Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 18,832 N/A N/A Sale
CLINE DARREN S officer: EVP, Commercial officer: EVP, Commercial
Common Stock 2,860 N/A N/A Option
CLINE DARREN S officer: EVP, Commercial officer: EVP, Commercial
Non-Qualified Stock Option (right to buy) 8,268 N/A N/A Option
CLINE DARREN S officer: EVP, Commercial officer: EVP, Commercial
Common Stock 10,086 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 18,832 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Non-Qualified Stock Option (right to buy) 18,832 N/A N/A Sale
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 700 N/A N/A Option
HIMES VAUGHN B officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 5,000 N/A N/A Sale
HIMES VAUGHN B officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 5,000 N/A N/A Option
HIMES VAUGHN B officer: Chief Technical Officer officer: Chief Technical Officer
Non-Qualified Stock Option (right to buy) 5,000 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Non-Qualified Stock Option (right to buy) 18,832 N/A N/A Sale
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 4,316 N/A N/A Option
CLINE DARREN S officer: EVP, Commercial officer: EVP, Commercial
Non-Qualified Stock Option (right to buy) 9,000 N/A N/A Sale
CLINE DARREN S officer: EVP, Commercial officer: EVP, Commercial
Common Stock 9,000 N/A N/A Option
CLINE DARREN S officer: EVP, Commercial officer: EVP, Commercial
Common Stock 9,000 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 18,832 N/A N/A Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 126,399 N/A N/A Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 129,715 N/A N/A Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 204,537 N/A N/A Sale
CLINE DARREN S officer: EVP, Commercial officer: EVP, Commercial
Common Stock 4,000 N/A N/A Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 69,947 N/A N/A Option
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 20,000 N/A N/A Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 306,917 N/A N/A Option
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Non-Qualified Stock Options (right to buy) 10,000 N/A N/A Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 623,136 N/A N/A Sale
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 18,832 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Non-Qualified Stock Option (right to buy) 18,832 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 18,832 N/A N/A Option
DRACHMAN JONATHAN G officer: See Remarks officer: See Remarks
Non-Qualified Stock Option (right to buy) 13,740 N/A N/A Option
DRACHMAN JONATHAN G officer: See Remarks officer: See Remarks
Common Stock 31,039 N/A N/A Option
DRACHMAN JONATHAN G officer: See Remarks officer: See Remarks
Incentive Stock Option (right to buy) 6,468 N/A N/A Sale
HIMES VAUGHN B officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 5,000 N/A N/A Option
HIMES VAUGHN B officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 5,000 N/A N/A Option
HIMES VAUGHN B officer: Chief Technical Officer officer: Chief Technical Officer
Non-Qualified Stock Option (right to buy) 5,000 N/A N/A Sale
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 4,764 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Non-Qualified Stock Option (right to buy) 18,832 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 18,832 N/A N/A Option
DRACHMAN JONATHAN G officer: See Remarks officer: See Remarks
Common Stock 10,457 N/A N/A Sale
DRACHMAN JONATHAN G officer: See Remarks officer: See Remarks
Common Stock 7,200 N/A N/A Option
DRACHMAN JONATHAN G officer: See Remarks officer: See Remarks
Non-Qualified Stock Option (right to buy) 10,457 N/A N/A Option
WELCH DANIEL G director director
Common Stock 16,881 N/A N/A Option
WELCH DANIEL G director director
Non-Qualified Stock Option (right to buy) 6,881 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 18,832 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Non-Qualified Stock Option (right to buy) 18,832 N/A N/A Sale
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 800 N/A N/A Purchase
BAKER BROS. ADVISORS LP director, 10 percent owner director, 10 percent owner
Common Stock 3,846,153 N/A N/A Option
DRACHMAN JONATHAN G officer: See Remarks officer: See Remarks
Non-Qualified Stock Option (right to buy) 13,156 N/A N/A Option
DRACHMAN JONATHAN G officer: See Remarks officer: See Remarks
Incentive Stock Option (right to buy) 6,260 N/A N/A Sale
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 10,570 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Non-Qualified Stock Option (right to buy) 18,832 N/A N/A