450 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Convertible Subordinated Notes due 2011 372,000 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Convertible Subordinated Notes due 2011 592,000 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
3.5% Convertible Subordinated Notes due 2011 18,612,000 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
3.5% Convertible Subordinated Notes due 2011 117,000 $11.22 $1,312,623 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Convertible Subordinated Notes due 2011 4,000 $11.22 $44,876 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Convertible Subordinated Notes due 2011 3,000 $11.22 $33,657 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 1 $10.62 $11 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 7 $10.62 $74 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 223 $10.62 $2,368 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 65 $10.62 $690 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 4 $10.62 $42 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 94 $10.99 $1,033 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 34,621 $10.99 $380,416