Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Senior Convertible Note due 2011 121,000 N/A N/A Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Senior Convertible Note due 2011 25,000 N/A N/A Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 20,000 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 3,493,000 N/A N/A Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 64 $2.16 $138 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 2,000 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 22,000 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5 % Subordinated Convertible Note due 2011 182,000 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 788,000 N/A N/A Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 8,000 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 66,000 $11.22 $740,454 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 264 $2.14 $565 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5 % Subordinated Convertible Note due 2011 546,000 $11.22 $6,125,574 Purchase
FRIEDMAN PAUL A director director
Common Stock 11,160 $2.2 $24,552 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 2,363,000 $11.22 $26,510,497 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 9,524 $2.14 $20,400 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 24,000 $11.22 $269,256 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 98 $2.14 $210 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 1,000 $11.22 $11,219 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 5 $2.16 $11 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 2,199 $2.14 $4,710 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 15,756,000 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5 % Subordinated Convertible Note due 2011 1,818,000 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 7,701 $2.15 $16,588 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 17 $2.15 $37 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 343 $2.15 $739 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 81,000 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 927 $2.15 $1,997 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 4,000 $11.22 $44,876 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 33,364 $2.15 $71,866 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 438,000 N/A N/A Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 3,000 N/A N/A Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 52,000 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 138,000 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5 % Subordinated Convertible Note due 2011 1,145,000 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 4,962,000 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 7,627,000 $11.22 $85,567,313 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 78,000 $11.22 $875,082 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5 % Subordinated Convertible Note due 2011 1,761,000 $11.22 $19,756,659 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 4,000 $11.22 $44,876 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 212,000 $11.22 $2,378,428 Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 12 $3.25 $39 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 85 $3.25 $276 Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 3 $3.25 $10 Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 62,000 N/A N/A Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Senior Convertible Note due 2011 104,000 $5.61 $583,440 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
3.5% Senior Convertible Note due 2011 15,196,000 $5.61 $85,249,560 Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 284,546 $3.61 $1,026,073 Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Subordinated Convertible Note due 2011 12,000 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
3.5% Senior Convertible Note due 2011 4,766,000 $5.61 $26,737,260